Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation (Q24291515)

negative regulation of cytokine production

GOA release 2020-03-11

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GOA release 2020-03-11

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L A Schubert

1

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E Jeffery

2

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Y Zhang

3

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F Ramsdell

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S F Ziegler

Journal of Biological Chemistry

5

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language of work or name

English

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publication date

5 October 2001

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published in

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volume

276

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page(s)

37672-9

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issue

40

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cites work

The scurfy mouse mutant has previously unrecognized hematological abnormalities and resembles Wiskott-Aldrich syndrome

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Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic education

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The mouse homolog of the Wiskott-Aldrich syndrome protein (WASP) gene is highly conserved and maps near the scurfy (sf) mutation on the X chromosome

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Disease in the scurfy (sf) mouse is associated with overexpression of cytokine genes

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Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

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Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells

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CTLA-4 can function as a negative regulator of T cell activation

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Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

21 January 2018

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JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome

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X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

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The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

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Five years on the wings of fork head

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DNA-binding properties and secondary structural model of the hepatocyte nuclear factor 3/fork head domain

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Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells

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The human gp39 promoter. Two distinct nuclear factors of activated T cell protein-binding elements contribute independently to transcriptional activation.

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The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB

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FREAC-1 contains a cell-type-specific transcriptional activation domain and is expressed in epithelial-mesenchymal interfaces

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Negative regulation of the forkhead transcription factor FKHR by Akt.

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The whn transcription factor encoded by the nude locus contains an evolutionarily conserved and functionally indispensable activation domain

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Transcription factors of the NFAT family: regulation and function

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Novel NFAT sites that mediate activation of the interleukin-2 promoter in response to T-cell receptor stimulation

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Tumor necrosis factor alpha gene regulation in activated T cells involves ATF-2/Jun and NFATp

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Human granulocyte-macrophage colony-stimulating factor enhancer function is associated with cooperative interactions between AP-1 and NFATp/c

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The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino-acid residues adjacent to the recognition helix

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Structural changes in the region directly adjacent to the DNA-binding helix highlight a possible mechanism to explain the observed changes in the sequence-specific binding of winged helix proteins

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Dynamic DNA contacts observed in the NMR structure of winged helix protein-DNA complex

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Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors

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Role of the forkhead transcription family member, FKHR, in thymocyte differentiation.

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Molecular cloning of FKHRL1P2, a member of the developmentally regulated fork head domain transcription factor family

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Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23)

21 January 2018

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Role of transcriptional repressor ICER in cyclic AMP-mediated attenuation of cytokine gene expression in human thymocytes

21 January 2018

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Genesis, a winged helix transcriptional repressor with expression restricted to embryonic stem cells

21 January 2018

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Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending

21 January 2018

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7 January 2021

Suppression of T cell function: a potential role for transcriptional repressor ICER.

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7 January 2021

The thyroid transcription factor 2 (TTF-2) is a promoter-specific DNA-binding independent transcriptional repressor

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7 January 2021

The mouse scurfy (sf) mutation is tightly linked to Gata1 and Tfe3 on the proximal X chromosome

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7 January 2021

Redox properties of cytochrome c nitrite reductase from Desulfovibrio desulfuricans ATCC 27774

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7 January 2021