The genetic contribution to non-syndromic human obesity (Q22251027)

Europe PubMed Central

title

The genetic contribution to non-syndromic human obesity (English)

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3

Philippe Froguel

Philippe

Froguel

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Dimensions

7 February 2023

Andrew J. Walley

1

Andrew J.

Walley

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Dimensions

1037012536

7 February 2023

Julian E. Asher

series ordinal

2

author given names

Julian E.

author last names

Asher

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Dimensions

1037012536

Will all Americans become overweight or obese? estimating the progression and cost of the US obesity epidemic

7 February 2023

language of work or name

English

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publication date

July 2009

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published in

Nature Reviews Genetics

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volume

10

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page(s)

431-442

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issue

7

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cites work

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Individual estimates of European genetic admixture associated with lower body-mass index, plasma glucose, and prevalence of type 2 diabetes in Pima Indians

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Fasting and leptin modulate adipose and muscle uncoupling protein: divergent effects between messenger ribonucleic acid and protein expression.

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Hypothalamic arcuate nucleus mediates the sympathetic and arterial pressure responses to leptin.

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Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of diet-induced obesity in rats treated with a beta3-adrenoceptor agonist

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Unexpected evidence for active brown adipose tissue in adult humans

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Profiling Postprandial Thermogenesis in Muscle and Fat of Sheep and the Central Effect of Leptin Administration

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A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

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A frameshift mutation in human MC4R is associated with a dominant form of obesity

31 March 2020

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A frameshift mutation in MC4R associated with dominantly inherited human obesity

31 March 2020

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Profound obesity associated with a balanced translocation that disrupts the SIM1 gene

31 March 2020

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Mutation screen of the brain derived neurotrophic factor gene (BDNF): Identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder

31 March 2020

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A de novo mutation affecting human TrkB associated with severe obesity and developmental delay

31 March 2020

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The human obesity gene map: the 2005 update

31 March 2020

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GAD2 on chromosome 10p12 is a candidate gene for human obesity

31 March 2020

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Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes

31 March 2020

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The SLC6A14 gene shows evidence of association with obesity

31 March 2020

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Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians

31 March 2020

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Meta-Analysis of Genome-wide Linkage Studies in BMI and Obesity*

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A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

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Common variants in the 5' region of the leptin gene are associated with body mass index in men from the National Heart, Lung, and Blood Institute Family Heart Study.

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Sequence variants in the 5' flanking region of the leptin gene are associated with obesity in women

31 March 2020

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Transmission disequilibrium and sequence variants at the leptin receptor gene in extremely obese German children and adolescents

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Leptin gene and leptin receptor gene polymorphisms are associated with sweet preference and obesity

31 March 2020

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A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism

31 March 2020

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Common nonsynonymous variants in PCSK1 confer risk of obesity

31 March 2020

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Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants

31 March 2020

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Mutational analysis of melanocortin-4 receptor, agouti-related protein, and α-melanocyte-stimulating hormone genes in severely obese children

31 March 2020

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Melanocortin-4 receptor gene variant I103 is negatively associated with obesity

31 March 2020

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Association of the 103I MC4R allele with decreased body mass in 7937 participants of two population based surveys

31 March 2020

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Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene

31 March 2020

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ACDC/Adiponectin Polymorphisms Are Associated With Severe Childhood and Adult Obesity

31 March 2020

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Genetic analysis of adiponectin and obesity in Hispanic families: the IRAS Family Study.

31 March 2020

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A novel association of a polymorphism in the first intron of adiponectin gene with type 2 diabetes, obesity and hypoadiponectinemia in Asian Indians

31 March 2020

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Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations

31 March 2020

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Modulation of blood pressure and obesity with the dopamine D2 receptor gene TaqI polymorphism.

31 March 2020

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Food reinforcement, the dopamine D2 receptor genotype, and energy intake in obese and nonobese humans

31 March 2020

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Complex HTR2C linkage disequilibrium and promoter associations with body mass index and serum leptin.

