What fraction of the human genome is functional? (Q22065769)

A user's guide to the encyclopedia of DNA elements (ENCODE)

Europe PubMed Central

title

What fraction of the human genome is functional? (English)

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1

Chris P Ponting

Chris P

Ponting

1 reference

7 February 2023

Ross C Hardison

2

Ross C

Hardison

1 reference

7 February 2023

language of work or name

English

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publication date

November 2011

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published in

Genome Research

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volume

21

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page(s)

1769-76

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issue

11

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cites work

1 reference

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19 March 2017

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Massive turnover of functional sequence in human and other mammalian genomes

19 March 2017

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19 March 2017

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Thousands of human mobile element fragments undergo strong purifying selection near developmental genes

19 March 2017

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19 March 2017

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7 April 2017

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7 April 2017

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7 April 2017

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Rapid turnover of functional sequence in human and other genomes

28 May 2017

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12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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Identification and characterization of multi-species conserved sequences

12 September 2017

1 reference

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12 September 2017

1 reference

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Evolution of transcription factor binding sites in Mammalian gene regulatory regions: conservation and turnover

12 September 2017

1 reference

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Detecting conserved regulatory elements with the model genome of the Japanese puffer fish, Fugu rubripes

12 September 2017

1 reference

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Experimental validation of predicted mammalian erythroid cis-regulatory modules

12 September 2017

1 reference

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An enhancer element lies 3' to the human A gamma globin gene

27 September 2017

1 reference

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Evolution of the mammalian transcription factor binding repertoire via transposable elements

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205562

Tissue-specific transcriptional regulation has diverged significantly between human and mouse

30 May 2018

1 reference

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A lymphocyte-specific enhancer in the mouse immunoglobulin kappa gene.

30 May 2018

1 reference

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Transposable elements have rewired the core regulatory network of human embryonic stem cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205562

Distributions of selectively constrained sites and deleterious mutation rates in the hominid and murid genomes.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205562

Uncertainty in homology inferences: assessing and improving genomic sequence alignment

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205562

Megabase deletions of gene deserts result in viable mice

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205562

The share of human genomic DNA under selection estimated from human-mouse genomic alignments.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205562

Differences in the chromatin structure and cis-element organization of the human and mouse GATA1 loci: implications for cis-element identification

29 November 2018

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Significance of interspecies matches when evolutionary rate varies.

29 November 2018

1 reference

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Comparative genome analysis delimits a chromosomal domain and identifies key regulatory elements in the alpha globin cluster

29 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/21875934

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A high-resolution map of human evolutionary constraint using 29 mammals

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15 July 2023

Identifiers

DOI

10.1101/GR.116814.110

1 reference

2747173

2747173

1 reference

1 reference

1 reference