Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry (Q24295282)

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English	Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry	scientific article

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3 March 2020

Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry (English)

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3 March 2020

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3 March 2020

Judith Nicholson

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3 March 2020

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Lenka Hernychova

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3 March 2020

Chandra Verma

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3 March 2020

Carrie-Anne Sharma

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3 March 2020

Eva Ruckova

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3 March 2020

Jin Yuan Teo

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3 March 2020

Kathryn Ball

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3 March 2020

Borek Vojtesek

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3 March 2020

Ted R Hupp

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1 August 2013

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3 March 2020

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3 March 2020

13

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3 March 2020

16

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3 March 2020

2512-2525

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3 March 2020

Concepts in MDM2 Signaling: Allosteric Regulation and Feedback Loops

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding.

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

Binding of p53-derived ligands to MDM2 induces a variety of long range conformational changes.

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

Solution structure of the C4 zinc finger domain of HDM2.

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

The effects of phosphomimetic lid mutation on the thermostability of the N-terminal domain of MDM2.

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

Regulation of the E3 ubiquitin ligase activity of MDM2 by an N-terminal pseudo-substrate motif

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

The central region of HDM2 provides a second binding site for p53.

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

MDM2 chaperones the p53 tumor suppressor

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1.

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

The p53 mRNA-Mdm2 interaction controls Mdm2 nuclear trafficking and is required for p53 activation following DNA damage

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

P53 mRNA controls p53 activity by managing Mdm2 functions

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

Structural characterization of intrinsically disordered proteins by the combined use of NMR and SAXS.

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

An iTRAQ proteomics screen reveals the effects of the MDM2 binding ligand Nutlin-3 on cellular proteostasis.

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

C-terminal substitution of MDM2 interacting peptides modulates binding affinity by distinctive mechanisms

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

Insights into the conformational dynamics of the E3 ubiquitin ligase CHIP in complex with chaperones and E2 enzymes.

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

Understanding small-molecule binding to MDM2: insights into structural effects of isoindolinone inhibitors from NMR spectroscopy

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

Design of a novel MDM2 binding peptide based on the p53 family

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

Chemical states of the N-terminal "lid" of MDM2 regulate p53 binding: simulations reveal complexities of modulation

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

Flexible lid to the p53-binding domain of human Mdm2: implications for p53 regulation

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2.

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

The calcium-binding domain of the stress protein SEP53 is required for survival in response to deoxycholic acid-mediated injury

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

Non-degradative ubiquitination of the Notch1 receptor by the E3 ligase MDM2 activates the Notch signalling pathway

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

Solution Structure of the Hdm2 C2H2C4 RING, a Domain Critical for Ubiquitination of p53

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

21 January 2018

Dual-site regulation of MDM2 E3-ubiquitin ligase activity

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300029

7 January 2021

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Multiple peptide conformations give rise to similar binding affinities: molecular simulations of p53-MDM2

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https://api.crossref.org/works/10.1002%2FPMIC.201300029

7 January 2021

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Identifiers

10.1002/PMIC.201300029

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3 March 2020

release_3lur5iu7a5cu7jh4pgo34bnp6a

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24 November 2022

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mapped directly with Wikidata item

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3 March 2020

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