Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain (Q24314763)

ubiquitin protein ligase binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

P H Kussie

1

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S Gorina

2

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V Marechal

3

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B Elenbaas

4

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J Moreau

5

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A J Levine

6

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N P Pavletich

Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

7

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language of work or name

English

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publication date

8 November 1996

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published in

Science

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volume

274

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page(s)

948-53

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issue

5289

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cites work

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p53-dependent apoptosis suppresses tumor growth and progression in vivo

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Structure and function of transcriptional activation domains

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Structure of the human class I histocompatibility antigen, HLA-A2

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Amplification of a gene encoding a p53-associated protein in human sarcomas

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

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Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1.

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p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

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Interaction between the retinoblastoma protein and the oncoprotein MDM2

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Definition of a consensus binding site for p53

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Pattern of aromatic and hydrophobic amino acids critical for one of two subdomains of the VP16 transcriptional activator

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A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activation

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p53 and E2F-1 cooperate to mediate apoptosis

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Human TAFII31 protein is a transcriptional coactivator of the p53 protein

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Transactivation ability of p53 transcriptional activation domain is directly related to the binding affinity to TATA-binding protein

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p53: puzzle and paradigm

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The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots

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Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

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