The RAG1 N-terminal domain is an E3 ubiquitin ligase (Q24297482)

Ubiquitin conjugating enzyme E2 C

1 reference

ubiquitin activating enzyme activity

1 reference

Recombination activating gene 2

1 reference

Recombination activating 1

1 reference

Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains

author name string

Vyacheslav Yurchenko

series ordinal

1

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Zhu Xue

series ordinal

2

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Moshe Sadofsky

series ordinal

3

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language of work or name

English

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publication date

1 March 2003

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published in

Genes & Development

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volume

17

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issue

5

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page(s)

581-5

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

Histone ubiquitination: a tagging tail unfolds?

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

Themes and variations on ubiquitylation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

Expression and V(D)J recombination activity of mutated RAG-1 proteins

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

RING finger ubiquitin protein ligases: implications for tumorigenesis, metastasis and for molecular targets in cancer

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

A RAG-1/RAG-2 tetramer supports 12/23-regulated synapsis, cleavage, and transposition of V(D)J recombination signals

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

Ordered assembly of the V(D)J synaptic complex ensures accurate recombination

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

V(D)J recombination: RAG proteins, repair factors, and regulation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

The mechanism and regulation of chromosomal V(D)J recombination

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

Assembly of the RAG1/RAG2 synaptic complex

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

Functional organization of single and paired V(D)J cleavage complexes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

The RAG proteins in V(D)J recombination: more than just a nuclease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

A C-terminal region of RAG1 contacts the coding DNA during V(D)J recombination.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

N-terminal RAG1 frameshift mutations in Omenn's syndrome: internal methionine usage leads to partial V(D)J recombination activity and reveals a fundamental role in vivo for the N-terminal domains.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

Dual role of RAG2 in V(D)J recombination: catalysis and regulation of ordered Ig gene assembly

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

A basic motif in the N-terminal region of RAG1 enhances V(D)J recombination activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

Analysis of regions of RAG-2 important for V(D)J recombination

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

Definition of a core region of RAG-2 that is functional in V(D)J recombination

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

RAG2 is down-regulated by cytoplasmic sequestration and ubiquitin-dependent degradation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=196008

Regions of RAG1 protein critical for V(D)J recombination

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12629039

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A zinc-binding domain involved in the dimerization of RAG1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12629039

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The U box is a modified RING finger — a common domain in ubiquitination

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12629039

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1101/GAD.1058103

1 reference

4496756

4496756

1 reference

1 reference

1 reference