Mechanisms of Disease: pathogenesis of Crohn's disease and ulcerative colitis (Q22251072)

Dimensions Publication ID

Dimensions

1007971314

Nature Reviews Gastroenterology & Hepatology

7 February 2023

language of work or name

English

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publication date

July 2006

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published in

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volume

3

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page(s)

390-407

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issue

7

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cites work

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

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A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

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Bacterial interactions with cells of the intestinal mucosa: Toll-like receptors and NOD2

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CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells

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GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells

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Crohn's disease and the NOD2 gene: a role for paneth cells

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Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract

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Reduced Paneth cell alpha-defensins in ileal Crohn's disease

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NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

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Mucosal flora in inflammatory bowel disease

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Functional variants of OCTN cation transporter genes are associated with Crohn disease

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The Contribution of OCTN1/2 Variants Within the IBD5 Locus to Disease Susceptibility and Severity in Crohn’s Disease

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Genetic variation in DLG5 is associated with inflammatory bowel disease

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Allelic variations of the multidrug resistance gene determine susceptibility and disease behavior in ulcerative colitis

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MDR1 Ala893 polymorphism is associated with inflammatory bowel disease

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High multidrug resistance (P-glycoprotein 170) expression in inflammatory bowel disease patients who fail medical therapy

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Linkage to peroxisome proliferator-activated receptor-gamma in SAMP1/YitFc mice and in human Crohn's disease

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Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis.

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Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma

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A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response

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Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)

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Association of antibody responses to microbial antigens and complications of small bowel Crohn's disease.

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A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group.

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Anti-interleukin-12 antibody for active Crohn's disease

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Leukocytapheresis in ulcerative colitis: results of a multicenter double-blind prospective case-control study with sham apheresis as placebo treatment.

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7 January 2021

Cyclosporine in severe ulcerative colitis refractory to steroid therapy

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7 January 2021

Neutrophil transepithelial migration: role of toll-like receptors in mucosal inflammation

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Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity

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Toll-like receptor control of the adaptive immune responses

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Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: a randomized, placebo-controlled study.

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Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice

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7 January 2021

IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium

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The two faces of IKK and NF-κB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion

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MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis

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7 January 2021

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis

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7 January 2021

Distinct inflammatory mechanisms mediate early versus late colitis in mice

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7 January 2021

Proinflammatory effects of TH2 cytokines in a murine model of chronic small intestinal inflammation

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7 January 2021

Interleukin-17 family members and inflammation

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7 January 2021

Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells

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7 January 2021

Increased expression of interleukin 17 in inflammatory bowel disease

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7 January 2021

Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis

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7 January 2021

IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6

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7 January 2021

Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease

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7 January 2021

The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease

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Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis.

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7 January 2021

Characteristics of Intestinal Dendritic Cells in Inflammatory Bowel Diseases

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Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitis

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7 January 2021

Chemokine receptors and leukocyte trafficking in the mucosal immune system.

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Demonstration of functional role of TECK/CCL25 in T lymphocyte-endothelium interaction in inflamed and uninflamed intestinal mucosa

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7 January 2021

CCR2 expressing CD4+ T lymphocytes are preferentially recruited to the ileum in Crohn's disease.

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7 January 2021

Natalizumab for active Crohn's disease

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7 January 2021

Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin

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7 January 2021

IKK beta and phosphatidylinositol 3-kinase/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NF-kappa B activation in both primary and intestinal epithelial cell lines

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7 January 2021

IL-10 gene-deficient mice lack TGF-beta/Smad signaling and fail to inhibit proinflammatory gene expression in intestinal epithelial cells after the colonization with colitogenic Enterococcus faecalis.

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7 January 2021

Bacterial flagellin is a dominant antigen in Crohn disease.

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7 January 2021

Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease.

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7 January 2021

STAT3 regulates NF-kappaB recruitment to the IL-12p40 promoter in dendritic cells.

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7 January 2021

Toll-like receptor 9-induced type I IFN protects mice from experimental colitis

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7 January 2021

Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria.

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7 January 2021

Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice

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7 January 2021

Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria

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7 January 2021

Antineutrophil cytoplasmic antibodies in T-cell receptor alpha-deficient mice with chronic colitis

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7 January 2021

Suppressive role of B cells in chronic colitis of T cell receptor alpha mutant mice

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7 January 2021

Surveillance B lymphocytes and mucosal immunoregulation

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7 January 2021

Bacterial-reactive T regulatory cells inhibit pathogenic immune responses to the enteric flora

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7 January 2021

Continuous stimulation by normal luminal bacteria is essential for the development and perpetuation of colitis in Tg(epsilon26) mice

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7 January 2021

Analysis of the large bowel microbiota of colitic mice using PCR/DGGE.

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7 January 2021

The COX-2 story: is any drug completely "safe?".

