Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge (Q24294601)

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GeneDB

GPI transamidase component GAA1

5 February 2019

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GeneDB

6 February 2019

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Phosphatidylinositol glycan anchor biosynthesis class K

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protein disulfide isomerase activity

GOA release 2020-03-11

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GOA release 2020-03-11

pig

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author name string

Kazuhito Ohishi

1

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Kisaburo Nagamune

2

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Yusuke Maeda

3

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Taroh Kinoshita

Journal of Biological Chemistry

4

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language of work or name

English

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publication date

18 April 2003

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published in

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volume

278

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issue

16

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page(s)

13959-67

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cites work

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Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria

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Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development.

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Leishmania mexicana mutants lacking glycosylphosphatidylinositol (GPI):protein transamidase provide insights into the biosynthesis and functions of GPI-anchored proteins.

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Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei

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Essential roles for GPI-anchored proteins in African trypanosomes revealed using mutants deficient in GPI8

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Glycosylphosphatidylinositol biosynthesis validated as a drug target for African sleeping sickness

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PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8

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Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins

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The GPI transamidase complex of Saccharomyces cerevisiae contains Gaa1p, Gpi8p, and Gpi16p

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The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase

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Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins

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Soluble GPI8 restores glycosylphosphatidylinositol anchoring in a trypanosome cell-free system depleted of lumenal endoplasmic reticulum proteins.

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Evidence for a role for the Dictyostelium Rap1 in cell viability and the response to osmotic stress

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Endoplasmic reticulum proteins involved in glycosylphosphatidylinositol-anchor attachment: photocrosslinking studies in a cell-free system.

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Early events in glycosylphosphatidylinositol anchor addition. substrate proteins associate with the transamidase subunit gpi8p

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The region encompassing the procyclic acidic repetitive protein (PARP) gene promoter plays a role in plasmid DNA replication in Trypanosoma brucei

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An unconventional role for cytoplasmic disulfide bonds in vaccinia virus proteins

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Requirements for glycosylphosphatidylinositol attachment are similar but not identical in mammalian cells and parasitic protozoa

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ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor

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Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex

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Glycoproteins form mixed disulphides with oxidoreductases during folding in living cells

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Temperature-sensitive yeast GPI anchoring mutants gpi2 and gpi3 are defective in the synthesis of N-acetylglucosaminyl phosphatidylinositol. Cloning of the GPI2 gene.

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Assembly of HLA DR1 molecules translated in vitro: binding of peptide in the endoplasmic reticulum precludes association with invariant chain.

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