31 March 2020

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A 5-HT2C receptor promoter polymorphism (HTR2C - 759C/T) is associated with obesity in women, and with resistance to weight loss in heterozygotes

31 March 2020

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Genes implicated in serotonergic and dopaminergic functioning predict BMI categories

31 March 2020

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A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference

31 March 2020

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The International HapMap Project

31 March 2020

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A haplotype map of the human genome

31 March 2020

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A second generation human haplotype map of over 3.1 million SNPs

31 March 2020

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Genome-wide association studies for complex traits: consensus, uncertainty and challenges

31 March 2020

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The genetic basis of complex traits: rare variants or "common gene, common disease"?

31 March 2020

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Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

31 March 2020

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Variation in FTO contributes to childhood obesity and severe adult obesity

31 March 2020

1 reference

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

31 March 2020

1 reference

FTO: the first gene contributing to common forms of human obesity

31 March 2020

1 reference

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase

31 March 2020

1 reference

Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure

31 March 2020

1 reference

The FTO gene and measured food intake in children

31 March 2020

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Obesity associated genetic variation in FTO is associated with diminished satiety

31 March 2020

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The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis

31 March 2020

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Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation

31 March 2020

1 reference

Common variants near MC4R are associated with fat mass, weight and risk of obesity

31 March 2020

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Common genetic variation near MC4R is associated with waist circumference and insulin resistance

31 March 2020

1 reference

Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes

31 March 2020

1 reference

The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women

31 March 2020

1 reference

A common genetic variant is associated with adult and childhood obesity

31 March 2020

1 reference

Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"

31 March 2020

1 reference

Comment on "A common genetic variant is associated with adult and childhood obesity"

31 March 2020

1 reference

Comment on "A common genetic variant is associated with adult and childhood obesity"

31 March 2020

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The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts

31 March 2020

1 reference

Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits

31 March 2020

1 reference

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

31 March 2020

1 reference

Large-scale analysis of the human and mouse transcriptomes

31 March 2020

1 reference

Relevance of Niemann-Pick type C1 protein expression in controlling plasma cholesterol and biliary lipid secretion in mice

31 March 2020

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Cellular cholesterol trafficking and compartmentalization

31 March 2020

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Lipid imbalance in the neurological disorder, Niemann-Pick C disease

31 March 2020

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Genome-wide association scans identified CTNNBL1 as a novel gene for obesity.

31 March 2020

1 reference

TCF7L2 genetic defect and type 2 diabetes

31 March 2020

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Inhibition of adipogenesis by Wnt signaling

31 March 2020

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Wnt-beta-catenin signaling initiates taste papilla development

31 March 2020

1 reference

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

31 March 2020

1 reference

The power of the extreme in elucidating obesity.

31 March 2020

1 reference

On the replication of genetic associations: timing can be everything!

31 March 2020

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Mapping complex disease traits with global gene expression

31 March 2020

1 reference

Transcriptomic and metabonomic profiling of obesity-prone and obesity-resistant rats under high fat diet.

31 March 2020

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Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals

31 March 2020

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Designing candidate gene and genome-wide case-control association studies.

31 March 2020

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An overview of the genetic dissection of complex traits

31 March 2020

1 reference

Common statistical issues in genome-wide association studies: a review on power, data quality control, genotype calling and population structure

31 March 2020

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What can genome-wide association studies tell us about the genetics of common disease?

31 March 2020

1 reference

Family study designs in the age of genome-wide association studies: experience from the Framingham Heart Study

31 March 2020

1 reference

Genes, environment and the value of prospective cohort studies

31 March 2020

1 reference

Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae

31 March 2020

1 reference

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis

31 March 2020

1 reference

Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes

31 March 2020

1 reference

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

31 March 2020

1 reference

Relative impact of nucleotide and copy number variation on gene expression phenotypes

31 March 2020

1 reference

Array CGH analysis of copy number variation identifies 1284 new genes variant in healthy white males: implications for association studies of complex diseases

31 March 2020

1 reference

Structural variation in the human genome

31 March 2020

1 reference

High-resolution genomic profiling of chromosomal aberrations using Infinium whole-genome genotyping

31 March 2020

1 reference

Integrated detection and population-genetic analysis of SNPs and copy number variation

31 March 2020

1 reference

Assessment of algorithms for high throughput detection of genomic copy number variation in oligonucleotide microarray data

31 March 2020

1 reference

Mechanisms of imprinting of the Prader-Willi/Angelman region.

