TYRO protein tyrosine kinase binding protein (Q21992241)

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mammalian protein found in Mus musculus

KAR-associated protein
killer-activating receptor-associated protein
Tyrobp
DNAX-activation protein 12
TYRO protein tyrosine kinase-binding protein
killer cell activating receptor associated protein

Language	Label	Description	Also known as
English	TYRO protein tyrosine kinase binding protein	mammalian protein found in Mus musculus	KAR-associated protein killer-activating receptor-associated protein Tyrobp DNAX-activation protein 12 TYRO protein tyrosine kinase-binding protein killer cell activating receptor associated protein

Statements

1 reference

25 May 2022

UniProt protein ID

TYRO protein tyrosine kinase-binding protein

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O54885

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

protein binding

determination method

10 references

8 April 2019

Characterization of TREM-3, an activating receptor on mouse macrophages: definition of a family of single Ig domain receptors on mouse chromosome 17

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

8 April 2019

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

8 April 2019

Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

8 April 2019

Rhomboid domain-containing protein 3 is a negative regulator of TLR3-triggered natural killer cell activation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

8 April 2019

Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

8 April 2019

Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

8 April 2019

A new triggering receptor expressed on myeloid cells (Trem) family member, Trem-like 4, binds to dead cells and is a DNAX activation protein 12-linked marker for subsets of mouse macrophages and dendritic cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

8 April 2019

Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

8 April 2019

Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

8 April 2019

Signal adaptor DAP10 associates with MDL-1 and triggers osteoclastogenesis in cooperation with DAP12

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

signaling receptor binding

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

determination method

plasma membrane

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

8 April 2019

Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

plasma membrane

determination method

2 references

biological process

integrin-mediated signaling pathway

determination method

1 reference

8 April 2019

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

macrophage activation involved in immune response

determination method

1 reference

8 April 2019

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

regulation of osteoclast development

determination method

1 reference

8 April 2019

Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

neutrophil activation involved in immune response

determination method

1 reference

8 April 2019

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

osteoclast differentiation

determination method

5 references

8 April 2019

OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

8 April 2019

OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

8 April 2019

OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

8 April 2019

OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

myeloid leukocyte activation

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54885&geneProductId=UniProtKB:O54885

determination method

positive regulation of natural killer cell activation

determination method

1 reference

8 April 2019

Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

positive regulation of microglial cell mediated cytotoxicity

determination method

1 reference

8 April 2019

Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

positive regulation of protein localization to cell surface

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54885&geneProductId=UniProtKB:O54885

determination method

positive regulation of osteoclast development

determination method

1 reference

8 April 2019

The signaling adapter protein DAP12 regulates multinucleation during osteoclast development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

microglial cell activation involved in immune response

determination method

positive regulation of gene expression

determination method

1 reference

8 April 2019

A DAP12-dependent signal promotes pro-inflammatory polarization in microglia following nerve injury and exacerbates degeneration of injured neurons.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

actin cytoskeleton organization

determination method

1 reference

8 April 2019

DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

forebrain development

determination method

1 reference

8 April 2019

Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

negative regulation of transforming growth factor beta1 production

determination method

1 reference

8 April 2019

A DAP12-dependent signal promotes pro-inflammatory polarization in microglia following nerve injury and exacerbates degeneration of injured neurons.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

positive regulation of superoxide anion generation

determination method

1 reference

8 April 2019

Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

positive regulation of macrophage fusion

determination method

3 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

8 April 2019

Essential role of DAP12 signaling in macrophage programming into a fusion-competent state

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

response to axon injury

determination method

1 reference

8 April 2019

A DAP12-dependent signal promotes pro-inflammatory polarization in microglia following nerve injury and exacerbates degeneration of injured neurons.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

protein stabilization

determination method

apoptotic signaling pathway

determination method

1 reference

8 April 2019

Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

positive regulation of hippocampal neuron apoptotic process

determination method

1 reference

8 April 2019

Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

negative regulation of long-term synaptic potentiation

determination method

1 reference

8 April 2019

Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

positive regulation of neuron death

determination method

1 reference

8 April 2019

A DAP12-dependent signal promotes pro-inflammatory polarization in microglia following nerve injury and exacerbates degeneration of injured neurons.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

positive regulation of receptor localization to synapse

determination method

1 reference

8 April 2019

Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

negative regulation of B cell proliferation

determination method

3 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

8 April 2019

The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

apoptotic cell clearance

determination method

1 reference

8 April 2019

Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

immune system process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000032800

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000032800

ENSMUSP00000146494

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000146494

ENSMUSP00000146653

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000146653

Sitelinks

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Wikisource(0 entries)

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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