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7 January 2021

Lactobacillus GG prevents recurrence of colitis in HLA-B27 transgenic rats after antibiotic treatment

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7 January 2021

Lactobacillus plantarum 299V in the treatment and prevention of spontaneous colitis in interleukin-10-deficient mice

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7 January 2021

Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics

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VSL#3 Probiotic-Mixture Induces Remission in Patients with Active Ulcerative Colitis

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7 January 2021

Effect of Lactobacillus rhamnosus GG on ileal pouch inflammation and microbial flora

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Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial

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Rapid development of colitis in NSAID-treated IL-10-deficient mice.

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7 January 2021

Bacterial-metal interactions: the potential role of aluminum and other trace elements in the etiology of Crohn's disease

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7 January 2021

Inflammatory bowel disease and smoking: a review of epidemiology, pathophysiology, and therapeutic implications

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7 January 2021

Tobacco and IBD: relevance in the understanding of disease mechanisms and clinical practice

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7 January 2021

Does Mycobacterium avium subspecies paratuberculosis cause Crohn's disease?

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https://api.crossref.org/works/10.1038%2FNCPGASTHEP0528

7 January 2021

Possible role of mycobacteria in inflammatory bowel disease. I. An unclassified Mycobacterium species isolated from patients with Crohn's disease

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https://api.crossref.org/works/10.1038%2FNCPGASTHEP0528

7 January 2021

Open clinical trial of rifabutin and clarithromycin therapy in Crohn's disease

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7 January 2021

IS900 PCR to detect Mycobacterium paratuberculosis in retail supplies of whole pasteurized cows' milk in England and Wales.

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https://api.crossref.org/works/10.1038%2FNCPGASTHEP0528

7 January 2021

Isolation of Mycobacterium avium subsp paratuberculosis from breast milk of Crohn's disease patients

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https://api.crossref.org/works/10.1038%2FNCPGASTHEP0528

7 January 2021

Culture of Mycobacterium avium subspecies paratuberculosis from the blood of patients with Crohn's disease.

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https://api.crossref.org/works/10.1038%2FNCPGASTHEP0528

7 January 2021

High prevalence of Mycobacterium avium subspecies paratuberculosis IS900 DNA in gut tissues from individuals with Crohn's disease

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7 January 2021

Effect of a test and control program for bovine Johne's disease in Victorian dairy herds 1992 - 2002.

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7 January 2021

The distribution of Mycobacterium avium ssp. paratuberculosis in the environment surrounding Minnesota dairy farms

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7 January 2021

Pasteurization of milk and the heat resistance of Mycobacterium avium subsp. paratuberculosis: a critical review of the data

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7 January 2021

High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn’s disease

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7 January 2021

Immunocytochemical evidence of Listeria, Escherichia coli, and Streptococcus antigens in Crohn's disease

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7 January 2021

Adherent-invasive Escherichia coli: a putative new E. coli pathotype associated with Crohn's disease

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https://api.crossref.org/works/10.1038%2FNCPGASTHEP0528

7 January 2021

Low-dose oral ferrous fumarate aggravated intestinal inflammation in rats with DSS-induced colitis.

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https://api.crossref.org/works/10.1038%2FNCPGASTHEP0528

7 January 2021

Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial

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7 January 2021

Trichuris suis therapy in Crohn's disease

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7 January 2021

Heligmosomoides polygyrus inhibits established colitis in IL-10-deficient mice.

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7 January 2021

Is Crohn's disease an immunodeficiency? A hypothesis suggesting possible early events in the pathogenesis of Crohn's disease

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7 January 2021

Sargramostim for active Crohn's disease

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7 January 2021

Immune regulation in the intestine: a balancing act between effector and regulatory T cell responses

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7 January 2021

Gene disruption and immunity in experimental colitis

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7 January 2021

Regulatory T cells: peace keepers in the gut.

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7 January 2021

The immunological and genetic basis of inflammatory bowel disease

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7 January 2021

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7 January 2021

Failure to induce oral tolerance to a soluble protein in patients with inflammatory bowel disease

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7 January 2021

Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease

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7 January 2021

Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

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7 January 2021

Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells

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7 January 2021

Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing

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7 January 2021

Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis.

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7 January 2021

Cdcs1, a Major Colitogenic Locus in Mice, Regulates Innate and Adaptive Immune Response to Enteric Bacterial Antigens

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7 January 2021

Decreased Bax expression by mucosal T cells favours resistance to apoptosis in Crohn's disease

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7 January 2021

Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

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7 January 2021

T cell apoptosis and inflammatory bowel disease

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https://api.crossref.org/works/10.1038%2FNCPGASTHEP0528

7 January 2021

CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes

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https://api.crossref.org/works/10.1038%2FNCPGASTHEP0528

7 January 2021

Induction of T lymphocyte apoptosis by sulphasalazine in patients with Crohn's disease.

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0528

7 January 2021

Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0528

7 January 2021

Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease.

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0528

7 January 2021

Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0528

7 January 2021

Identifiers

DOI

10.1038/NCPGASTHEP0528

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

945945

1007971314

0 references

Fatcat ID

release_moopqngqdvaifgnhzegkltcfxy

0 references

945945

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference