Understanding nature's catalytic toolkit (Q22251469)

Europe PubMed Central

title

Understanding nature's catalytic toolkit (English)

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2

Janet M Thornton

Janet M

Thornton

1 reference

PubMed

PubMed publication ID

7 February 2023

1

Alex Gutteridge

Alex

Gutteridge

1 reference

PubMed

PubMed publication ID

16214343

7 February 2023

language of work or name

English

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publication date

November 2005

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number of pages

8

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Trends in Biochemical Sciences

inferred from page(s)

published in

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volume

30

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issue

11

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page(s)

622-629

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cites work

Understanding noncovalent interactions: ligand binding energy and catalytic efficiency from ligand-induced reductions in motion within receptors and enzymes

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Crystal structures of Bacillus stearothermophilus adenylate kinase with bound Ap5A, Mg2+ Ap5A, and Mn2+ Ap5A reveal an intermediate lid position and six coordinate octahedral geometry for bound Mg2+ and Mn2+

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Kunitz-type soybean trypsin inhibitor revisited: refined structure of its complex with porcine trypsin reveals an insight into the interaction between a homologous inhibitor from Erythrina caffra and tissue-type plasminogen activator

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Protein structure to function: insights from computation.

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Zinc hydrolases: the mechanisms of zinc-dependent deacetylases

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Electron transfer by diflavin reductases.

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Searching for functional sites in protein structures.

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Conformational change in substrate binding, catalysis and product release: an open and shut case?

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Structural and catalytic diversity in the two family 11 aldo-keto reductases.

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Conformational changes observed in enzyme crystal structures upon substrate binding

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Using a library of structural templates to recognise catalytic sites and explore their evolution in homologous families

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Progress of structural genomics initiatives: an analysis of solved target structures.

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

The catalytic mechanism of indole-3-glycerol phosphate synthase: crystal structures of complexes of the enzyme from Sulfolobus solfataricus with substrate analogue, substrate, and product

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

A novel combination of two classic catalytic schemes

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Analysis of catalytic residues in enzyme active sites

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

So do we understand how enzymes work?

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Involvement of the C terminus in intramolecular nitrogen channeling in glucosamine 6-phosphate synthase: evidence from a 1.6 A crystal structure of the isomerase domain

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Tyrosine-derived quinone cofactors

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Structure of the IIA domain of the glucose permease of Bacillus subtilis at 2.2-A resolution.

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

PK of the lysine amino group at the active site of acetoacetate decarboxylase

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Multiple conformational changes in enzyme catalysis

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Crystal structure of sucrose phosphorylase from Bifidobacterium adolescentis

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Serine protease mechanism and specificity

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Ab initio QM/MM dynamics simulation of the tetrahedral intermediate of serine proteases: insights into the active site hydrogen-bonding network

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Role of Asp102 in the catalytic relay system of serine proteases: a theoretical study

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

On the magnitude and specificity of medium effects in enzyme-like catalysts for proton transfer

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Metallo-enzyme catalysis

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Crystal structure of cardosin A, a glycosylated and Arg-Gly-Asp-containing aspartic proteinase from the flowers of Cynara cardunculus L

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Structural basis of perturbed pKa values of catalytic groups in enzyme active sites

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

The Protein Data Bank

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Assigning genomic sequences to CATH

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

The Catalytic Site Atlas: a resource of catalytic sites and residues identified in enzymes using structural data

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Atomic resolution structure of Erwinia chrysanthemi L-asparaginase

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Direct experimental observation of the hydrogen-bonding network of a glycosidase along its reaction coordinate revealed by atomic resolution analyses of endoglucanase Cel5A

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

The mechanism of aconitase: 1.8 A resolution crystal structure of the S642a:citrate complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

The mechanism of sugar phosphate isomerization by glucosamine 6-phosphate synthase

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Computational design of a biologically active enzyme

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Computational thermostabilization of an enzyme

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021

Divergent evolution of enzymatic function: mechanistically diverse superfamilies and functionally distinct suprafamilies

1 reference

https://api.crossref.org/works/10.1016%2FJ.TIBS.2005.09.006

7 January 2021