NPC intracellular cholesterol transporter 2 (Q22678624)

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mammalian protein found in Homo sapiens

epididymis secretory sperm binding protein
human epididymis-specific protein 1
He1
epididymal protein 1
Niemann-Pick disease type C2 protein
tissue-specific secretory protein
NPC2
epididymal secretory protein E1

Language	Label	Description	Also known as
English	NPC intracellular cholesterol transporter 2	mammalian protein found in Homo sapiens	epididymis secretory sperm binding protein human epididymis-specific protein 1 He1 epididymal protein 1 Niemann-Pick disease type C2 protein tissue-specific secretory protein NPC2 epididymal secretory protein E1

Statements

1 reference

13 November 2019

UniProt protein ID

Epididymal secretory protein E1

1 reference

Transporter Classification Database ID

30 September 2019

based on heuristic

hierarchical database ID heuristic

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method

1 reference

9 May 2019

In vivo interaction between the human dehydrodolichyl diphosphate synthase and the Niemann-Pick C2 protein revealed by a yeast two-hybrid system

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

cholesterol binding

determination method

4 references

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

1 January 2018

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

1 January 2018

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

1 January 2018

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

protein binding

determination method

3 references

9 May 2019

Identification of NPC2 protein as interaction molecule with C2 domain of human Nedd4L

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

9 May 2019

Novel function of Niemann-Pick C1-like 1 as a negative regulator of Niemann-Pick C2 protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

9 May 2019

The new obesity-associated protein, neuronal growth regulator 1 (NEGR1), is implicated in Niemann-Pick disease Type C (NPC2)-mediated cholesterol trafficking

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

cholesterol transfer activity

determination method

cholesterol binding

determination method

3 references

8 April 2019

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

8 April 2019

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

8 April 2019

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

cholesterol binding

determination method

4 references

9 May 2019

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

9 May 2019

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

9 May 2019

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

cholesterol transfer activity

determination method

3 references

9 May 2019

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

9 May 2019

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

9 May 2019

Niemann-Pick type C disease: subcellular location and functional characterization of NPC2 proteins with naturally occurring missense mutations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

9 May 2019

Identification of HE1 as the second gene of Niemann-Pick C disease

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

extracellular exosome

determination method

endoplasmic reticulum

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

extracellular space

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916

determination method

azurophil granule lumen

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

lysosomal lumen

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

extracellular space

determination method

1 reference

9 May 2019

Niemann-Pick type C disease: subcellular location and functional characterization of NPC2 proteins with naturally occurring missense mutations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

extracellular exosome

determination method

1 reference

9 May 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

biological process

intracellular sterol transport

determination method

1 reference

9 May 2019

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

regulation of isoprenoid metabolic process

determination method

1 reference

9 May 2019

In vivo interaction between the human dehydrodolichyl diphosphate synthase and the Niemann-Pick C2 protein revealed by a yeast two-hybrid system

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

phospholipid transport

determination method

1 reference

9 May 2019

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

cholesterol transport

determination method

3 references

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

1 January 2018

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

1 January 2018

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

response to virus

determination method

1 reference

9 May 2019

Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

cholesterol homeostasis

determination method

1 reference

26 September 2017

NPC1 and NPC2 Regulate Cellular Cholesterol Homeostasis through Generation of Low Density Lipoprotein Cholesterol-derived Oxysterols

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916

determination method

steroid metabolic process

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

glycolipid transport

determination method

1 reference

9 May 2019

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

intracellular cholesterol transport

determination method

5 references

26 September 2017

Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916

determination method

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916

determination method

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916

determination method

26 September 2017

Regulation of sterol transport between membranes and NPC2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916

determination method

26 September 2017

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916

determination method

cholesterol metabolic process

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

lipid metabolism

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

neutrophil degranulation

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

low-density lipoprotein particle clearance

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

lipid transport

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

intracellular cholesterol transport

determination method

6 references

8 April 2019

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

8 April 2019

Niemann-Pick type C disease: subcellular location and functional characterization of NPC2 proteins with naturally occurring missense mutations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

8 April 2019

Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

8 April 2019

Regulation of sterol transport between membranes and NPC2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

8 April 2019

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

cholesterol homeostasis

determination method

cholesterol transport

determination method

cholesterol efflux

determination method

1 reference

8 April 2019

Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

sterol transport

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

intracellular cholesterol transport

determination method

7 references

9 May 2019

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

9 May 2019

Niemann-Pick type C disease: subcellular location and functional characterization of NPC2 proteins with naturally occurring missense mutations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

9 May 2019

Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

9 May 2019

Regulation of sterol transport between membranes and NPC2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

9 May 2019

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000442488

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000442488

ENSP00000451112

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000451112

ENSP00000238633

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000238633

ENSP00000412103

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000412103

ENSP00000450502

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000450502

ENSP00000450887

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000450887

ENSP00000451180

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000451180

ENSP00000451206

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000451206

ENSP00000451314

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000451314

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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