Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells (Q46091258)

19 December 2017

title

Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells (English)

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19 December 2017

author name string

C A Chambers

series ordinal

1

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19 December 2017

T J Sullivan

series ordinal

2

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19 December 2017

J P Allison

series ordinal

3

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19 December 2017

language of work or name

English

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publication date

1 December 1997

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19 December 2017

published in

Immunity

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19 December 2017

volume

7

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19 December 2017

issue

6

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19 December 2017

page(s)

885-895

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19 December 2017

CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes

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B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation

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7 January 2021

A new member of the immunoglobulin superfamily--CTLA-4

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Interactions between the amino-terminal domain of p56lck and cytoplasmic domains of CD4 and CD8 alpha in yeast

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Co-stimulation in T cell responses.

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Thymocyte development is normal in CTLA-4-deficient mice

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7 January 2021

The role of CTLA-4 in the regulation and initiation of T-cell responses

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7 January 2021

B7-1-dependent co-stimulation results in qualitatively and quantitatively different responses by CD4+ and CD8+ T cells

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Treatment of murine lupus with CTLA4Ig

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T cell-mediated elimination of B7.2 transgenic B cells

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7 January 2021

CD28-B7 interactions allow the induction of CD8+ cytotoxic T lymphocytes in the absence of exogenous help.

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CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

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Specific blockade of CTLA-4/B7 interactions results in exacerbated clinical and histologic disease in an actively-induced model of experimental allergic encephalomyelitis.

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Signals and signs for lymphocyte responses

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CTLA-4: a negative regulator of autoimmune disease.

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7 January 2021

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation

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7 January 2021

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells

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7 January 2021

Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo

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Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer

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B cell function in mice transgenic for mCTLA4-H gamma 1: lack of germinal centers correlated with poor affinity maturation and class switching despite normal priming of CD4+ T cells

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Enhancement of antitumor immunity by CTLA-4 blockade

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7 January 2021

CD28/B7 system of T cell costimulation

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Cytotoxic T lymphocyte-associated molecule-4, a high-avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail

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7 January 2021

Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement

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7 January 2021

The role of the CD28 receptor during T cell responses to antigen

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7 January 2021

Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule

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7 January 2021

Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site

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7 January 2021

The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands

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7 January 2021

Distinct involvement of CD45 in antigen receptor signalling in CD4+ and CD8+ primary T cells

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7 January 2021

Evidence for differential intracellular signaling via CD4 and CD8 molecules

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7 January 2021

Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2

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7 January 2021

Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

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7 January 2021

Lymphocyte life-span and memory

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7 January 2021

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

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7 January 2021

Differential requirements for survival and proliferation of CD8 naïve or memory T cells

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7 January 2021

The emerging role of CTLA-4 as an immune attenuator

1 reference

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7 January 2021

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

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7 January 2021

Turnover of naive- and memory-phenotype T cells

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7 January 2021

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

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7 January 2021

Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways

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7 January 2021

Endogenous altered peptide ligands can affect peripheral T cell responses

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7 January 2021

CTLA-4 ligation blocks CD28-dependent T cell activation

1 reference

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7 January 2021

CTLA-4 can function as a negative regulator of T cell activation

1 reference

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7 January 2021

CTLA-4, a negative regulator of T-lymphocyte activation

1 reference

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7 January 2021

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

1 reference

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7 January 2021

Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein

1 reference

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7 January 2021

10.1016/S1074-7613(00)80406-9

Identifiers

DOI

1 reference

19 December 2017

PubMed ID

9430233

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19 December 2017