RING finger ubiquitin protein ligases: implications for tumorigenesis, metastasis and for molecular targets in cancer (Q35036565)

5 August 2017

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title

RING finger ubiquitin protein ligases: implications for tumorigenesis, metastasis and for molecular targets in cancer (English)

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5 August 2017

Shengyun Fang

1

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5 August 2017

Kevin L Lorick

series ordinal

2

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5 August 2017

Jane P Jensen

series ordinal

3

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5 August 2017

Allan M Weissman

series ordinal

4

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5 August 2017

1 February 2003

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Seminars in Cancer Biology

5 August 2017

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5 August 2017

13

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5 August 2017

1

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5 August 2017

5-14

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https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

5 August 2017

1 reference

7 January 2021

Themes and variations on ubiquitylation

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https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

A new ticket for entry into budding vesicles-ubiquitin

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https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Inactivation of the HR6B ubiquitin-conjugating DNA repair enzyme in mice causes male sterility associated with chromatin modification.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

C-terminal ubiquitination of p53 contributes to nuclear export

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

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https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Regulation of transcriptional activation domain function by ubiquitin

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https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Mechanisms underlying ubiquitination

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https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

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https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade

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https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Characterization of Human hect Domain Family Members and Their Interaction with UbcH5 and UbcH7

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

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https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Identification and preliminary characterization of a protein motif related to the zinc finger

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https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

The RING finger. A novel protein sequence motif related to the zinc finger.

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https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

RING for destruction?

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https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

RING finger proteins: mediators of ubiquitin ligase activity

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https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

The E2-E3 interaction in the N-end rule pathway: the RING-H2 finger of E3 is required for the synthesis of multiubiquitin chain

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

The U box is a modified RING finger — a common domain in ubiquitination

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https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.

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https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

U box proteins as a new family of ubiquitin-protein ligases

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

The leukemia-associated-protein (LAP) domain, a cysteine-rich motif, is present in a wide range of proteins, including MLL, AF10, and MLLT6 proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

MHC class I ubiquitination by a viral PHD/LAP finger protein.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

SP-RING for SUMO: new functions bloom for a ubiquitin-like protein

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https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases

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https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Involvement of PIAS1 in the sumoylation of tumor suppressor p53

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Dnmt3b, de novo DNA methyltransferase, interacts with SUMO-1 and Ubc9 through its N-terminal region and is subject to modification by SUMO-1

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Yeast Ull1/Siz1 is a novel SUMO1/Smt3 ligase for septin components and functions as an adaptor between conjugating enzyme and substrates

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Herpes simplex virus 1-infected cell protein 0 contains two E3 ubiquitin ligase sites specific for different E2 ubiquitin-conjugating enzymes

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https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

The nucleoporin RanBP2 has SUMO1 E3 ligase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Regulation of TRAF2 signaling by self-induced degradation.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

MDM2 interacts with MDMX through their RING finger domains

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

MdmX protects p53 from Mdm2-mediated degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Cancer susceptibility and the functions of BRCA1 and BRCA2

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Molecular pathogenesis of fanconi anemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Positional cloning of a novel Fanconi anemia gene, FANCD2

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https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Mapping the functional domains of BRCA1. Interaction of the ring finger domains of BRCA1 and BARD1

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

BARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear export

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Tumor cell motility and metastasis : Autocrine motility factor as an example of ecto/exoenzyme cytokines.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Autocrine motility factor and its receptor: role in cell locomotion and metastasis

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Identification of genes differentially induced by hypoxia in pancreatic cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Tumor autocrine motility factor is an angiogenic factor that stimulates endothelial cell motility

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Retrograde protein translocation: ERADication of secretory proteins in health and disease

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Ubiquitin and the control of protein fate in the secretory and endocytic pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s)

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Role of Cue1p in ubiquitination and degradation at the ER surface

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

HRD gene dependence of endoplasmic reticulum-associated degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Novel aspects of degradation of T cell receptor subunits from the endoplasmic reticulum (ER) in T cells: importance of oligosaccharide processing, ubiquitination, and proteasome-dependent removal from ER membranes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Crystal structure of a class I ubiquitin conjugating enzyme (Ubc7) from Saccharomyces cerevisiae at 2.9 angstroms resolution

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Inverse relation of autocrine motility factor receptor and E-cadherin expression following MDCK epithelial cell transformation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Localization of autocrine motility factor receptor to caveolae and clathrin-independent internalization of its ligand to smooth endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Caveolin-1 is a negative regulator of caveolae-mediated endocytosis to the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Proteasome inhibition in cancer: development of PS-341.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

NF-kappa B as a therapeutic target in multiple myeloma

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

26S proteasome inhibition induces apoptosis and limits growth of human pancreatic cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Inhibition of proteasome function induces programmed cell death in proliferating endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Identification of ubiquitin ligases required for skeletal muscle atrophy

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

SCF ubiquitin protein ligases and phosphorylation-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Proteolysis and the cell cycle: with this RING I do thee destroy

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Skp2 is oncogenic and overexpressed in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Protein destruction: adapting roles for Cks proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

S-phase kinase-associated protein 2 expression in non-Hodgkin's lymphoma inversely correlates with p27 expression and defines cells in S phase

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Ubiquitin-mediated degradation of cellular proteins in health and disease

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Regulation of p53 stability

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Functions of the MDM2 oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Ubiquitous induction of p53 in tumor cells by antisense inhibition of MDM2 expression.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Ubiquitin, E6-AP, and their role in p53 inactivation.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900095-0

7 January 2021

10.1016/S1044-579X(02)00095-0

Identifiers

DOI

1 reference

5 August 2017

1 reference