Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis (Q24295251)

Extracellular matrix protein 1

GOA release 2020-03-11

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protein C-terminus binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

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Maurizio Mongiat

1

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Jian Fu

2

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Rachel Oldershaw

3

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Robert Greenhalgh

4

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Allen M Gown

5

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Renato V Iozzo

Journal of Biological Chemistry

6

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language of work or name

English

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publication date

9 May 2003

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published in

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volume

278

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issue

19

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page(s)

17491-9

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cites work

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Perlecan: a gem of a proteoglycan

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Perlecan and basement membrane-chondroitin sulfate proteoglycan (bamacan) are two basement membrane chondroitin/dermatan sulfate proteoglycans in the Engelbreth-Holm-Swarm tumor matrix

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Developmental expression of perlecan during murine embryogenesis

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Antibody mapping and tissue localization of globular and cysteine-rich regions of perlecan domain III.

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Biosynthesis of heparan sulfate proteoglycan by human colon carcinoma cells and its localization at the cell surface

21 January 2018

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Interaction of skeletal muscle cells with collagen type IV is mediated by perlecan associated with the cell surface

21 January 2018

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Recombinant domain III of perlecan promotes cell attachment through its RGDS sequence

21 January 2018

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The C-terminal domain V of perlecan promotes beta1 integrin-mediated cell adhesion, binds heparin, nidogen and fibulin-2 and can be modified by glycosaminoglycans

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Endothelial cells interact with the core protein of basement membrane perlecan through beta 1 and beta 3 integrins: an adhesion modulated by glycosaminoglycan

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Perlecan is essential for cartilage and cephalic development

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210529200

Perlecan maintains the integrity of cartilage and some basement membranes

21 January 2018

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Dyssegmental dysplasia, Silverman-Handmaker type, is caused by functional null mutations of the perlecan gene.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210529200

Dyssegmental dysplasia, Silverman-Handmaker type: unexpected role of perlecan in cartilage development

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Hyperplastic conotruncal endocardial cushions and transposition of great arteries in perlecan-null mice.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210529200

The biology of perlecan: the multifaceted heparan sulphate proteoglycan of basement membranes and pericellular matrices

21 January 2018

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Perlecan is required to inhibit thrombosis after deep vascular injury and contributes to endothelial cell-mediated inhibition of intimal hyperplasia

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210529200

Human perlecan immunopurified from different endothelial cell sources has different adhesive properties for vascular cells.

21 January 2018

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Heparan sulfate proteoglycans: heavy hitters in the angiogenesis arena

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Order out of chaos: assembly of ligand binding sites in heparan sulfate

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Heparan sulfate proteoglycans: intricate molecules with intriguing functions.

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Specific binding of basic fibroblast growth factor to basement membrane-like structures and to purified heparan sulfate proteoglycan of the EHS tumor.

21 January 2018

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Recombinant domain IV of perlecan binds to nidogens, laminin-nidogen complex, fibronectin, fibulin-2 and heparin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210529200

Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210529200

Acetylcholinesterase clustering at the neuromuscular junction involves perlecan and dystroglycan

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210529200

Mapping of the binding of platelet-derived growth factor to distinct domains of the basement membrane proteins BM-40 and perlecan and distinction from the BM-40 collagen-binding epitope

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210529200

The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210529200

Fibroblast growth factor-binding protein is a novel partner for perlecan protein core

21 January 2018

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Characterization of the osteogenic stromal cell line MN7: identification of secreted MN7 proteins using two-dimensional polyacrylamide gel electrophoresis, western blotting, and microsequencing

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210529200

Alternative splicing of the Endo16 transcript produces differentially expressed mRNAs during sea urchin gastrulation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210529200

The human extracellular matrix gene 1 (ECM1): genomic structure, cDNA cloning, expression pattern, and chromosomal localization

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210529200

Molecular cloning, characterization, and genetic mapping of the cDNA coding for a novel secretory protein of mouse. Demonstration of alternative splicing in skin and cartilage

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210529200

Recombinant human extracellular matrix protein 1 inhibits alkaline phosphatase activity and mineralization of mouse embryonic metatarsals in vitro

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210529200

Extracellular matrix protein 1 (ECM1) has angiogenic properties and is expressed by breast tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210529200

Lipoid proteinosis maps to 1q21 and is caused by mutations in the extracellular matrix protein 1 gene (ECM1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210529200

Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210529200

Two-hybrid analysis reveals multiple direct interactions for thrombospondin 1

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210529200

Self-assembly and supramolecular organization of EMILIN

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210529200

Type VI collagen anchors endothelial basement membranes by interacting with type IV collagen

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210529200

Structure and function of laminin LG modules

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210529200

Perlecan domain V of Drosophila melanogaster. Sequence, recombinant analysis and tissue expression

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210529200

Structure, function and tissue forms of the C-terminal globular domain of collagen XVIII containing the angiogenesis inhibitor endostatin

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210529200

Structural basis and potential role of heparin/heparan sulfate binding to the angiogenesis inhibitor endostatin

21 January 2018

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Endostatins derived from collagens XV and XVIII differ in structural and binding properties, tissue distribution and anti-angiogenic activity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210529200

Molecular cloning and characterization of the mouse Ecm1 gene and its 5' regulatory sequences

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210529200

Expression of the heparan sulfate proteoglycan, perlecan, during mouse embryogenesis and perlecan chondrogenic activity in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210529200

Chondrogenic activity of the heparan sulfate proteoglycan perlecan maps to the N-terminal domain I

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210529200

Vascular cell-derived heparan sulfate shows coupled inhibition of basic fibroblast growth factor binding and mitogenesis in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210529200

Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210529200

The role of collagen-derived proteolytic fragments in angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210529200

Distinct antitumor properties of a type IV collagen domain derived from basement membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210529200

Angiogenesis in cancer, vascular, rheumatoid and other disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210529200

Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210529200

The N-terminal globular domain of the laminin alpha1 chain binds to alpha1beta1 and alpha2beta1 integrins and to the heparan sulfate-containing domains of perlecan

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210529200

Heparan sulfate proteoglycan (perlecan) expression by mouse embryos during acquisition of attachment competence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210529200

Widespread expression of perlecan proteoglycan in basement membranes and extracellular matrices of human tissues as detected by a novel monoclonal antibody against domain III and by in situ hybridization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210529200

Structural basis of glycosaminoglycan modification and of heterotypic interactions of perlecan domain V

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210529200

Pieces of eight: bioactive fragments of extracellular proteins as regulators of angiogenesis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210529200

Mammalian tissue distribution of a large heparan sulfate proteoglycan detected by monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210529200