Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing (Q24290265)

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10 November 2019

title

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing (English)

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10 November 2019

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GOA release 2020-03-11

author

Dazhong Xu

19

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10 November 2019

Lindsay A. Farrer

26

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Peter Henry St George-Hyslop

10 November 2019

30

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10 November 2019

author name string

Yu G

1

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10 November 2019

Nishimura M

2

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10 November 2019

Arawaka S

3

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10 November 2019

Levitan D

4

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10 November 2019

Zhang L

5

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10 November 2019

Tandon A

6

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10 November 2019

Song YQ

7

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10 November 2019

Rogaeva E

8

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10 November 2019

Chen F

9

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10 November 2019

Kawarai T

10

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10 November 2019

Supala A

11

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10 November 2019

Levesque L

12

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10 November 2019

Yu H

13

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10 November 2019

Yang DS

14

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10 November 2019

Holmes E

15

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10 November 2019

Milman P

16

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10 November 2019

Liang Y

17

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10 November 2019

Zhang DM

18

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10 November 2019

Sato C

20

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10 November 2019

Rogaev E

21

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10 November 2019

Smith M

22

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10 November 2019

Janus C

23

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10 November 2019

Zhang Y

24

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10 November 2019

Aebersold R

25

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10 November 2019

Sorbi S

27

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10 November 2019

Bruni A

28

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10 November 2019

Fraser P

29

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10 November 2019

language of work or name

English

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publication date

1 September 2000

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10 November 2019

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10 November 2019

volume

407

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10 November 2019

issue

6800

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10 November 2019

page(s)

48-54

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

10 November 2019

cites work

1 reference

7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

7 January 2021

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

7 January 2021

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex

1 reference

7 January 2021

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

1 reference

7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

7 January 2021

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

1 reference

7 January 2021

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

7 January 2021

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

7 January 2021

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

1 reference

7 January 2021

A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

1 reference

7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

7 January 2021

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

1 reference

7 January 2021

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

7 January 2021

Familial Alzheimer's disease

1 reference

7 January 2021

Protein identification by solid phase microextraction-capillary zone electrophoresis-microelectrospray-tandem mass spectrometry.

1 reference

7 January 2021

Presenilin 1 interaction in the brain with a novel member of the Armadillo family

1 reference

7 January 2021

Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin

1 reference

7 January 2021

A full genome scan for late onset Alzheimer's disease.

1 reference

7 January 2021

A genome survey for novel Alzheimer disease risk loci: results at 10-cM resolution.

1 reference

7 January 2021

The glp-1 locus and cellular interactions in early C. elegans embryos

1 reference

7 January 2021

HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling

1 reference

7 January 2021

Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling

1 reference

7 January 2021

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

7 January 2021

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

7 January 2021

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

7 January 2021

Normal and abnormal biology of the beta-amyloid precursor protein

1 reference

7 January 2021

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

1 reference

7 January 2021

Evidence for a physical interaction between presenilin and Notch

1 reference

7 January 2021

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

1 reference

7 January 2021

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

7 January 2021

Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells

1 reference

7 January 2021

Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.

1 reference

7 January 2021

Calpain inhibitor I increases beta-amyloid peptide production by inhibiting the degradation of the substrate of gamma-secretase. Evidence that substrate availability limits beta-amyloid peptide production

1 reference

7 January 2021

Identifiers

DOI

10.1038/35024009

2 references

Consolidated OpenCitations Corpus – April 2017

89026

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10993067%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

10 November 2019

1028278722

0 references

89026

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

89026

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10993067%20AND%20SRC:MED&resulttype=core&format=json