Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1). (Q34520098)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16537920%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

title

Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1) (English)

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18 January 2020

9

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18 January 2020

Wei-Guo Zhu

13

1 reference

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18 January 2020

author name string

Ying Zhao

1

1 reference

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18 January 2020

Shaoli Lu

2

1 reference

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18 January 2020

Lipeng Wu

3

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18 January 2020

Guolin Chai

4

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18 January 2020

Haiying Wang

5

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18 January 2020

Yingqi Chen

6

1 reference

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18 January 2020

Jia Sun

7

1 reference

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18 January 2020

Yu Yu

8

1 reference

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18 January 2020

Quanhui Zheng

10

1 reference

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18 January 2020

Mian Wu

11

1 reference

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18 January 2020

Gregory A Otterson

12

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18 January 2020

language of work or name

English

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publication date

1 April 2006

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Molecular and Cellular Biology

18 January 2020

published in

1 reference

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18 January 2020

volume

26

1 reference

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18 January 2020

issue

7

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18 January 2020

page(s)

2782-2790

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p53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrest

18 January 2020

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The ubiquitin ligase COP1 is a critical negative regulator of p53

7 July 2018

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Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo

7 July 2018

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Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation

7 July 2018

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5-aza-2'-deoxycytidine activates the p53/p21Waf1/Cip1 pathway to inhibit cell proliferation.

7 July 2018

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The Proline Repeat Domain of p53 Binds Directly to the Transcriptional Coactivator p300 and Allosterically Controls DNA-Dependent Acetylation of p53

7 July 2018

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Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

7 July 2018

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Histone deacetylase inhibitors activate p21(WAF1) expression via ATM.

7 July 2018

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Methylation of adjacent CpG sites affects Sp1/Sp3 binding and activity in the p21(Cip1) promoter

7 July 2018

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The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells.

7 July 2018

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The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene.

7 July 2018

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Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

7 July 2018

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Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

7 July 2018

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7 July 2018

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Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity.

7 July 2018

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MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

7 July 2018

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Histone-deacetylase inhibitors: novel drugs for the treatment of cancer

7 July 2018

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Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo

7 July 2018

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Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

7 July 2018

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7 July 2018

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

7 July 2018

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Negative control of p53 by Sir2alpha promotes cell survival under stress

7 July 2018

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7 July 2018

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Post-translational modifications and activation of p53 by genotoxic stresses

7 July 2018

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7 July 2018

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p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

7 July 2018

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p53 accumulates but is functionally impaired when DNA synthesis is blocked

7 July 2018

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Deacetylation of p53 modulates its effect on cell growth and apoptosis

7 July 2018

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The function of PML in p53-dependent apoptosis

7 July 2018

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Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells

7 July 2018

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Histone deacetylases specifically down-regulate p53-dependent gene activation

7 July 2018

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The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

7 July 2018

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Stimulation of p53 DNA binding by c-Abl requires the p53 C terminus and tetramerization

7 July 2018

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Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

7 July 2018

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7 July 2018

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7 July 2018

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p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

7 July 2018

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7 July 2018

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DNA damage activates p53 through a phosphorylation-acetylation cascade

7 July 2018

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FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor.

7 July 2018

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

7 July 2018

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Reciprocal interference between the sequence-specific core and nonspecific C-terminal DNA binding domains of p53: implications for regulation

7 July 2018

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Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

7 July 2018

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Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line

7 July 2018

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Binding and modulation of p53 by p300/CBP coactivators

7 July 2018

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Regulation of p53 stability by Mdm2

7 July 2018

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Mdm2 promotes the rapid degradation of p53

7 July 2018

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p53, the cellular gatekeeper for growth and division

7 July 2018

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7 July 2018

p53: puzzle and paradigm

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Allosteric activation of latent p53 tetramers

7 July 2018

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Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus

7 July 2018

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Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases

7 July 2018

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Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases

7 July 2018

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Amplification of a gene encoding a p53-associated protein in human sarcomas

7 July 2018

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

7 July 2018

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p53 linear diffusion along DNA requires its C terminus

7 July 2018

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Acetylation of p53 inhibits its ubiquitination by Mdm2.

27 October 2018

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Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.

27 October 2018

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DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors.

27 October 2018

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Effects of a novel antitumor depsipeptide, FR901228, on human breast cancer cells.

27 October 2018

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Small peptides activate the latent sequence-specific DNA binding function of p53.

27 October 2018

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Phosphorylation of p53 serine 15 increases interaction with CBP

27 October 2018

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12 December 2020

Transcriptional Regulation of the p21(WAF1/CIP1)Gene

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Acetylation control of the retinoblastoma tumour-suppressor protein

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Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases

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12 December 2020

Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228

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12 December 2020

10.1128/MCB.26.7.2782-2790.2006

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DOI

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18 January 2020

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18 January 2020

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