Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras (Q24290369)

HRas proto-oncogene, GTPase

GOA release 2020-03-11

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GOA release 2020-03-11

enzyme binding

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GOA release 2020-03-11

author name string

C Song

1

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C D Hu

2

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M Masago

3

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K Kariyai

4

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Y Yamawaki-Kataoka

5

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M Shibatohge

6

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D Wu

7

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T Satoh

8

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T Kataoka

Journal of Biological Chemistry

9

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language of work or name

English

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publication date

26 January 2001

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published in

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volume

276

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issue

4

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page(s)

2752-7

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cites work

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

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Multiple Ras functions can contribute to mammalian cell transformation

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The effector interactions of p21ras

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The ins and outs of Raf kinases

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cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

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PIP2 and PIP3: complex roles at the cell surface

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Identification of Ce-AF-6, a novel Caenorhabditis elegans protein, as a putative Ras effector.

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The complexity of Raf-1 regulation

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The synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphate

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Signal transduction from multiple Ras effectors

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A novel family of Ras-binding domains.

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Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

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Receptor and protein kinase C-mediated regulation of ARF binding to the Golgi complex.

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The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

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Three-dimensional structure of the Ras-interacting domain of RalGDS

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Colocalization of Ras and Ral on the membrane is required for Ras-dependent Ral activation through Ral GDP dissociation stimulator

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7 January 2021

Plasma membrane recruitment of RalGDS is critical for Ras-dependent Ral activation

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Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer

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Association of the Ras-antagonistic Rap1/Krev-1 proteins with the Golgi complex

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Cysteine-rich region of Raf-1 interacts with activator domain of post-translationally modified Ha-Ras

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Differential structural requirements for interaction of Ras protein with its distinct downstream effectors.

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Identification of AF-6 and canoe as putative targets for Ras.

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A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation

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Coassociation of Rap1A and Ha-Ras with Raf-1 N-terminal region interferes with ras-dependent activation of Raf-1

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Regulation of phosphoinositide-specific phospholipase C isozymes

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Identification of PLC210, a Caenorhabditis elegans phospholipase C, as a putative effector of Ras.

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Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion

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The small GTPase, Rap1, mediates CD31-induced integrin adhesion

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7 January 2021

Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling

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7 January 2021

All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral.

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Inhibition of serum- and ras-stimulated DNA synthesis by antibodies to phospholipase C.

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ras-transformed cells: altered levels of phosphatidylinositol-4,5-bisphosphate and catabolites

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The effect of posttranslational modifications on the interaction of Ras2 with adenylyl cyclase

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7 January 2021

Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation

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7 January 2021

Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase

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7 January 2021