Human recombinant activated protein C for severe sepsis (Q24201123)

1

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Ivan Solà

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Andrés Felipe Cardona

4

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author name string

Dimitrios Lathyris

Cochrane Database of Systematic Reviews

3

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publication date

14 March 2012

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published in

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cites work

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Use of Drotrecogin alfa (activated) in Italian intensive care units: the results of a nationwide survey

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Early drotrecogin alpha (activated) administration in severe sepsis is associated with lower mortality: a retrospective analysis of the Canadian ENHANCE cohort

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Cost-effectiveness of drotrecogin alfa (activated) for the treatment of severe sepsis in Germany

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A meta-analysis of controlled trials of recombinant human activated protein C therapy in patients with sepsis

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21 January 2018

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GRADE guidelines: 3. Rating the quality of evidence

21 January 2018

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Racial variation in the incidence, care, and outcomes of severe sepsis: analysis of population, patient, and hospital characteristics

21 January 2018

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Scope and impact of financial conflicts of interest in biomedical research: a systematic review

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21 January 2018

Antibiotics in sepsis

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21 January 2018

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A pilot randomized study comparing high and low volume hemofiltration on vasopressor use in septic shock

21 January 2018

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Mechanisms of action of recombinant human activated Protein C

21 January 2018

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Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. French ICU Group for Severe Sepsis

21 January 2018

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Sepsis: time to reconsider the concept

21 January 2018

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Molecular biology of inflammation and sepsis: a primer

21 January 2018

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Non-antibiotic strategies for sepsis

21 January 2018

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Diagnosis of infection in sepsis: an evidence-based review

21 January 2018

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The puzzle of sepsis: fitting the pieces of the inflammatory response with treatment

21 January 2018

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21 January 2018

New therapies for sepsis

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Critical advances in septicemia and septic shock

21 January 2018

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Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008

21 January 2018

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Inflammation and the activated protein C anticoagulant pathway

21 January 2018

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The endothelial protein C receptor

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Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock.

21 January 2018

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Protein C levels as a prognostic indicator of outcome in sepsis and related diseases

21 January 2018

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Disseminated intravascular coagulation (DIC) diagnosed based on the Japanese Association for Acute Medicine criteria is a dependent continuum to overt DIC in patients with sepsis.

21 January 2018

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Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis.

21 January 2018

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Timing of adequate antibiotic therapy is a greater determinant of outcome than are TNF and IL-10 polymorphisms in patients with sepsis

21 January 2018

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Historical perspective of the word "sepsis".

21 January 2018

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Pharmacological treatment of sepsis

21 January 2018

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International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics

21 January 2018

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Incidence and impact of organ dysfunctions associated with sepsis

21 January 2018

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What is "quality of evidence" and why is it important to clinicians?

21 January 2018

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GRADE guidelines: 2. Framing the question and deciding on important outcomes.

21 January 2018

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GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables

21 January 2018

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GRADE guidelines: 4. Rating the quality of evidence--study limitations (risk of bias)

21 January 2018

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GRADE guidelines: 9. Rating up the quality of evidence

21 January 2018

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GRADE guidelines: 8. Rating the quality of evidence--indirectness

21 January 2018

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GRADE guidelines: 7. Rating the quality of evidence--inconsistency

21 January 2018

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GRADE guidelines 6. Rating the quality of evidence—imprecision

21 January 2018

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GRADE guidelines: 5. Rating the quality of evidence--publication bias

21 January 2018

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New and emerging therapies for sepsis

21 January 2018

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Measuring inconsistency in meta-analyses

21 January 2018

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Treatment of sepsis with activated protein C.

21 January 2018

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Microhemodynamic and cellular mechanisms of activated protein C action during endotoxemia

21 January 2018

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Genetic polymorphisms in sepsis and septic shock: role in prognosis and potential for therapy

21 January 2018

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Immunotherapy for sepsis--a new approach against an ancient foe.

21 January 2018

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New insight in LPS antagonist

21 January 2018

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[Epidemiology and costs of severe sepsis in Madrid. A hospital discharge study].

21 January 2018

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Cochrane reviews compared with industry supported meta-analyses and other meta-analyses of the same drugs: systematic review

21 January 2018

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Recombinant human activated protein C for severe sepsis in neonates

21 January 2018

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Discovery and development of toll-like receptor 4 (TLR4) antagonists: a new paradigm for treating sepsis and other diseases

21 January 2018

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Emerging drugs in sepsis.

21 January 2018

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The coagulant response in sepsis

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Pharmaceutical industry sponsorship and research outcome and quality: systematic review

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Implications of pharmaceutical industry funding on clinical research.

