The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP (Q24295229)

2

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Javier Girardini

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Paul Smith

4

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Milena Gasco

5

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Xin Lu

6

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Tim Crook

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Giannino Del Sal

Nature Structural & Molecular Biology

8

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language of work or name

English

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publication date

October 2007

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published in

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volume

14

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page(s)

912-20

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issue

10

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cites work

Primary structure polymorphism at amino acid residue 72 of human p53.

1 reference

Two polymorphic variants of wild-type p53 differ biochemically and biologically

21 January 2018

1 reference

Prevalent overexpression of prolyl isomerase Pin1 in human cancers

21 January 2018

1 reference

Post-translational modifications and activation of p53 by genotoxic stresses

21 January 2018

1 reference

The complexity of p53 stabilization and activation

31 March 2020

1 reference

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

31 March 2020

1 reference

Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo

31 March 2020

1 reference

Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate.

31 March 2020

1 reference

Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis

31 March 2020

1 reference

Acetylation of the p53 DNA-binding domain regulates apoptosis induction

31 March 2020

1 reference

On the mechanism of sequence-specific DNA-dependent acetylation of p53: the acetylation motif is exposed upon DNA binding

31 March 2020

1 reference

Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism

31 March 2020

1 reference

PIN1, the cell cycle and cancer.

31 March 2020

1 reference

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

31 March 2020

1 reference

Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.

31 March 2020

1 reference

Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

31 March 2020

1 reference

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

31 March 2020

1 reference

CDK9 phosphorylates p53 on serine residues 33, 315 and 392

31 March 2020

1 reference

Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases

31 March 2020

1 reference

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

31 March 2020

1 reference

The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.

31 March 2020

1 reference

Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage

31 March 2020

1 reference

Mutations in proline 82 of p53 impair its activation by Pin1 and Chk2 in response to DNA damage

31 March 2020

1 reference

Identification of a novel p53 functional domain that is necessary for efficient growth suppression

31 March 2020

1 reference

A Role for the Polyproline Domain of p53 in Its Regulation by Mdm2

31 March 2020

1 reference

The Proline Repeat Domain of p53 Binds Directly to the Transcriptional Coactivator p300 and Allosterically Controls DNA-Dependent Acetylation of p53

31 March 2020

1 reference

The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression

31 March 2020

1 reference

Differential regulation of cellular target genes by p53 devoid of the PXXP motifs with impaired apoptotic activity

31 March 2020

1 reference

A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network

31 March 2020

1 reference

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

31 March 2020

1 reference

iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

31 March 2020

1 reference

iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53.

31 March 2020

1 reference

Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo

31 March 2020

1 reference

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

31 March 2020

1 reference

Pin1 links the activities of c-Abl and p300 in regulating p73 function.

31 March 2020

1 reference

Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1).

31 March 2020

1 reference

Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases

31 March 2020

1 reference

Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins

31 March 2020

1 reference

Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes

31 March 2020

1 reference

Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation

31 March 2020

1 reference

Oncogenic forms of p53 inhibit p53-regulated gene expression

31 March 2020

1 reference

DNA-dependent acetylation of p53 by the transcription coactivator p300.

31 March 2020

1 reference

Inhibition of p53-dependent transcription by BOX-I phospho-peptide mimetics that bind to p300.

31 March 2020

1 reference

Phosphorylation-specific prolyl isomerization: is there an underlying theme?

31 March 2020

1 reference

Pin1 modulates the structure and function of human RNA polymerase II.

31 March 2020

1 reference

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

31 March 2020

1 reference

Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified.

31 March 2020

1 reference

ASPP proteins specifically stimulate the apoptotic function of p53

31 March 2020

1 reference

Cyclin E ablation in the mouse

31 March 2020

1 reference

MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents

31 March 2020

1 reference

Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo

31 March 2020

1 reference