Conformational change in substrate binding, catalysis and product release: an open and shut case? (Q35785856)

10 August 2017

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title

Conformational change in substrate binding, catalysis and product release: an open and shut case? (English)

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10 August 2017

2

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10 August 2017

Alex Gutteridge

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language of work or name

English

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publication date

1 June 2004

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10 August 2017

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10 August 2017

567

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10 August 2017

1

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10 August 2017

67-73

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10 August 2017

The Protein Data Bank

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

Anatomy of a conformational change: hinged "lid" motion of the triosephosphate isomerase loop.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

Space-Filling Models of Kinase Clefts and Conformation Changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

A database of macromolecular motions

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

Movable lobes and flexible loops in proteins. Structural deformations that control biochemical activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

Multiple conformational changes in enzyme catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

Analysis of catalytic residues in enzyme active sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

Crystal structure of naphthalene dioxygenase: side-on binding of dioxygen to iron

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

X-ray structure of yeast Hal2p, a major target of lithium and sodium toxicity, and identification of framework interactions determining cation sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

Structural enzymology of Li(+)-sensitive/Mg(2+)-dependent phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

Steric and conformational features of the aconitase mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

Iron center, substrate recognition and mechanism of peptide deformylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

The crystal structures of four peptide deformylases bound to the antibiotic actinonin reveal two distinct types: a platform for the structure-based design of antibacterial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

The catalytic pathway of cytochrome p450cam at atomic resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

Reaction path of protein farnesyltransferase at atomic resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

The additivity of substrate fragments in enzyme-ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

Water-mediated substrate/product discrimination: the product complex of thymidylate synthase at 1.83 A

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

Conformational dynamics along an enzymatic reaction pathway: thymidylate synthase, "the movie".

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

Mechanism of an ATP-dependent carboxylase, dethiobiotin synthetase, based on crystallographic studies of complexes with substrates and a reaction intermediate

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

Conformational changes on substrate binding to methylmalonyl CoA mutase and new insights into the free radical mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

Crystal structure of substrate complexes of methylmalonyl-CoA mutase

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

Conformational changes: how small is big enough?

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

Evolution of enzyme function and the development of catalytic efficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

Structure of dethiobiotin synthetase at 0.97 Å resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.03.067

10.1016/J.FEBSLET.2004.03.067

21 January 2018

Identifiers

DOI

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10 August 2017

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PubMed ID

15165895