mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes (Q42809294)

7 November 2017

mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes (English)

1 reference

7 November 2017

1 reference

Richard C Hresko

1

1 reference

PubMed ID

16221682

7 November 2017

Mike Mueckler

series ordinal

2

1 reference

PubMed ID

16221682

7 November 2017

language of work or name

English

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publication date

11 October 2005

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Journal of Biological Chemistry

7 November 2017

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7 November 2017

280

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7 November 2017

40406-40416

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7 November 2017

49

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Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site

7 November 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

A role for protein kinase Bbeta/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Insulin stimulation of GLUT4 exocytosis, but not its inhibition of endocytosis, is dependent on RabGAP AS160.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Role of protein kinase B in insulin-regulated glucose uptake.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Insulin signalling and the regulation of glucose and lipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

The IRS-signalling system: a network of docking proteins that mediate insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

The PI3K-PDK1 connection: more than just a road to PKB

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Role of translocation in the activation and function of protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Multiple pathways control protein kinase C phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Crystal structure of an inactive Akt2 kinase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Phosphoinositide-dependent kinase-2 is a distinct protein kinase enriched in a novel cytoskeletal fraction associated with adipocyte plasma membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

The DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Reconstitution of phosphoinositide 3-kinase-dependent insulin signaling in a cell-free system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Differential regulation of two distinct glucose transporter species expressed in 3T3-L1 adipocytes: effect of chronic insulin and tolbutamide treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Insulin-stimulated translocation of glucose transporters in the isolated rat adipose cells: Characterization of subcellular fractions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

FKBP12-Rapamycin-associated Protein or Mammalian Target of Rapamycin (FRAP/mTOR) Localization in the Endoplasmic Reticulum and the Golgi Apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Regulation of protein kinase B/Akt activity and Ser473 phosphorylation by protein kinase Calpha in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Integrin-linked kinase regulates chondrocyte shape and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Knockout of PKC alpha enhances insulin signaling through PI3K

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

Involvement of the pleckstrin homology domain in the insulin-stimulated activation of protein kinase B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508361200

21 January 2018

Identifiers

DOI

10.1074/JBC.M508361200

1 reference

7 November 2017

1 reference

PubMed ID

16221682