Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding (Q24294523)

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18 December 2019

title

Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding (English)

1 reference

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18 December 2019

0 references

1 reference

Purinergic receptor P2Y12

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GOA release 2020-03-11

platelet aggregation

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GOA release 2020-03-11

author

Marco Cattaneo

1

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18 December 2019

author name string

Maddalena L Zighetti

2

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18 December 2019

Rossana Lombardi

3

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18 December 2019

Constantino Martinez

4

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18 December 2019

Anna Lecchi

5

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18 December 2019

Pamela B Conley

6

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18 December 2019

Jerry Ware

7

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18 December 2019

Zaverio M Ruggeri

8

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18 December 2019

language of work or name

English

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publication date

10 February 2003

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

18 December 2019

published in

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18 December 2019

volume

100

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18 December 2019

issue

4

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18 December 2019

page(s)

1978-1983

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Identification of the platelet ADP receptor targeted by antithrombotic drugs

18 December 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149944

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149944

A general method for isolation of high molecular weight DNA from eukaryotes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149944

Identification by site-directed mutagenesis of residues involved in ligand recognition and activation of the human A3 adenosine receptor

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149944

Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149944

Key role of the P2Y(1) receptor in tissue factor-induced thrombin-dependent acute thromboembolism: studies in P2Y(1)-knockout mice and mice treated with a P2Y(1) antagonist

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149944

Agonist-induced conformational changes at the cytoplasmic side of transmembrane segment 6 in the beta 2 adrenergic receptor mapped by site-selective fluorescent labeling.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149944

ADP receptors and clinical bleeding disorders

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149944

Ticlopidine and clopidogrel

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149944

The role of amino acids in extracellular loops of the human P2Y1 receptor in surface expression and activation processes.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149944

Role of the extracellular loops of G protein-coupled receptors in ligand recognition: a molecular modeling study of the human P2Y1 receptor.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149944

Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149944

Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149944

Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149944

Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149944

An inherited bleeding disorder linked to a defective interaction between ADP and its receptor on platelets. Its influence on glycoprotein IIb-IIIa complex function

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149944

Homologous mutations near the junction of the sixth transmembrane domain and the third extracellular loop lead to constitutive activity and enhanced agonist affinity at all muscarinic receptor subtypes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149944

Identification of a ligand-dependent switch within a muscarinic receptor

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149944

A review of mutagenesis studies of angiotensin II type 1 receptor, the three-dimensional receptor model in search of the agonist and antagonist binding site and the hypothesis of a receptor activation mechanism

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149944

Preparation of suspensions of washed platelets from humans.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149944

Identification of a new congenital defect of platelet function characterized by severe impairment of platelet responses to adenosine diphosphate

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149944

Platelets from a patient heterozygous for the defect of P2CYC receptors for ADP have a secretion defect despite normal thromboxane A2 production and normal granule stores: further evidence that some cases of platelet 'primary secretion defect' are h

30 May 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0437879100

P2y(12), a new platelet ADP receptor, target of clopidogrel

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0437879100

Patients with congenital abnormality of platelet aggregation induced by Ca(2+) ionophores may have a defect of the platelet P2Y(12) receptor for ADP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0437879100

Purinoceptors on blood platelets: further pharmacological and clinical evidence to suggest the presence of two ADP receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0437879100

Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12578987

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Deficiency of (33P)2MeS-ADP binding sites on platelets with secretion defect, normal granule stores and normal thromboxane A2 production. Evidence that ADP potentiates platelet secretion independently of the formation of large platelet aggregates an

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12578987

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Use of a sandwich enzyme-linked immunosorbent assay strategy to study mechanisms of G protein-coupled receptor assembly

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12578987

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0437879100

1 reference

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18 December 2019

0 references

1 reference

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18 December 2019

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