Epoxide hydrolases: biochemistry and molecular biology (Q24290733)

Europe PubMed Central

title

Epoxide hydrolases: biochemistry and molecular biology (English)

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main subject

biochemistry

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Leukotriene A4 hydrolase

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epoxide hydrolase activity

GOA release 2020-03-11

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Chemico-biological Interactions

GOA release 2020-03-11

molecular biology

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author name string

A J Fretland

series ordinal

1

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C J Omiecinski

series ordinal

2

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language of work or name

English

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publication date

1 December 2000

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published in

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volume

129

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issue

1-2

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page(s)

41-59

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cites work

Properties of liver microsomal cholesterol 5,6-oxide hydrolase.

1 reference

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Increased cholesterol epoxide hydrolase activity in clofibrate-fed animals

7 January 2021

1 reference

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Distinct rat hepatic microsomal epoxide hydrolases catalyze the hydration of cholesterol 5,6 alpha-oxide and certain xenobiotic alkene and arene oxides

7 January 2021

1 reference

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Visualization of a covalent intermediate between microsomal epoxide hydrolase, but not cholesterol epoxide hydrolase, and their substrates

7 January 2021

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Cholesterol epoxide is a direct-acting mutagen

7 January 2021

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The cytotoxic and mutagenic properties of cholesterol oxidation products

7 January 2021

1 reference

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Mouse liver microsomal cholesterol epoxide hydrolase: a specific inhibition of its activity by 5,6 alpha-Imino-5 alpha-cholestan-3 alpha-OL.

7 January 2021

1 reference

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Hepoxilins: a review on their cellular actions

7 January 2021

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Hepoxilin A3 (HxA3) is formed by the rat aorta and is metabolized into HxA3-C, a glutathione conjugate

7 January 2021

1 reference

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Hepoxilin signaling in intact human neutrophils: biphasic elevation of intracellular calcium by unesterified hepoxilin A3

7 January 2021

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Hepoxilin A3 is the endogenous lipid mediator opposing hypotonic swelling of intact human platelets

7 January 2021

1 reference

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Cloning and characterization of the human leukotriene A4 hydrolase gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

The human leukotriene A4 hydrolase gene is expressed in two alternatively spliced mRNA forms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Isolation of human promoter regions by Alu repeat consensus-based polymerase chain reaction.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Regulation of leukotriene A4 hydrolase activity in endothelial cells by phosphorylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Structure, function, and regulation of leukotriene A4 hydrolase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Zinc and other divalent cations inhibit purified leukotriene A4 hydrolase and leukotriene B4 biosynthesis in human polymorphonuclear leukocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Development of selective tight-binding inhibitors of leukotriene A4 hydrolase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Mouse leukotriene A4 hydrolase is expressed at high levels in intestinal crypt cells and splenic lymphocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Evidence for a catalytic role of tyrosine 383 in the peptidase reaction of leukotriene A4 hydrolase

7 January 2021

1 reference

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Evidence for a carbocation intermediate in the enzymatic transformation of leukotriene A4 into leukotriene B4

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Gene evolution of epoxide hydrolases and recommended nomenclature

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Cytosolic epoxide hydrolase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Purification and characterization of rat-liver cytosolic epoxide hydrolase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Human liver cytosolic epoxide hydrolases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

cDNA cloning and expression of a soluble epoxide hydrolase from human liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Distribution and inducibility of cytosolic epoxide hydrolase in male Sprague-Dawley rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

An impaired peroxisomal targeting sequence leading to an unusual bicompartmental distribution of cytosolic epoxide hydrolase.