31 March 2020

1 reference

Possible genomic imprinting of three human obesity-related genetic loci

31 March 2020

1 reference

Assessment of genetic linkage and parent-of-origin effects on obesity.

31 March 2020

1 reference

The thrifty epigenotype: an acquired and heritable predisposition for obesity and diabetes?

31 March 2020

1 reference

High-throughput DNA methylation profiling using universal bead arrays

31 March 2020

1 reference

Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells

31 March 2020

1 reference

Evaluation and integration of 49 genome-wide experiments and the prediction of previously unknown obesity-related genes

31 March 2020

1 reference

A comparison of direct vs. self-report measures for assessing height, weight and body mass index: a systematic review

31 March 2020

1 reference

Whole-body three-dimensional photonic scanning: a new technique for obesity research and clinical practice.

31 March 2020

1 reference

Body-composition assessment in infancy: air-displacement plethysmography compared with a reference 4-compartment model

31 March 2020

1 reference

Application of imaging and other noninvasive techniques in determining adipose tissue mass

31 March 2020

1 reference

Sonographic assessment of regional adiposity.

31 March 2020

1 reference

Validity of the assessment of dietary intake: problems of misreporting

31 March 2020

1 reference

Digital photography as a tool to measure school cafeteria consumption

31 March 2020

1 reference

Performance of a method for identifying the unique dietary patterns of adult women and men: the Framingham nutrition studies

31 March 2020

1 reference

Breakfast skipping and body mass index among adolescents in Greece: whether an association exists depends on how breakfast skipping is defined

31 March 2020

1 reference

Central nervous system control of food intake and body weight

31 March 2020

1 reference

Adipose tissue hormones and the regulation of food intake

31 March 2020

1 reference

Adipocytes as regulators of energy balance and glucose homeostasis

31 March 2020

1 reference

Obesity and the regulation of energy balance

31 March 2020

1 reference

Common variation in LMNA increases susceptibility to type 2 diabetes and associates with elevated fasting glycemia and estimates of body fat and height in the general population: studies of 7,495 Danish whites.

31 March 2020

1 reference

Genetic linkage and association of the growth hormone secretagogue receptor (ghrelin receptor) gene in human obesity

31 March 2020

1 reference

Functional SOCS1 polymorphisms are associated with variation in obesity in whites.

31 March 2020

1 reference

Polymorphisms near SOCS3 are associated with obesity and glucose homeostasis traits in Hispanic Americans from the Insulin Resistance Atherosclerosis Family Study

31 March 2020

1 reference

Variation in the gene encoding Krüppel-like factor 7 influences body fat: studies of 14 818 Danes

31 March 2020

1 reference

Association of single-nucleotide polymorphisms in MTMR9 gene with obesity.

31 March 2020

1 reference

Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans.

31 March 2020

1 reference

TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition

31 March 2020

1 reference

Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects

31 March 2020

1 reference

Childhood overweight and family income.

31 March 2020

1 reference

12 December 2020

Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin,

1 reference

12 December 2020

A Rare Variant in the Visfatin Gene (NAMPT/PBEF1) Is Associated With Protection From Obesity

1 reference

12 December 2020

Adiponectin gene variation associates with the increasing risk of type 2 diabetes in non-diabetic Japanese subjects

1 reference

12 December 2020

Cholesterol balance and metabolism in mice with loss of function of Niemann-Pick C protein.

1 reference

12 December 2020

Associations between the leptin receptor gene and adiposity in middle-aged Caucasian males from the HERITAGE family study

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRG2594

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Consolidated OpenCitations Corpus – April 2017

2301489

release_x4v5h3d2wrc45njuz5rvtt352i

1037012536

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Fatcat ID

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2301489

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference