Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein (Q28260479)

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P Saftig

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K Craessaerts

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H Vanderstichele

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G Guhde

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W Annaert

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K Von Figura

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F Van Leuven

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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language of work or name

English

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publication date

22 January 1998

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published in

Nature

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volume

391

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page(s)

387-90

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issue

6665

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cites work

1 reference

7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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7 January 2021

Amyloid, the presenilins and Alzheimer's disease

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7 January 2021

Presenilins: genes for life and death

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7 January 2021

Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide

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7 January 2021

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

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7 January 2021

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

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7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

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7 January 2021

Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

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7 January 2021

Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons.

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7 January 2021

Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D.

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7 January 2021

Amyloid beta-peptide is produced by cultured cells during normal metabolism

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7 January 2021

Novel beta-secretase cleavage of beta-amyloid precursor protein in the endoplasmic reticulum/intermediate compartment of NT2N cells

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7 January 2021

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

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7 January 2021

The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities

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7 January 2021

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

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7 January 2021

Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein

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7 January 2021

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

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7 January 2021

Protein topology of presenilin 1

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7 January 2021

Membrane topology of the C. elegans SEL-12 presenilin

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7 January 2021

Evidence for a six-transmembrane domain structure of presenilin 1.

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7 January 2021

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

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7 January 2021

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

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7 January 2021

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing.

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7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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7 January 2021

Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid beta peptides: their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiop

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7 January 2021

Basolateral secretion of amyloid precursor protein in Madin-Darby canine kidney cells is disturbed by alterations of intracellular pH and by introducing a mutation associated with familial Alzheimer's disease

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7 January 2021

Identifiers

DOI

10.1038/34910

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

88846

1053079917

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88846

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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