7 January 2021

1 reference

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Studies on the intracellular distributions of soluble epoxide hydrolase and of catalase by digitonin-permeabilization of hepatocytes isolated from control and clofibrate-treated mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Structural characterization of the human soluble epoxide hydrolase gene (EPHX2).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Cloning and expression of soluble epoxide hydrolase from potato

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Identification and functional characterization of human soluble epoxide hydrolase genetic polymorphisms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Tissue specific basal expression of soluble murine epoxide hydrolase and effects of clofibrate on the mRNA levels in extrahepatic tissues and liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Induction of cytosolic and microsomal epoxide hydrolases and proliferation of peroxisomes and mitochondria in mouse liver after dietary exposure to p-chlorophenoxyacetic acid, 2,4-dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acid

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Induction of cytosolic and microsomal epoxide hydrolases in mouse liver by peroxisome proliferators, with special emphasis on structural analogues of 2-ethylhexanoic acid

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Proliferation of peroxisomes and induction of cytosolic and microsomal epoxide hydrolases in different strains of mice and rats after dietary treatment with clofibrate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Rat cytosolic epoxide hydrolase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Improved radiolabeled substrates for soluble epoxide hydrolase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Spectrophotometric substrates for cytosolic epoxide hydrolase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Characterization of the cytosolic epoxide hydrolase-catalyzed hydration products from 9,10:12,13-diepoxy stearic esters

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Inhibition of epoxide hydrolases and glutathione S-transferases by 2-, 3-, and 4-substituted derivatives of 4'-phenylchalcone and its oxide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Inhibition of cytosolic epoxide hydrolase by trans-3-phenylglycidols

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Inhibition of epoxide hydrolase from human, monkey, bovine, rabbit and murine liver by trans-3-phenylglycidols

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Potent urea and carbamate inhibitors of soluble epoxide hydrolases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Inhibition of soluble and microsomal epoxide hydrolase by zinc and other metals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Cytochrome P450 2C is an EDHF synthase in coronary arteries

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

EDHF: a cytochrome P450 metabolite in coronary arteries

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Molecular and biochemical evidence for the involvement of the Asp-333-His-523 pair in the catalytic mechanism of soluble epoxide hydrolase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Mechanism of soluble epoxide hydrolase. Formation of an alpha-hydroxy ester-enzyme intermediate through Asp-333.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Asp333, Asp495, and His523 form the catalytic triad of rat soluble epoxide hydrolase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Detoxification of environmental mutagens and carcinogens: structure, mechanism, and evolution of liver epoxide hydrolase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Stereoselective epoxidation and hydration at the K-region of polycyclic aromatic hydrocarbons by cDNA-expressed cytochromes P450 1A1, 1A2, and epoxide hydrolase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Human peripheral lymphocytes as indicators of microsomal epoxide hydrolase activity in liver and lung

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Purification and initial characterization of microsomal epoxide hydrolase from the human adrenal gland

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Rabbit microsomal epoxide hydrolase: isolation and characterization of the xenobiotic metabolizing enzyme cDNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Microsomal epoxide hydrolase of rat liver. Purification and characterization of enzyme fractions with different chromatographic characteristics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

The human microsomal epoxide hydrolase gene (EPHX1): complete nucleotide sequence and structural characterization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Xenobiotic microsomal epoxide hydrolase: 5' sequence of the human gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Effects of chemical inducers on human microsomal epoxide hydrolase in primary hepatocyte cultures

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Induction of liver microsomal epoxide hydrolase, UDP-glucuronyl transferase and cytosolic glutathione transferase in different rodent species by 2-acetylaminofluorene or 3-methylcholanthrene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Differential induction of rat hepatic microsomal epoxide hydrolase and rGSTA2 by diazines: the role of cytochrome P450 2E1-mediated metabolic activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Induction of microsomal epoxide hydrolase by nitrosamines in rat liver. Effect on messenger ribonucleic acids

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Induction of rat liver microsomal cytochrome P-450 isozymes and epoxide hydrolase by a series of 4'-substituted-2,3,4,5-tetrachlorobiphenyls

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Glucocorticoid repression and basal regulation of the epoxide hydrolase promoter

