Antioxidative Protection by Melatonin: Multiplicity of Mechanisms from Radical Detoxification to Radical Avoidance (Q22306050)

Europe PubMed Central

title

Antioxidative Protection by Melatonin: Multiplicity of Mechanisms from Radical Detoxification to Radical Avoidance (English)

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Rüdiger Hardeland

Rüdiger

Hardeland

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Dimensions Publication ID

Dimensions

1030310096

Relationships between melatonin, glutathione peroxidase, glutathione reductase, and catalase. Endogenous rhythms on cerebral cortex in Gallus domesticus

7 February 2023

publication date

2005

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27

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page(s)

119-130

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issue

2

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cites work

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N1-acetyl-N2-formyl-5-methoxykynuramine, a biogenic amine and melatonin metabolite, functions as a potent antioxidant.

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Melatonin and structurally-related, endogenous indoles act as potent electron donors and radical scavengers in vitro

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Melatonin increases glutathione peroxidase activity and deformability of erythrocytes in septic rats

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Increased brain damage after stroke or excitotoxic seizures in melatonin-deficient rats.

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Molecular evidence that melatonin is enzymatically oxidized in a different manner than tryptophan: investigations with both indoleamine 2,3-dioxygenase and myeloperoxidase

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Antioxidant actions of melatonin

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Melatonin improved the disturbances in hepatic prooxidant and antioxidant balance and hepatotoxicity induced by a high cholesterol diet in C57BL/6J mice

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Melatonin receptors and their regulation: biochemical and structural mechanisms

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Melatonin attenuates kainic acid-induced hippocampal neurodegeneration and oxidative stress through microglial inhibition

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Melatonin and 5-methoxytryptamine in non-metazoans

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Circadian rhythms, oxidative stress, and antioxidative defense mechanisms

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Neurohormone melatonin prevents cell damage: effect on gene expression for antioxidant enzymes.

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Regulation of the kynurenine pathway by IFN-gamma in murine cloned macrophages and microglial cells

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Oxidative damage in the central nervous system: protection by melatonin

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Effect of pineal indoles on activities of the antioxidant defense enzymes superoxide dismutase, catalase, and glutathione reductase, and levels of reduced and oxidized glutathione in rat tissues

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Effect of melatonin cotreatment against kainic acid on coenzyme Q10, lipid peroxidation and Trx mRNA in rat hippocampus

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Reactive oxygen and nitrogen species and cellular and organismal decline: amelioration with melatonin

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Time course of the melatonin-induced increase in glutathione peroxidase activity in chick tissues

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Protective effect of melatonin on experimental spinal cord ischemia

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Hepatic mitochondrial dysfunction in senescence-accelerated mice: correction by long-term, orally administered physiological levels of melatonin

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Melatonin protects hepatic mitochondrial respiratory chain activity in senescence-accelerated mice

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Hydroxyl radical reaction with melatonin molecule: a computational study.

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A review of the evidence supporting melatonin's role as an antioxidant

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Melatonin counteracts lipopolysaccharide-induced expression and activity of mitochondrial nitric oxide synthase in rats

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Oxidative stress as a mechanism for quinolinic acid-induced hippocampal damage: protection by melatonin and deprenyl

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Effects of age and dietary antioxidants on cerebral electron transport chain activity

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Anticonvulsant activity of melatonin against seizures induced by quinolinate, kainate, glutamate, NMDA, and pentylenetetrazole in mice.

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Acutely administered melatonin restores hepatic mitochondrial physiology in old mice

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Maternally administered melatonin protects against ischemia and reperfusion-induced oxidative mitochondrial damage in premature fetal rat brain

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Melatonin plays a protective role in quinolinic acid-induced neurotoxicity in the rat hippocampus

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Melatonin, active oxygen species and neurological damage

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Melatonin reduces oxidative damage of neural lipids and proteins in senescence-accelerated mouse

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The effect of melatonin on liver superoxide dismutase activity, serum nitrate and thyroid hormone levels

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Changes in the sleep-wake cycle architecture and cortical nitric oxide release during ageing in the rat.

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Effects of Exogenous Melatonin—A Review

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High melatonin solubility in aqueous medium

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Melatonin increases gene expression for antioxidant enzymes in rat brain cortex.

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Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum

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Oxidative processes and antioxidative defense mechanisms in the aging brain

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Photocatalytic actions of the pesticide metabolite 2-hydroxyquinoxaline: destruction of antioxidant vitamins and biogenic amines - implications of organic redox cycling

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Melatonin protection against lethal myocyte injury induced by doxorubicin as reflected by effects on mitochondrial membrane potential

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Early upregulation of hippocampal 5-lipoxygenase following systemic administration of kainate to rats.

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Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of ATP in rat brain and liver mitochondria

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Melatonin ameliorates neurologic damage and neurophysiologic deficits in experimental models of stroke

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Regulation of antioxidant enzymes: a significant role for melatonin

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Melatonin prevents disruption of hepatic reactive oxygen species metabolism in rats treated with carbon tetrachloride

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Melatonin increases activities of glutathione peroxidase and superoxide dismutase in fetal rat brain

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Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti-apoptotic effects of melatonin

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Melatonin reduces nitric oxide synthase activity in rat hypothalamus

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Reaction of peroxynitrite with melatonin: A mechanistic study

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In vivo changes in antioxidant systems and protective role of melatonin and a combination of vitamin C and vitamin E on oxidative damage in erythrocytes induced by chlorpyrifos-ethyl in rats

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Protective effect of melatonin on random pattern skin flap necrosis in pinealectomized rat.

