NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes (Q24310567)

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13 January 2020

title

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes (English)

1 reference

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NPC intracellular cholesterol transporter 2

13 January 2020

main subject

1 reference

NPC intracellular cholesterol transporter 1

GOA release 2020-03-11

1 reference

cholesterol transfer activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Arun Radhakrishnan

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18772377%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

6

Joseph L Goldstein

1 reference

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13 January 2020

author name string

Rodney E Infante

1

1 reference

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13 January 2020

Michael L Wang

2

1 reference

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13 January 2020

Hyock Joo Kwon

4

1 reference

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13 January 2020

Michael S Brown

5

1 reference

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13 January 2020

language of work or name

English

0 references

publication date

4 September 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18772377%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

13 January 2020

published in

1 reference

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13 January 2020

volume

105

1 reference

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13 January 2020

issue

40

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13 January 2020

page(s)

15287-15292

1 reference

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Structure of a cholesterol-binding protein deficient in Niemann-Pick type C2 disease

13 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563079

Identification of HE1 as the second gene of Niemann-Pick C disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563079

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563079

Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563079

Structural Basis of Sterol Binding by NPC2, a Lysosomal Protein Deficient in Niemann-Pick Type C2 Disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563079

A receptor-mediated pathway for cholesterol homeostasis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563079

Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563079

Niemann-Pick type C disease: importance of N-glycosylation sites for function and cellular location of the NPC2 protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563079

Niemann-Pick C research from mouse to gene

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563079

The integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563079

Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563079

Localization of 3-hydroxy-3-methylglutaryl CoA reductase and 3-hydroxy-3-methylglutaryl CoA synthase in the rat liver and intestine is affected by cholestyramine and mevinolin.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2563079

Development of an assay for the intermembrane transfer of cholesterol by Niemann-Pick C2 protein

30 May 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0807328105

Mechanism of cholesterol transfer from the Niemann-Pick type C2 protein to model membranes supports a role in lysosomal cholesterol transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0807328105

Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0807328105

Niemann-Pick C disease: functional characterization of three NPC2 mutations and clinical and molecular update on patients with NPC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0807328105

Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0807328105

21 January 2018

Identifiers

DOI

10.1073/PNAS.0807328105

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18772377%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

ADS bibcode

2008PNAS..10515287I

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18772377%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

2 references