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions

7 January 2021

2 references

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

7 January 2021

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

inferred from DOI database lookup

7 January 2021

based on heuristic

Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Post-transcriptional regulation of human microsomal epoxide hydrolase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Human hepatic microsomal epoxide hydrolase: comparative analysis of polymorphic expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Human microsomal epoxide hydrolase: 5'-flanking region genetic polymorphisms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Comparison of blood concentrations of 1,3-butadiene and butadiene epoxides in mice and rats exposed to 1,3-butadiene by inhalation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Oxidation of butadiene monoxide to meso- and (+/-)-diepoxybutane by cDNA-expressed human cytochrome P450s and by mouse, rat, and human liver microsomes: evidence for preferential hydration of meso-diepoxybutane in rat and human liver microsomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Benzene metabolism by reconstituted cytochromes P450 2B1 and 2E1 and its modulation by cytochrome b5, microsomal epoxide hydrolase, and glutathione transferases: evidence for an important role of microsomal epoxide hydrolase in the formation of hydr

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Measurement of benzene oxide in the blood of rats following administration of benzene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Activation and detoxication of aflatoxin B1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Kinetics of hydrolysis and reaction of aflatoxin B1 exo-8,9-epoxide and relevance to toxicity and detoxication

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Activation of benzo[a]pyrene and aflatoxin B1 to mutagenic chemical species by microsomal preparations from rat liver and small intestine in relation to microsomal epoxide hydrolase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Genotoxicity characteristics of reverse diol-epoxides of chrysene.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Mutagenicity of oxidized microsomal metabolites of 1-nitropyrene in Chinese hamster ovary cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Further metabolism of diol-epoxides of chrysene and dibenz[a,c]anthracene to DNA binding species as evidenced by 32P-postlabelling analysis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Kinetics and stereochemistry of the microsomal epoxide hydrolase-catalyzed hydrolysis of cis-stilbene oxides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Purification of microsomal epoxide hydrolase from liver of rhesus monkey: partial separation of cis- and trans-stilbene oxide hydrolase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Metabolism of styrene oxide to styrene glycol by mouse liver and lung.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Pneumotoxicity and hepatotoxicity of styrene and styrene oxide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Recombinant expression of human microsomal epoxide hydrolase protects V79 Chinese hamster cells from styrene oxide- but not from ethylene oxide-induced DNA strand breaks.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Phenytoin embryopathy: effect of epoxide hydrolase inhibitor on phenytoin exposure in utero in C57BL/6J mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

An in vitro study of the microsomal metabolism and cellular toxicity of phenytoin, sorbinil and mianserin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

The metabolism of carbamazepine in humans: steric course of the enzymatic hydrolysis of the 10,11-epoxide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Heterologous expression of human microsomal epoxide hydrolase in Saccharomyces cerevisiae. Study of the valpromide-carbamazepine epoxide interaction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Endogenous Role of Microsomal Epoxide Hydrolase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Subcellular distribution, catalytic properties and partial purification of epoxide hydrolase in the human adrenal gland

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Cyclopropyl oxiranes: reversible inhibitors of cytosolic and microsomal epoxide hydrolases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Symposium overview: the role of genetic polymorphism and repair deficiencies in environmental disease.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Association of CYP1A1 and microsomal epoxide hydrolase polymorphisms with lung squamous cell carcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Microsomal epoxide hydrolase gene polymorphism and susceptibility to colon cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Mechanism of microsomal epoxide hydrolase. Semifunctional site-specific mutants affecting the alkylation half-reaction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Microsomal and soluble epoxide hydrolases are members of the same family of C-X bond hydrolase enzymes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Structure of Aspergillus niger epoxide hydrolase at 1.8 A resolution: implications for the structure and function of the mammalian microsomal class of epoxide hydrolases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

Differences in Phenytoin Biotransformation and Susceptibility to Congenital Malformations: A Review

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900197-6

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0009-2797(00)00197-6

1 reference

Consolidated OpenCitations Corpus – April 2017

release_cdcyhobzbjhnvfjbjxvc6dw5ge

1703992

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/cdcyhobzbjhnvfjbjxvc6dw5ge

mapped directly with Wikidata item

24 November 2022

based on heuristic

1703992

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference