Impact of the H275Y and I223V Mutations in the Neuraminidase of the 2009 Pandemic Influenza Virus In Vitro and Evaluating Experimental Reproducibility (Q24288661)

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English	Impact of the H275Y and I223V Mutations in the Neuraminidase of the 2009 Pandemic Influenza Virus In Vitro and Evaluating Experimental Reproducibility	scientific article

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8 March 2020

Impact of the H275Y and I223V Mutations in the Neuraminidase of the 2009 Pandemic Influenza Virus In Vitro and Evaluating Experimental Reproducibility (English)

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8 March 2020

reproducibility

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Catherine Beauchemin

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Guy Boivin

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Yacine Abed

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Eric G Paradis

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Lady Tatiana Pinilla

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Benjamin P Holder

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20 May 2015

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8 March 2020

e0126115

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Creative Commons Attribution 4.0 International

20 May 2015

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The quality of methods reporting in parasitology experiments

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19 March 2017

Reproducible Science

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Neuraminidase inhibitor resistance in influenza: assessing the danger of its generation and spread

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19 March 2017

Detection of oseltamivir-resistant pandemic influenza A(H1N1)pdm2009 in Brazil: can community transmission be ruled out?

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27 September 2017

I223R mutation in influenza A(H1N1)pdm09 neuraminidase confers reduced susceptibility to oseltamivir and zanamivir and enhanced resistance with H275Y

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The H275Y neuraminidase mutation of the pandemic A/H1N1 influenza virus lengthens the eclipse phase and reduces viral output of infected cells, potentially compromising fitness in ferrets.

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Comparable fitness and transmissibility between oseltamivir-resistant pandemic 2009 and seasonal H1N1 influenza viruses with the H275Y neuraminidase mutation.

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Impact of mutations at residue I223 of the neuraminidase protein on the resistance profile, replication level, and virulence of the 2009 pandemic influenza virus

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First Fatal Oseltamivir-Resistant 2009 Pandemic Influenza A (H1N1) Case in an Adult in Korea.

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27 September 2017

Neuraminidase inhibitor susceptibility testing in human influenza viruses: a laboratory surveillance perspective

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Multidrug resistant 2009 A/H1N1 influenza clinical isolate with a neuraminidase I223R mutation retains its virulence and transmissibility in ferrets

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Exploring the effect of biological delays in kinetic models of influenza within a host or cell culture

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10.1371/JOURNAL.PONE.0126115

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2015PLoSO..1026115P

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