integrin subunit alpha V (Q21107757)

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mammalian protein found in Homo sapiens
  • ITGAV
  • antigen identified by monoclonal antibody L230
  • integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
  • vitronectin receptor subunit alpha
  • integrin alphaVbeta3
  • integrin alpha-V
edit
Language Label Description Also known as
English
integrin subunit alpha V
mammalian protein found in Homo sapiens
  • ITGAV
  • antigen identified by monoclonal antibody L230
  • integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
  • vitronectin receptor subunit alpha
  • integrin alphaVbeta3
  • integrin alpha-V

Statements

molecular function
protein binding
determination method
IPI
17 references
retrieved
9 May 2019
stated in
ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IPI
retrieved
9 May 2019
stated in
CCN3 (NOV) Is a Novel Angiogenic Regulator of the CCN Protein Family
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IPI
retrieved
9 May 2019
stated in
alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IPI
retrieved
9 May 2019
stated in
Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IPI
retrieved
9 May 2019
stated in
Identification of novel integrin binding partners for calcium and integrin binding protein 1 (CIB1): structural and thermodynamic basis of CIB1 promiscuity
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IPI
retrieved
9 May 2019
stated in
Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IPI
retrieved
9 May 2019
stated in
Integrin-dependent functions of the angiogenic inducer NOV (CCN3): implication in wound healing
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IPI
retrieved
9 May 2019
stated in
Basic amino-acid side chains regulate transmembrane integrin signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IPI
retrieved
9 May 2019
stated in
Structural determinants of integrin β-subunit specificity for latent TGF-β.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IPI
retrieved
9 May 2019
stated in
Latent TGF-β structure and activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IPI
retrieved
9 May 2019
stated in
A novel adaptation of the integrin PSI domain revealed from its crystal structure
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IPI
retrieved
9 May 2019
stated in
Lung cancer cell migration is regulated via repressing growth factor PTN/RPTP β/ζ signaling by menin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IPI
retrieved
9 May 2019
stated in
Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IPI
retrieved
9 May 2019
stated in
Crystal structure of the extracellular segment of integrin alpha Vbeta3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IPI
retrieved
9 May 2019
stated in
Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IPI
retrieved
9 May 2019
stated in
Murine lipid phosphate phosphohydrolase-3 acts as a cell-associated integrin ligand
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IPI
retrieved
9 May 2019
stated in
Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IPI
cell component
integrin alphav-beta3 complex
determination method
IDA
5 references
retrieved
9 May 2019
stated in
Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectin
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
9 May 2019
stated in
Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
9 May 2019
stated in
KSHV attachment and entry are dependent on αVβ3 integrin localized to specific cell surface microdomains and do not correlate with the presence of heparan sulfate
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
9 May 2019
stated in
Apolipoprotein(a) acts as a chemorepellent to human vascular smooth muscle cells via integrin αVβ3 and RhoA/ROCK-mediated mechanisms
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
9 May 2019
stated in
HMGB1 inhibits macrophage activity in efferocytosis through binding to the alphavbeta3-integrin
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IDA
cell surface
determination method
IDA
ISS
11 references
retrieved
17 October 2017
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06756&geneProductId=UniProtKB:P06756
determination method
ISS
retrieved
17 October 2017
stated in
Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06756&geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
17 October 2017
stated in
Quantitative proteomics identifies a Dab2/integrin module regulating cell migration
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06756&geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
17 October 2017
stated in
Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06756&geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
17 October 2017
stated in
Characterization of integrin engagement during defined human embryonic stem cell culture
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06756&geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
17 October 2017
stated in
KSHV attachment and entry are dependent on αVβ3 integrin localized to specific cell surface microdomains and do not correlate with the presence of heparan sulfate
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06756&geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
17 October 2017
stated in
Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06756&geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
17 October 2017
stated in
Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06756&geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
17 October 2017
stated in
Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06756&geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
17 October 2017
stated in
Cloning and expression of a divergent integrin subunit beta 8
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06756&geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
17 October 2017
stated in
The androgen receptor induces integrin α6β1 to promote prostate tumor cell survival via NF-κB and Bcl-xL Independently of PI3K signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06756&geneProductId=UniProtKB:P06756
determination method
IDA
focal adhesion
determination method
IDA
IEA
5 references
retrieved
17 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06756&geneProductId=UniProtKB:P06756
determination method
IEA
retrieved
17 October 2017
stated in
alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06756&geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
17 October 2017
stated in
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06756&geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
17 October 2017
stated in
KSHV attachment and entry are dependent on αVβ3 integrin localized to specific cell surface microdomains and do not correlate with the presence of heparan sulfate
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06756&geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
17 October 2017
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06756&geneProductId=UniProtKB:P06756
determination method
IDA
focal adhesion
determination method
HDA
IDA
IEA
6 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IEA
retrieved
9 May 2019
stated in
alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
9 May 2019
stated in
KSHV attachment and entry are dependent on αVβ3 integrin localized to specific cell surface microdomains and do not correlate with the presence of heparan sulfate
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
9 May 2019
stated in
The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
9 May 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
9 May 2019
stated in
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
HDA
cell surface
determination method
HDA
IDA
ISS
11 references
retrieved
9 May 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
ISS
retrieved
9 May 2019
stated in
Cloning and expression of a divergent integrin subunit beta 8
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
9 May 2019
stated in
Characterization of integrin engagement during defined human embryonic stem cell culture
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
9 May 2019
stated in
Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
9 May 2019
stated in
KSHV attachment and entry are dependent on αVβ3 integrin localized to specific cell surface microdomains and do not correlate with the presence of heparan sulfate
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
9 May 2019
stated in
Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
9 May 2019
stated in
Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
9 May 2019
stated in
Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
9 May 2019
stated in
The androgen receptor induces integrin α6β1 to promote prostate tumor cell survival via NF-κB and Bcl-xL Independently of PI3K signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
IDA
retrieved
9 May 2019
stated in
Quantitative proteomics identifies a Dab2/integrin module regulating cell migration
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
HDA
retrieved
9 May 2019
stated in
Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance
GOA
curator
UniProt
UniProt protein ID
P06756
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06756
determination method
HDA
biological process

Identifiers

MeSH descriptor ID
D039564
subject named as
Integrin alphaV
0 references
Freebase ID
/m/03ct04s
0 references
Microsoft Academic ID
2778816404
0 references
2781238382
0 references
PDB structure ID
 
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