WW domain containing E3 ubiquitin protein ligase 1 (Q21992737)

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mammalian protein found in Mus musculus

WW domain-containing protein 1
NEDD4-like E3 ubiquitin-protein ligase WWP1
HECT-type E3 ubiquitin transferase WWP1
Wwp1

Language	Label	Description	Also known as
English	WW domain containing E3 ubiquitin protein ligase 1	mammalian protein found in Mus musculus	WW domain-containing protein 1 NEDD4-like E3 ubiquitin-protein ligase WWP1 HECT-type E3 ubiquitin transferase WWP1 Wwp1

Statements

1 reference

25 May 2022

UniProt protein ID

HECT, E3 ligase catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8BZZ3

WW domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8BZZ3

C2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8BZZ3

E3 ubiquitin-protein ligase, SMURF1 type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8BZZ3

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

HECT domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

C2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

WW domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

ubiquitin-protein transferase activity

determination method

3 references

14 February 2019

A HECT domain ubiquitin ligase closely related to the mammalian protein WWP1 is essential for Caenorhabditis elegans embryogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BZZ3

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BZZ3

determination method

14 February 2019

WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BZZ3

determination method

protein binding

determination method

2 references

transferase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BZZ3

determination method

ubiquitin protein ligase activity

determination method

3 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BZZ3&geneProductId=UniProtKB:Q8BZZ3

determination method

27 February 2018

WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BZZ3&geneProductId=UniProtKB:Q8BZZ3

determination method

27 February 2018

Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BZZ3&geneProductId=UniProtKB:Q8BZZ3

determination method

ubiquitin protein ligase activity

determination method

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BZZ3

determination method

14 February 2019

WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BZZ3

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BZZ3

determination method

14 February 2019

Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BZZ3

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BZZ3

determination method

plasma membrane

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BZZ3

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BZZ3

determination method

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BZZ3

determination method

biological process

lung development

determination method

1 reference

14 February 2019

Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BZZ3

determination method

T cell differentiation

determination method

1 reference

14 February 2019

Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BZZ3

determination method

protein ubiquitination

determination method

3 references

27 February 2018

A HECT domain ubiquitin ligase closely related to the mammalian protein WWP1 is essential for Caenorhabditis elegans embryogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BZZ3&geneProductId=UniProtKB:Q8BZZ3

determination method

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BZZ3&geneProductId=UniProtKB:Q8BZZ3

determination method

27 February 2018

WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BZZ3&geneProductId=UniProtKB:Q8BZZ3

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

14 February 2019

Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BZZ3

determination method

proteasome-mediated ubiquitin-dependent protein catabolic process

determination method

2 references

ubiquitin-dependent protein catabolic process

determination method

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BZZ3&geneProductId=UniProtKB:Q8BZZ3

determination method

protein polyubiquitination

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BZZ3

determination method

protein ubiquitination

determination method

4 references

14 February 2019

A HECT domain ubiquitin ligase closely related to the mammalian protein WWP1 is essential for Caenorhabditis elegans embryogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BZZ3

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BZZ3

determination method

14 February 2019

WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BZZ3

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BZZ3

determination method

proteasome-mediated ubiquitin-dependent protein catabolic process

determination method

3 references

14 February 2019

WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BZZ3

determination method

14 February 2019

The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BZZ3

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BZZ3

determination method

positive regulation of protein catabolic process

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BZZ3

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8BZZ3

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8BZZ3

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8BZZ3

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000041627

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000041627

ENSMUSP00000103881

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000103881

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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