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Oxidation of melatonin by oxoferryl hemoglobin: a mechanistic study

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Pro-oxidant activity of aluminum in the rat hippocampus: gene expression of antioxidant enzymes after melatonin administration

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Melatonin: an endogenous negative modulator of 12-lipoxygenation in the rat pineal gland

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Melatonin reduces non-adrenergic, non-cholinergic relaxant neurotransmission by inhibition of nitric oxide synthase activity in the gastrointestinal tract of rodents in vitro

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Melatonin protects against delta-aminolevulinic acid-induced oxidative damage in male Syrian hamster Harderian glands

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Neuroprotective action of melatonin on neonatal rat motoneurons after sciatic nerve transection

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Effects of the circadian mutation 'tau' on the Harderian glands of Syrian hamsters

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The reaction of melatonin with peroxynitrite: formation of melatonin radical cation and absence of stable nitrated products

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Nitrosation of melatonin by nitric oxide: a computational study.

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Melatonin as a radioprotective agent: a review

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In vitro and in vivo formation of two new metabolites of melatonin.

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Non-vertebrate melatonin.

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The enzyme indoleamine 2,3-dioxygenase is induced in the mouse brain in response to peripheral administration of lipopolysaccharide and superantigen.

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A novel melatonin metabolite, cyclic 3-hydroxymelatonin: a biomarker of in vivo hydroxyl radical generation

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Physiological oxidative stress model: Syrian hamster Harderian gland-sex differences in antioxidant enzymes.

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Melatonin and mitochondrial function

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Potent neuroprotective properties against the Alzheimer beta-amyloid by an endogenous melatonin-related indole structure, indole-3-propionic acid

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N-acetyl-5-methoxy kynurenamine, a brain metabolite of melatonin, is a potent inhibitor of prostaglandin biosynthesis

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Mechanistic and comparative studies of melatonin and classic antioxidants in terms of their interactions with the ABTS cation radical.

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Oxidative damage to nuclear DNA: amelioration by melatonin. NEL Review

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12 December 2020

Endogenous rhythms of melatonin, total antioxidant status and superoxide dismutase activity in several tissues of chick and their inhibition by light

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12 December 2020

Melatonin stimulates glutathione peroxidase activity in human chorion

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12 December 2020

Oxidative toxicity in models of neurodegeneration: responses to melatonin.

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12 December 2020

Melatonin, mitochondria, and cellular bioenergetics

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The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo

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12 December 2020

Comparative pharmacological studies of melatonin receptors: MT1, MT2 and MT3/QR2. Tissue distribution of MT3/QR2 .

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12 December 2020

DNA oxidatively damaged by chromium(III) and H(2)O(2) is protected by the antioxidants melatonin, N(1)-acetyl-N(2)-formyl-5-methoxykynuramine, resveratrol and uric acid

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12 December 2020

Rhythms of glutathione peroxidase and glutathione reductase in brain of chick and their inhibition by light.

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12 December 2020

Oxidation of melatonin by carbonate radicals and chemiluminescence emitted during pyrrole ring cleavage

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12 December 2020

Distribution of melatonin in mammalian tissues: the relative importance of nuclear versus cytosolic localization

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12 December 2020

Protective effect of melatonin against mitochondrial injury induced by ischemia and reperfusion of rat liver

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12 December 2020

Melatonin stimulates the activity of protective antioxidative enzymes in myocardial cells of rats in the course of doxorubicin intoxication

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12 December 2020

Free radical-mediated molecular damage. Mechanisms for the protective actions of melatonin in the central nervous system

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Coadministration of melatonin and estradiol in rats: effects on oxidant status

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Identification of the melatonin-binding site MT3 as the quinone reductase 2.

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12 December 2020

Circadian variation of nitric oxide synthase activity in mouse tissue.

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Melatonin-induced increased activity of the respiratory chain complexes I and IV can prevent mitochondrial damage induced by ruthenium red in vivo

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12 December 2020

Melatonin reduces oxidative neurotoxicity due to quinolinic acid:

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12 December 2020

Melatonin--a highly potent endogenous radical scavenger and electron donor: new aspects of the oxidation chemistry of this indole accessed in vitro

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12 December 2020

Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans

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Melatonin oxidative stress and neurodegenerative diseases.

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Antioxidative effects of melatonin in protection against cellular damage caused by ionizing radiation

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Protective effect of melatonin on antioxidative system in experimental ischemia-reperfusion of rat small intestine

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12 December 2020

The effects of melatonin on the antioxidant systems in experimental spinal injury

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12 December 2020

New actions of melatonin and their relevance to biometeorology

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Melatonin protects fetal rat brain against oxidative mitochondrial damage

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Pharmacological actions of melatonin in acute and chronic inflammation

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12 December 2020

Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger.

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12 December 2020

Melatonin attenuates the neuronal NADPH-d/NOS expression in the nodose ganglion of acute hypoxic rats

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12 December 2020

Tissue retention and subcellular distribution of continuously infused melatonin in rats under near physiological conditions.

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12 December 2020

Significance of melatonin in antioxidative defense system: reactions and products

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12 December 2020

Radical metabolism is partner to energy metabolism in mitochondria

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12 December 2020

Melatonin inhibits expression of the inducible isoform of nitric oxide synthase in murine macrophages: role of inhibition of NFkappaB activation.

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12 December 2020

Melatonin mitigates mitochondrial malfunction

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12 December 2020

Pharmacological utility of melatonin in reducing oxidative cellular and molecular damage.

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12 December 2020