Activation of mTORC2 by association with the ribosome (Q24294876)

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Daniele Stracka

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Wolfgang Oppliger

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Michael N Hall

Degradation of alpha-melanocyte stimulating hormone (alpha-MSH) by CALLA/endopeptidase 24.11 expressed by human melanoma cells in culture

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language of work or name

English

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publication date

4 March 2011

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published in

Cell

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volume

144

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issue

5

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page(s)

757-68

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cites work

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Functional and therapeutic significance of Akt deregulation in malignant melanoma.

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Eukaryotic ribosomes host PKC activity

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Emerging functions of ribosomal proteins in gene-specific transcription and translation

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Cells depleted for RPS19, a protein associated with Diamond Blackfan Anemia, show defects in 18S ribosomal RNA synthesis and small ribosomal subunit production.

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Concurrent blockade of the NF-kappaB and Akt pathways potently sensitizes cancer cells to chemotherapeutic-induced cytotoxicity

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mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice

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Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E

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TOR signaling in invertebrates

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TOR signaling in growth and metabolism

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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

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Functional specificity among ribosomal proteins regulates gene expression

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Regulation of translation initiation in eukaryotes: mechanisms and biological targets

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Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling

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Regulation of ceramide biosynthesis by TOR complex 2.

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

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mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

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How common are extraribosomal functions of ribosomal proteins?

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Rheb fills a GAP between TSC and TOR.

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Advances in protein kinase B signalling: AKTion on multiple fronts

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TOR complex 2: a signaling pathway of its own.

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2.

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

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Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast

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Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

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Expanding mTOR signaling

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Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

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The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

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mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

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Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly

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Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

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Does the ribosome translate cancer?

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Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy

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Identification of Protor as a novel Rictor-binding component of mTOR complex-2

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TOR regulation of AGC kinases in yeast and mammals

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PKCbetaII modulates translation independently from mTOR and through RACK1.

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

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High density oligonucleotide array analysis of interferon- alpha2a sensitivity and transcriptional response in melanoma cells

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The Saccharomyces cerevisiae TSC10/YBR265w gene encoding 3-ketosphinganine reductase is identified in a screen for temperature-sensitive suppressors of the Ca2+-sensitive csg2Delta mutant

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Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival

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The fate of membrane-bound ribosomes following the termination of protein synthesis

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FKBP12-Rapamycin-associated Protein or Mammalian Target of Rapamycin (FRAP/mTOR) Localization in the Endoplasmic Reticulum and the Golgi Apparatus

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Molecular organization of target of rapamycin complex 2.

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mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

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Mutual antagonism of target of rapamycin and calcineurin signaling

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Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis

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Suboptimal activation of melanoma infiltrating lymphocytes (TIL) due to low avidity of TCR/MHC-tumor peptide interactions

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Endoplasmic reticulum and Golgi localization sequences for mammalian target of rapamycin

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Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

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The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma

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A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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TOR1 and TOR2 have distinct locations in live cells

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Saccharomyces cerevisiae Nip7p is required for efficient 60S ribosome subunit biogenesis.

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Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1

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Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization

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7 January 2021

Amino acid regulation of TOR complex 1.

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Deregulated Akt3 activity promotes development of malignant melanoma

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mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor

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The role of Myc-induced protein synthesis in cancer

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Targeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancer

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mTOR signaling at a glance

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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

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PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.

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