Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase (Q24294818)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20696765%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase (English)

1 reference

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9 February 2020

0 references

1 reference

negative regulation of GTPase activity

1 reference

Rho GDP dissociation inhibitor (GDI) alpha

1 reference

Plexin B3

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author

Alan Yiu Wah Lee

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20696765%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

author name string

Xinhua Li

series ordinal

1

1 reference

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9 February 2020

language of work or name

English

0 references

publication date

9 August 2010

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9 February 2020

number of pages

10

1 reference

Journal of Biological Chemistry

inferred from page(s)

published in

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9 February 2020

volume

285

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9 February 2020

issue

42

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9 February 2020

page(s)

32436-32445

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Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells

9 February 2020

cites work

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Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF165 antagonizes this effect

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19 March 2017

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Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells

19 March 2017

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19 March 2017

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Binding of Rac1, Rnd1, and RhoD to a Novel Rho GTPase Interaction Motif Destabilizes Dimerization of the Plexin-B1 Effector Domain

19 March 2017

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19 March 2017

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19 March 2017

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The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras

19 March 2017

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Cross-talk between vascular endothelial growth factor and semaphorin-3A pathway in the regulation of normal and malignant mesothelial cell proliferation

19 March 2017

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Human malignant glioma cells express semaphorins and their receptors, neuropilins and plexins

19 March 2017

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The lamellipodium: where motility begins

19 March 2017

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Phosphorylation states of Cdc42 and RhoA regulate their interactions with Rho GDP dissociation inhibitor and their extraction from biological membranes

19 March 2017

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Genomic analysis of metastasis reveals an essential role for RhoC

19 March 2017

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The interaction between rac1 and its guanine nucleotide dissociation inhibitor (GDI), monitored by a single fluorescent coumarin attached to GDI

19 March 2017

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A novel regulator of p21-activated kinases

19 March 2017

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Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein

19 March 2017

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19 March 2017

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Cell migration: Rho GTPases lead the way

19 March 2017

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Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases

7 April 2017

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High gene expression of semaphorin 5A in pancreatic cancer is associated with tumor growth, invasion and metastasis

7 April 2017

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Expression of semaphorin 5A and its receptor plexin B3 contributes to invasion and metastasis of gastric carcinoma

27 September 2017

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The many faces of semaphorins: from development to pathology

27 September 2017

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27 September 2017

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Rac1 activity regulates proliferation of aggressive metastatic melanoma

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Semaphorin 4D/Plexin-B1-mediated R-Ras GAP activity inhibits cell migration by regulating beta(1) integrin activity

27 September 2017

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27 September 2017

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FARP2 triggers signals for Sema3A-mediated axonal repulsion

27 September 2017

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Proteolytic processing converts the repelling signal Sema3E into an inducer of invasive growth and lung metastasis

27 September 2017

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27 September 2017

Semaphorins in cancer

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ExoS Rho GTPase-activating protein activity stimulates reorganization of the actin cytoskeleton through Rho GTPase guanine nucleotide disassociation inhibitor

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho.

30 May 2018

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30 May 2018

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30 May 2018

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Phosphorylation of RhoGDI by p21-activated kinase 1.

30 May 2018

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PKC mediates cyclic stretch-induced cardiac hypertrophy through Rho family GTPases and mitogen-activated protein kinases in cardiomyocytes

21 January 2018

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Human semaphorin 6B [(HSA)SEMA6B], a novel human class 6 semaphorin gene: alternative splicing and all-trans-retinoic acid-dependent downregulation in glioblastoma cell lines.

21 January 2018

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Gene expression profiling and genetic markers in glioblastoma survival.

21 January 2018

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Plexin B mediates axon guidance in Drosophila by simultaneously inhibiting active Rac and enhancing RhoA signaling

21 January 2018

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Plexin signaling hampers integrin-based adhesion, leading to Rho-kinase independent cell rounding, and inhibiting lamellipodia extension and cell motility

21 January 2018

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Prognostic value of rho GTPases and rho guanine nucleotide dissociation inhibitors in human breast cancers.

21 January 2018

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Molecular dissection of the semaphorin 4D receptor plexin-B1-stimulated R-Ras GTPase-activating protein activity and neurite remodeling in hippocampal neurons

29 November 2018

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12 December 2020

Semaphorin 3C regulates endothelial cell function by increasing integrin activity

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12 December 2020

Poor outcome in estrogen receptor-positive breast cancers predicted by loss of plexin B1

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12 December 2020

Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer

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12 December 2020

The Rho small G protein family-Rho GDI system as a temporal and spatial determinant for cytoskeletal control

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12 December 2020

Identifiers

DOI

10.1074/JBC.M110.120451

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20696765%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20696765%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

PubMed publication ID

20696765

1 reference