The androgen receptor induces integrin α6β1 to promote prostate tumor cell survival via NF-κB and Bcl-xL Independently of PI3K signaling (Q24292881)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6878780&resulttype=core&format=json

13 May 2020

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integrin subunit beta 1

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Integrin subunit beta 4

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integrin subunit alpha 3

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RELA proto-oncogene, NF-kB subunit

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integrin subunit alpha 6

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integrin subunit alpha 2

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integrin subunit alpha V

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negative regulation of extrinsic apoptotic signaling pathway

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Laura E Lamb

1

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13 May 2020

Jelani C Zarif

series ordinal

2

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13 May 2020

Cindy K Miranti

series ordinal

3

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13 May 2020

language of work or name

English

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publication date

1 April 2011

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published in

Cancer Research

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13 May 2020

volume

71

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13 May 2020

page(s)

2739-2749

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13 May 2020

issue

7

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Identification of the human alpha6 integrin gene promoter

13 May 2020

cites work

1 reference

12 December 2020

Clinging to life: cell to matrix adhesion and cell survival

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12 December 2020

Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer

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12 December 2020

Androgen receptor signaling is required for androgen-sensitive human prostate cancer cell proliferation and survival

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12 December 2020

The alpha 6 beta 1 and alpha 6 beta 4 integrins in human prostate cancer progression.

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12 December 2020

Integrative microarray analysis of pathways dysregulated in metastatic prostate cancer

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12 December 2020

Expression profile of an androgen regulated prostate specific homeobox gene NKX3.1 in primary prostate cancer

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12 December 2020

Androgen receptor-dependent regulation of Bcl-xL expression: Implication in prostate cancer progression

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12 December 2020

The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L).

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12 December 2020

Long-term androgen-ablation causes increased resistance to PI3K/Akt pathway inhibition in prostate cancer cells

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12 December 2020

Expression of NF-?B in prostate cancer lymph node metastases

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12 December 2020

NF-kappa B activates prostate-specific antigen expression and is upregulated in androgen-independent prostate cancer

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12 December 2020

Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol

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12 December 2020

Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer

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12 December 2020

The impact of cell adhesion changes on proliferation and survival during prostate cancer development and progression

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12 December 2020

Molecular determinants of resistance to antiandrogen therapy

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12 December 2020

Mechanisms of prostate cancer cell survival after inhibition of AR expression

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12 December 2020

Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia.

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12 December 2020

Complete loss of PTEN expression as a possible early prognostic marker for prostate cancer metastasis

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12 December 2020

Progression of prostate cancer by synergy of AKT with genotropic and nongenotropic actions of the androgen receptor

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12 December 2020

Small-interfering RNA-induced androgen receptor silencing leads to apoptotic cell death in prostate cancer

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12 December 2020

Interleukin 6, a nuclear factor-kappaB target, predicts resistance to docetaxel in hormone-independent prostate cancer and nuclear factor-kappaB inhibition by PS-1145 enhances docetaxel antitumor activity.

1 reference

12 December 2020

6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF- B-dependent resistance to apoptosis in 3D mammary acini

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12 December 2020

Differential expression of alpha 6 and alpha 2 very late antigen integrins in the normal, hyperplastic, and neoplastic prostate: simultaneous demonstration of cell surface receptors and their extracellular ligands

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12 December 2020

Integrins: bidirectional, allosteric signaling machines

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12 December 2020

The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists

1 reference

12 December 2020

Androgen-dependent cell cycle arrest and apoptotic death in PC-3 prostatic cell cultures expressing a full-length human androgen receptor

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12 December 2020

Nuclear Localization of Nuclear Factor- B p65 in Primary Prostate Tumors Is Highly Predictive of Pelvic Lymph Node Metastases

1 reference

12 December 2020

E-cadherin-mediated survival of androgen-receptor-expressing secretory prostate epithelial cells derived from a stratified in vitro differentiation model

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12 December 2020

Inhibition of integrin-mediated crosstalk with epidermal growth factor receptor/Erk or Src signaling pathways in autophagic prostate epithelial cells induces caspase-independent death

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12 December 2020

Application of cell adhesion to study signaling networks

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12 December 2020

Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state

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12 December 2020

Identification and characterization of nuclear factor kappaB binding sites in the murine bcl-x promoter.

1 reference

12 December 2020

Antiapoptotic signaling in LNCaP prostate cancer cells: a survival signaling pathway independent of phosphatidylinositol 3'-kinase and Akt/protein kinase B.

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12 December 2020

Androgen receptor expression in prostate carcinoma cells suppresses alpha6beta4 integrin-mediated invasive phenotype

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12 December 2020

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

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12 December 2020

The life of a cell: apoptosis regulation by the PI3K/PKB pathway

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12 December 2020

Prostate cancer cells tolerate a narrow range of androgen receptor expression and activity

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12 December 2020

Androgen induction of in vitro prostate cell differentiation.

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12 December 2020

Sensing the environment: a historical perspective on integrin signal transduction

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12 December 2020

Antagonism between PTEN/MMAC1/TEP-1 and androgen receptor in growth and apoptosis of prostatic cancer cells

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12 December 2020

Differential expression of integrin subunits in DU-145/AR prostate cancer cells

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12 December 2020

The nuclear factor-kappaB pathway controls the progression of prostate cancer to androgen-independent growth.

1 reference

12 December 2020

Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers

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12 December 2020

Bcl-xL is overexpressed in hormone-resistant prostate cancer and promotes survival of LNCaP cells via interaction with proapoptotic Bak.

1 reference

12 December 2020

Evaluation of the expression of integrins and cell adhesion molecules through tissue microarray in lymph node metastases of prostate cancer.

1 reference

12 December 2020

Androgen modulation of adhesion and antiadhesion molecules in PC-3 prostate cancer cells expressing androgen receptor

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12 December 2020

Leukemia inhibitory factor promotes human first trimester extravillous trophoblast adhesion to extracellular matrix and secretion of tissue inhibitor of metalloproteinases-1 and -2

1 reference

12 December 2020

Derivation of androgen-independent human LNCaP prostatic cancer cell sublines: role of bone stromal cells

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12 December 2020

Chromosomal deletions and tumor suppressor genes in prostate cancer.

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12 December 2020

Identification of regulatory elements of human alpha 6 integrin subunit gene

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12 December 2020

10.1158/0008-5472.CAN-10-2745

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

266633

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6878780&resulttype=core&format=json

13 May 2020

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Consolidated OpenCitations Corpus – April 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6878780&resulttype=core&format=json

13 May 2020

2 references

Consolidated OpenCitations Corpus – April 2017

266633