APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain (Q24297668)

GOA release 2020-03-11

neuron apoptotic process

1 reference

GOA release 2020-03-11

author name string

Yuzhi Chen

1

0 references

Wenyun Liu

2

0 references

Linda Hassinger

4

0 references

Donna L. McPhie

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14557245

21 March 2024

Rachael L. Neve

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14557245

full work available at URL

21 March 2024

language of work or name

English

0 references

publication date

13 October 2003

0 references

number of pages

7

1 reference

based on heuristic

inferred from page(s)

https://rupress.org/jcb/article-pdf/163/1/27/1311092/jcb163127.pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14557245

https://europepmc.org/articles/PMC2173435

21 March 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14557245

https://europepmc.org/articles/PMC2173435?pdf=render

21 March 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14557245

https://rupress.org/jcb/article-pdf/163/1/27/1867998/jcb163127.pdf

21 March 2024

file format

Portable Document Format

1 reference

DOI

10.1083/JCB.200304003

https://api.crossref.org/works/10.1083/JCB.200304003

ASPP2 inhibits APP‐BP1‐mediated NEDD8 conjugation to cullin‐1 and decreases APP‐BP1‐induced cell proliferation and neuronal apoptosis

21 March 2024

published in

Journal of Cell Biology

0 references

volume

163

0 references

issue

1

0 references

page(s)

27-33

0 references

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173435

The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173435

APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein

19 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173435

19 March 2017

https://api.crossref.org/works/10.1083%2FJCB.200304003

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173435

Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor protein

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173435

DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173435

Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173435

A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173435

Extracellular simian virus 40 transmits a signal that promotes virus enclosure within caveolae

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173435

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o)

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173435

Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173435

Alzheimer's beta-amyloid precursor protein is expressed on the surface of immediately ex vivo brain cells: a flow cytometric study.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173435

Immunotherapy as a therapeutic treatment for neurodegenerative disorders.

30 May 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200304003

Caspase cleavage of members of the amyloid precursor family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200304003

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200304003

The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200304003

Neuronal expression of beta-amyloid precursor protein Alzheimer mutations causes intracellular accumulation of a C-terminal fragment containing both the amyloid beta and cytoplasmic domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200304003

beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200304003

A 127-kDa protein (UV-DDB) binds to the cytoplasmic domain of the Alzheimer's amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200304003

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200304003

Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173435

DNA replication precedes neuronal cell death in Alzheimer's disease.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173435

The transcriptional activity of the APP intracellular domain-Fe65 complex is inhibited by activation of the NF-kappaB pathway

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/14557245

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

G1/S cell cycle blockers and inhibitors of cyclin-dependent kinases suppress camptothecin-induced neuronal apoptosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/14557245