DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3 (Q28573591)

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English	DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3	scientific journal article

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scholarly article

1 reference

31 January 2017

DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3 (English)

2 references

31 January 2017

Europe PubMed Central

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12 May 2020

apoptotic process

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Alzheimer's disease

1 reference

based on heuristic

inferred from title

early-onset autosomal dominant Alzheimer disease

1 reference

based on heuristic

inferred from title

Rachael L. Neve

9

object named as

Rachael L Neve

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12 May 2020

author name string

Robert Coopersmith

2

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31 January 2017

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12 May 2020

Andrew Hines-Peralta

3

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31 January 2017

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12 May 2020

Yuzhi Chen

4

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31 January 2017

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12 May 2020

Donna L McPhie

1

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12 May 2020

Kathryn J Ivins

5

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12 May 2020

Susan P Manly

6

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12 May 2020

Michael R Kozlowski

7

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12 May 2020

Kim A Neve

8

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12 May 2020

language of work or name

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publication date

30 July 2003

1 reference

31 January 2017

Journal of Neuroscience

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31 January 2017

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12 May 2020

23

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12 May 2020

17

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12 May 2020

6914-6927

1 reference

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12 May 2020

The amyloid precursor protein interacts with Go heterotrimeric protein within a cell compartment specialized in signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A monoclonal antibody to amyloid precursor protein induces neuronal apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path?

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA replication precedes neuronal cell death in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspases, apoptosis, and Alzheimer disease: causation, correlation, and confusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p21-activated kinases: three more join the Pak.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysregulation of neuronal differentiation and cell cycle control in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptotic promoters and inhibitors in Alzheimer's disease: Who wins out?

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the omega-conotoxin-sensitive calcium current by distinct G proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neurotoxic carboxy-terminal fragment of the Alzheimer amyloid precursor binds specifically to a neuronal cell surface molecule: pH dependence of the neurotoxicity and the binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neuronal growth-associated protein GAP-43 (B-50, F1): neuronal specificity, developmental regulation and regional distribution of the human and rat mRNAs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a mouse p21Cdc42/Rac activated kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and Molecular Cloning of a p21cdc42/rac1-activated Serine/Threonine Kinase That Is Rapidly Activated by Thrombin in Platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A potential role for apoptosis in neurodegeneration and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical evidence for apoptosis in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ki-67 immunoreactivity in Alzheimer's disease and other neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of a Cdc2-related kinase associated with Alzheimer paired helical filaments.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligand-dependent G protein coupling function of amyloid transmembrane precursor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A dominant truncation allele identifies a gene, STE20, that encodes a putative protein kinase necessary for mating in Saccharomyces cerevisiae

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o)

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell cycle blockers mimosine, ciclopirox, and deferoxamine prevent the death of PC12 cells and postmitotic sympathetic neurons after removal of trophic support

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning and sequencing of the cytostatic G protein-activated protein kinase PAK I.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitotic mechanisms in Alzheimer's disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rab11 regulates recycling through the pericentriolar recycling endosome

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease neurofibrillary tangles contain mitosis-specific phosphoepitopes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Annexin I targets S100C to early endosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal expression of beta-amyloid precursor protein Alzheimer mutations causes intracellular accumulation of a C-terminal fragment containing both the amyloid beta and cytoplasmic domains.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of a G-protein beta-subunit with a conserved sequence in Ste20/PAK family protein kinases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degeneration in vivo of rat hippocampal neurons by wild-type Alzheimer amyloid precursor protein overexpressed by adenovirus-mediated gene transfer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinase suppressor of Ras inhibits the activation of extracellular ligand-regulated (ERK) mitogen-activated protein (MAP) kinase by growth factors, activated Ras, and Ras effectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression profiles of multiple genes in single neurons of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitotic phosphoepitopes precede paired helical filaments in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12890786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.23-17-06914.2003

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740729&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740729&resulttype=core&format=json

12 May 2020

2 references

31 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740729&resulttype=core&format=json

12 May 2020

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