TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. (Q51764852)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29518356%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

title

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function (English)

1 reference

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19 March 2020

1 reference

protein tyrosine kinase binding

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TYRO protein tyrosine kinase binding protein

GOA release 2020-03-11

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Triggering receptor expressed on myeloid cells 2

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Juan C Piña-Crespo

9

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19 March 2020

author name string

Yingjun Zhao

1

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19 March 2020

Xilin Wu

2

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19 March 2020

Xiaoguang Li

3

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19 March 2020

Lu-Lin Jiang

4

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19 March 2020

Xun Gui

5

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19 March 2020

Yan Liu

6

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19 March 2020

Yu Sun

7

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19 March 2020

Bing Zhu

8

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19 March 2020

Muxian Zhang

10

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19 March 2020

Ningyan Zhang

11

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19 March 2020

Xiaochun Chen

12

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19 March 2020

Guojun Bu

13

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19 March 2020

Zhiqiang An

14

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19 March 2020

Timothy Y Huang

15

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19 March 2020

Huaxi Xu

16

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19 March 2020

language of work or name

English

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publication date

1 March 2018

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19 March 2020

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19 March 2020

volume

97

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19 March 2020

issue

5

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19 March 2020

page(s)

1023-1031.e7

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ER-associated degradation regulates Alzheimer's amyloid pathology and memory function by modulating γ-secretase activity

19 March 2020

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TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease

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TREM2 in Neurodegenerative Diseases

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TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.

7 September 2018

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Soluble TREM2 induces inflammatory responses and enhances microglial survival.

7 September 2018

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Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease.

7 September 2018

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Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

7 September 2018

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Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

7 September 2018

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Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer's disease brains

7 September 2018

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TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.

7 September 2018

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SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein.

7 September 2018

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TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

7 September 2018

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7 September 2018

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Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).

7 September 2018

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Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis

7 September 2018

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Expression and contributions of the Kir2.1 inward-rectifier K(+) channel to proliferation, migration and chemotaxis of microglia in unstimulated and anti-inflammatory states

7 September 2018

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DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response

7 September 2018

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TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.

7 September 2018

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TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model

7 September 2018

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7 September 2018

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TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

7 September 2018

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Coding variants in TREM2 increase risk for Alzheimer's disease

7 September 2018

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7 September 2018

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7 September 2018

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7 September 2018

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7 September 2018

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7 September 2018

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7 September 2018

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7 September 2018

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7 September 2018

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7 September 2018

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7 September 2018

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7 September 2018

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7 September 2018

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7 September 2018

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Identification of Gas6 as a ligand for Mer, a neural cell adhesion molecule related receptor tyrosine kinase implicated in cellular transformation.

7 September 2018

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10.1016/J.NEURON.2018.01.031

7 September 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29518356%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29518356%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

PubMed publication ID

29518356

1 reference