Identification of new epilepsy treatments: issues in preclinical methodology (Q24289140)

6

0 references

Wolfgang Löscher

7

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Emilio Perucca

5

Emilio Perucca

0 references

Michele Simonato

Michele Simonato

13

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Solomon L. Moshé

Solomon L Moshé

4

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Jeffrey L. Noebels

Jeffrey L Noebels

8

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Terence J O'Brien

Terence J O'Brien

12

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Asla Pitkänen

9

Asla Pitkänen

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Aristea S Galanopoulou

1

Aristea S Galanopoulou

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author name string

Paul S Buckmaster

2

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Kevin J Staley

3

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James Stables

10

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H Steve White

Why most published research findings are false

11

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language of work or name

English

0 references

publication date

March 2012

0 references

published in

Epilepsia

0 references

volume

53

0 references

issue

3

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page(s)

571-82

0 references

cites work

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How common are the "common" neurologic disorders?

19 March 2017

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Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma

19 March 2017

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Phenomenology of prolonged febrile seizures: results of the FEBSTAT study

19 March 2017

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Biomarkers and surrogate endpoints: preferred definitions and conceptual framework

19 March 2017

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Believe it or not: how much can we rely on published data on potential drug targets?

19 March 2017

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Update of the stroke therapy academic industry roundtable preclinical recommendations

7 April 2017

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A pulse rapamycin therapy for infantile spasms and associated cognitive decline

7 April 2017

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Role of tissue plasminogen activator in acute ischemic stroke

27 September 2017

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Development of later life spontaneous seizures in a rodent model of hypoxia-induced neonatal seizures

27 September 2017

1 reference

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Mechanisms of epileptogenesis and potential treatment targets

27 September 2017

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Antiepileptic and antiepileptogenic performance of carisbamate after head injury in the rat: blind and randomized studies.

27 September 2017

1 reference

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Interictal spikes precede ictal discharges in an organotypic hippocampal slice culture model of epileptogenesis

27 September 2017

1 reference

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Role of biotransformation in drug-induced toxicity: influence of intra- and inter-species differences in drug metabolism

27 September 2017

1 reference

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Therapeutic approaches to epileptogenesis--hope on the horizon

27 September 2017

1 reference

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Epileptogenesis provoked by prolonged experimental febrile seizures: mechanisms and biomarkers

27 September 2017

1 reference

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When clinical trials make history: demonstrating efficacy of new antiepileptic drugs as monotherapy

27 September 2017

1 reference

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High-frequency oscillations in epileptic brain

27 September 2017

1 reference

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A model of symptomatic infantile spasms syndrome

27 September 2017

1 reference

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A triplet repeat expansion genetic mouse model of infantile spasms syndrome, Arx(GCG)10+7, with interneuronopathy, spasms in infancy, persistent seizures, and adult cognitive and behavioral impairment

27 September 2017

1 reference

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Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy

27 September 2017

1 reference

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Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human phenotype in heterozygous females

27 September 2017

1 reference

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Curing epilepsy: progress and future directions

27 September 2017

1 reference

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Development of spontaneous recurrent seizures after kainate-induced status epilepticus

27 September 2017

1 reference

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A re-assessment of minocycline as a neuroprotective agent in a rat spinal cord contusion model

27 September 2017

1 reference

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Developmental impact of a familial GABAA receptor epilepsy mutation

27 September 2017

1 reference

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Mechanisms of drug resistance in status epilepticus

27 September 2017

1 reference

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Progress in epilepsy: reducing the treatment gap and the promise of biomarkers

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3551973

A re-assessment of the effects of a Nogo-66 receptor antagonist on regenerative growth of axons and locomotor recovery after spinal cord injury in mice

27 September 2017

1 reference

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Development of new antiepileptic drugs: challenges, incentives, and recent advances

27 September 2017

1 reference

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Life after cerovive: a personal perspective on ischemic neuroprotection in the post-NXY-059 era.

27 September 2017

1 reference

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Monitoring gene changes during antiepileptic drug therapy to widen the safety window and reduce pharmacoresistance

27 September 2017

1 reference

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Lost in translation: treatment trials in the SOD1 mouse and in human ALS.

27 September 2017

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Discovery of antiepileptic drugs

27 September 2017

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Drug resistance in brain diseases and the role of drug efflux transporters.

27 September 2017

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Responsiveness of Status Epilepticus to Treatment with Diazepan Decreases Rapidly as Seizure Duration Increases

27 September 2017

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Preclinical development of antiepileptic drugs: past, present, and future directions

27 September 2017

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Recommendations for standards regarding preclinical neuroprotective and restorative drug development

27 September 2017

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Infantile spasms and Down syndrome: a new animal model

27 September 2017

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Posttraumatic epilepsy after controlled cortical impact injury in mice

30 May 2018

1 reference

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Recombinant human tissue-type plasminogen activator therapy in acute thromboembolic stroke.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3551973

Multiparametric ISODATA analysis of embolic stroke and rt-PA intervention in rat.

30 May 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03391.X

Biomarkers in epilepsy: introduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03391.X

Electroconvulsive thresholds of inbred mouse strains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03391.X

Masking epilepsy by combining two epilepsy genes.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03391.X

Antiepileptic treatment before the onset of seizures reduces epilepsy severity and risk of mental retardation in infants with tuberous sclerosis complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03391.X

Association of the severity of cortical damage with the occurrence of spontaneous seizures and hyperexcitability in an animal model of posttraumatic epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03391.X

A new animal model of infantile spasms with unprovoked persistent seizures.

21 January 2018

1 reference

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The United Kingdom Infantile Spasms Study (UKISS) comparing hormone treatment with vigabatrin on developmental and epilepsy outcomes to age 14 months: a multicentre randomised trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03391.X

Predictive value of cortical injury for the development of temporal lobe epilepsy in 21-day-old rats: an MRI approach using the lithium-pilocarpine model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03391.X

Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03391.X

Carisbamate as adjunctive treatment of partial onset seizures in adults in two randomized, placebo-controlled trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03391.X

Model of infantile spasms induced by N-methyl-D-aspartic acid in prenatally impaired brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03391.X

Prevention of seizure-induced sudden death in a chronic SUDEP model by semichronic administration of a selective serotonin reuptake inhibitor

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22292566

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Reliability of 'new drug target' claims called into question

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22292566

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/J.1528-1167.2011.03391.X

1 reference

release_5rl4jra765gzvpbutdh2jjghgu

1334645

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/5rl4jra765gzvpbutdh2jjghgu

mapped directly with Wikidata item

24 November 2022

based on heuristic

1334645

1 reference

1 reference

1 reference