Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein (Q22010970)

GOA release 2020-03-11

MDM2 proto-oncogene

1 reference

protein-containing complex assembly

GOA release 2020-03-11

1 reference

Journal of Biological Chemistry

GOA release 2020-03-11

D A Sharp

1

D A

Sharp

1 reference

7 February 2023

S A Kratowicz

series ordinal

2

author given names

S A

author last names

Kratowicz

1 reference

7 February 2023

M J Sank

series ordinal

3

author given names

M J

author last names

Sank

1 reference

7 February 2023

D L George

series ordinal

4

author given names

D L

author last names

George

1 reference

7 February 2023

language of work or name

English

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publication date

31 December 1999

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published in

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volume

274

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page(s)

38189-96

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issue

53

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cites work

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Mdm2: keeping p53 under control

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

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Mdm2 promotes the rapid degradation of p53

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A novel MDMX transcript expressed in a variety of transformed cell lines encodes a truncated protein with potent p53 repressive activity

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The p53-associated protein MDM2 contains a newly characterized zinc-binding domain called the RING finger

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Metal and RNA binding properties of the hdm2 RING finger domain

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