BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair (Q24293244)

GOA release 2020-03-11

BLM RecQ like helicase

1 reference

GOA release 2020-03-11

DNA helicase activity

1 reference

GOA release 2020-03-11

author name string

Amitabh V Nimonkar

1

0 references

Jochen Genschel

2

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Eri Kinoshita

3

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Piotr Polaczek

4

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Judith L Campbell

5

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Claire Wyman

6

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Paul Modrich

7

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Stephen C Kowalczykowski

describes a project that uses

8

0 references

language of work or name

English

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publication date

15 February 2011

0 references

published in

Genes & Development

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volume

25

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issue

4

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page(s)

350-62

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ImageQuant

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3042158/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Human CtIP promotes DNA end resection

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Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity

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The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities

19 March 2017

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The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

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Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

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The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance

19 March 2017

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Identification of a human gene encoding a homologue of Saccharomyces cerevisiae EXO1, an exonuclease implicated in mismatch repair and recombination

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19 March 2017

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19 March 2017

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Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends

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Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2

27 September 2017

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Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding

27 September 2017

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Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATM

27 September 2017

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The full-length Saccharomyces cerevisiae Sgs1 protein is a vigorous DNA helicase that preferentially unwinds holliday junctions

27 September 2017

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27 September 2017

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Interplay of Mre11 nuclease with Dna2 plus Sgs1 in Rad51-dependent recombinational repair

27 September 2017

1 reference

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Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042158

Identification of the Xenopus DNA2 protein as a major nuclease for the 5'->3' strand-specific processing of DNA ends

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042158

Processing of G4 DNA by Dna2 helicase/nuclease and replication protein A (RPA) provides insights into the mechanism of Dna2/RPA substrate recognition

27 September 2017

1 reference

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Novel pro- and anti-recombination activities of the Bloom's syndrome helicase

27 September 2017

1 reference

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DNA double-strand break repair: all's well that ends well

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042158

The Mre11 nuclease is not required for 5' to 3' resection at multiple HO-induced double-strand breaks

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042158

The human Bloom syndrome gene suppresses the DNA replication and repair defects of yeast dna2 mutants

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042158

RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042158

Biochemical characterization of the DNA helicase activity of the escherichia coli RecQ helicase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042158

Homology search and choice of homologous partner during mitotic recombination

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042158

RecQ helicase, in concert with RecA and SSB proteins, initiates and disrupts DNA recombination

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042158

Chi recombination activity in phage lambda decays as a function of genetic distance

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042158

Identification and purification of a single-stranded-DNA-specific exonuclease encoded by the recJ gene of Escherichia coli

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042158

Intermediates of recombination during mating type switching in Saccharomyces cerevisiae

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042158

Mre11-Rad50-Xrs2 and Sae2 promote 5' strand resection of DNA double-strand breaks

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042158

Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042158

Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042158

DNA helicases Sgs1 and BLM promote DNA double-strand break resection

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042158

The nuclease activity of the yeast DNA2 protein, which is related to the RecB-like nucleases, is essential in vivo

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042158

Bloom syndrome: a mendelian prototype of somatic mutational disease.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042158

A DNA exonuclease induced during meiosis of Schizosaccharomyces pombe.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042158

The P. furiosus mre11/rad50 complex promotes 5' strand resection at a DNA double-strand break

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042158

Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042158

29 November 2018

Identifiers

DOI

10.1101/GAD.2003811

1 reference

release_wm3zq6x7yjd5bgumoiya3ffpja

1240933

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/wm3zq6x7yjd5bgumoiya3ffpja

mapped directly with Wikidata item

24 November 2022

based on heuristic

1240933

1 reference

1 reference

1 reference