21 January 2018

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Protein C in critical illness

21 January 2018

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Source control in the management of severe sepsis and septic shock: an evidence-based review

21 January 2018

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Sepsis: rethinking the approach to clinical research

21 January 2018

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Vascular biology in sepsis: pathophysiological and therapeutic significance of vascular dysfunction

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Evidence b(i)ased medicine--selective reporting from studies sponsored by pharmaceutical industry: review of studies in new drug applications

21 January 2018

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The cytoprotective protein C pathway

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Protective mechanisms of activated protein C in severe inflammatory disorders.

21 January 2018

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Experimental therapeutic strategies for severe sepsis: mediators and mechanisms

21 January 2018

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Is there a treatment for sepsis other than antibiotics?

21 January 2018

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The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study

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Early goal-directed therapy: an evidence-based review.

21 January 2018

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Science review: role of coagulation protease cascades in sepsis

21 January 2018

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Pathogenesis-oriented targets for adjunctive therapy

21 January 2018

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Harmful molecular mechanisms in sepsis

21 January 2018

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Controversies in the treatment of sepsis

21 January 2018

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Activated protein C action in inflammation

21 January 2018

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Protein C concentrations in severe sepsis: an early directional change in plasma levels predicts outcome

21 January 2018

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Protein C: a potential biomarker in severe sepsis and a possible tool for monitoring treatment with drotrecogin alfa (activated)

21 January 2018

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Corticosteroids in severe pneumonia

21 January 2018

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Organ dysfunction during sepsis

21 January 2018

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Effect of various genetic polymorphisms on the incidence and outcome of severe sepsis

21 January 2018

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Pharmaceutical company funding and its consequences: a qualitative systematic review

21 January 2018

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The immunology of sepsis.

21 January 2018

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Derangements of coagulation and fibrinolysis in critically ill patients with sepsis and septic shock

21 January 2018

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Reducing mortality in sepsis: new directions

21 January 2018

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Evidence-based medicine in the ICU: important advances and limitations

21 January 2018

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The coagulation cascade in sepsis

21 January 2018

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Novel HMGB1-inhibiting therapeutic agents for experimental sepsis

21 January 2018

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The apoptotic pathway as a therapeutic target in sepsis

21 January 2018

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Adjunctive therapies for severe sepsis

21 January 2018

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Activated protein C versus protein C in severe sepsis

21 January 2018

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Human recombinant activated protein C for severe sepsis

21 January 2018

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Human recombinant activated protein C for severe sepsis

21 January 2018

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Human recombinant activated protein C for severe sepsis

21 January 2018

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Biomarkers of thrombosis, fibrinolysis, and inflammation in patients with severe sepsis due to community-acquired pneumonia with and without Streptococcus pneumoniae

21 January 2018

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7 January 2021

[Potential benefits of non-anti-infective treatments of septic shock: a critical analysis of literature]

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7 January 2021

International integrated database for the evaluation of severe sepsis and drotrecogin alfa (activated) therapy: 28-day survival and safety

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7 January 2021

How pharmaceutical industry funding affects trial outcomes: causal structures and responses

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7 January 2021

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7 January 2021

Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis with multiple organ failure

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7 January 2021

The epidemiology of, and risk factors for, mortality from severe sepsis and septic shock in a tertiary-care university hospital setting

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7 January 2021

Recombinant human activated protein C in severe sepsis

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7 January 2021

Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis

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7 January 2021

Hospital mortality and resource use in subgroups of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) trial

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7 January 2021

Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: Further evidence for survival and safety and implications for early treatment*

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7 January 2021

Seasonal variation in the epidemiology of sepsis

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https://api.crossref.org/works/10.1002%2F14651858.CD004388.PUB5

7 January 2021

ADDRESS (ADministration of DRotrecogin alfa [activated] in Early stage Severe Sepsis) long-term follow-up: one-year safety and efficacy evaluation

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD004388.PUB5

7 January 2021

Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD004388.PUB5

7 January 2021

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD004388.PUB5

7 January 2021

Protective effects of activated protein C in sepsis

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD004388.PUB5

7 January 2021

Prophylactic heparin in patients with severe sepsis treated with drotrecogin alfa (activated)

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD004388.PUB5

7 January 2021

Drotrecogin alfa (activated) in sepsis: initial experience with patient selection, cost, and clinical outcomes

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD004388.PUB5

7 January 2021

Treatment of septic shock and use of drotrecogin alfa (activated) in children

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD004388.PUB5

7 January 2021

Pathophysiology of sepsis

1 reference

https://api.crossref.org/works/10.1002%2F14651858.CD004388.PUB5

7 January 2021

10.1002/14651858.CD004388.PUB5

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

22419295

1 reference

Consolidated OpenCitations Corpus – April 2017