NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses (Q28588300)

Tumor necrosis factor

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Proto-oncogene c-Rel

1 reference

Interleukin 12a

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Nucleotide-binding oligomerization domain containing 2

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Interleukin 12 receptor, beta 1

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Interferon gamma

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Interleukin 10

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Interleukin 18

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Interleukin 12 receptor, beta 2

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V-rel reticuloendotheliosis viral oncogene homolog A (avian)

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Interleukin 12b

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Nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105

1 reference

author name string

Tomohiro Watanabe

1

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31 January 2017

Atsushi Kitani

2

1 reference

31 January 2017

Peter J. Murray

3

1 reference

31 January 2017

Warren Strober

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

4

1 reference

31 January 2017

language of work or name

English

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publication date

1 August 2004

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31 January 2017

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31 January 2017

5

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31 January 2017

800–808

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31 January 2017

8

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31 January 2017

1 reference

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

21 April 2017

1 reference

Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease

21 April 2017

1 reference

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

21 April 2017

1 reference

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

21 April 2017

1 reference

Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB

21 April 2017

1 reference

Role of Nod2 in the Response of Macrophages to Toll-Like Receptor Agonists

21 April 2017

1 reference

Toll-like receptor (TLR) 2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-kappa B activation and chemokine expression by epithelial cells

21 April 2017

1 reference

Lessons from Nod2 studies: towards a link between Crohn's disease and bacterial sensing

21 April 2017

1 reference

Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan

21 April 2017

1 reference

An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

21 April 2017

1 reference

Toll-like receptors: critical proteins linking innate and acquired immunity

21 April 2017

1 reference

The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease

21 April 2017

1 reference

NODs: intracellular proteins involved in inflammation and apoptosis

21 January 2018

1 reference

Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation

21 January 2018

1 reference

Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains

21 January 2018

1 reference

Toll-like receptor signaling

21 January 2018

1 reference

Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases.

21 January 2018

1 reference

Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan

21 January 2018

1 reference

The immunological and genetic basis of inflammatory bowel disease

21 January 2018

1 reference

The immunology of mucosal models of inflammation

21 January 2018

1 reference

The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease

21 January 2018

1 reference

Involvement of IRAK-M in peptidoglycan-induced tolerance in macrophages

21 January 2018

1 reference

Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation

21 January 2018

1 reference

CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells

21 January 2018

1 reference

Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors

21 January 2018

1 reference

The Lip lipoprotein from Neisseria gonorrhoeae stimulates cytokine release and NF-kappaB activation in epithelial cells in a Toll-like receptor 2-dependent manner.

21 January 2018

1 reference

Distinct roles for the NF-kappaB1 (p50) and c-Rel transcription factors in inflammatory arthritis

21 January 2018

1 reference

Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages

21 January 2018

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c-Rel regulates interleukin 12 p70 expression in CD8(+) dendritic cells by specifically inducing p35 gene transcription.

21 January 2018

1 reference

Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice

21 January 2018

1 reference

Synergistic effect of muramyldipeptide with lipopolysaccharide or lipoteichoic acid to induce inflammatory cytokines in human monocytic cells in culture

21 January 2018

1 reference

The origin of the synergistic effect of muramyl dipeptide with endotoxin and peptidoglycan

21 January 2018

1 reference

A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group.

21 January 2018

1 reference

T helper type 2 cell differentiation occurs in the presence of interleukin 12 receptor beta2 chain expression and signaling

21 January 2018

1 reference

Transforming growth factor (TGF)-beta1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-beta1-mediated fibrosis

21 January 2018

1 reference

HVJ-envelope vector for gene transfer into central nervous system

21 January 2018

1 reference

Cloning, sequencing and expression analysis of the mouse NOD2/CARD15 gene

21 January 2018

1 reference

Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations

21 January 2018

1 reference

Induction of Nod2 in Myelomonocytic and Intestinal Epithelial Cells via Nuclear Factor-κB Activation

21 January 2018

1 reference

7 January 2021

Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells

1 reference

7 January 2021

Interleukin 18 is a potent proliferative factor for intestinal mucosal lymphocytes in Crohn's disease

1 reference

7 January 2021

Distinct pathways for NF-kappa B regulation are associated with aberrant macrophage IL-12 production in lupus- and diabetes-prone mouse strains

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7 January 2021

CpG motifs of bacterial DNA exacerbate colitis of dextran sulfate sodium-treated mice

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7 January 2021

Administration of an antigen at a high dose generates regulatory CD4+ T cells expressing CD95 ligand and secreting IL-4 in the liver

1 reference

7 January 2021

CD40 ligation conditions dendritic cell antigen-presenting function through sustained activation of NF-kappaB

1 reference

7 January 2021