The human interleukin-6 (IL-6) receptor exists as a preformed dimer in the plasma membrane (Q24297675)

protein homodimerization activity

GOA release 2020-03-11

1 reference

IL-6 type cytokine receptor complexes: hexamer, tetramer or both?

GOA release 2020-03-11

Stefan Rose-John

3

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Karl-Josef Kallen

series ordinal

4

object named as

Karl-Josef Kallen

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author name string

Björn Schuster

series ordinal

1

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Werner Meinert

series ordinal

2

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language of work or name

English

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publication date

13 March 2003

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published in

FEBS Letters

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volume

538

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issue

1-3

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page(s)

113-6

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cites work

1 reference

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The signal transducer gp130: Solution structure of the carboxy-terminal domain of the cytokine receptor homology region

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Structure of an extracellular gp130 cytokine receptor signaling complex

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A role for the immunoglobulin-like domain of the human IL-6 receptor. Intracellular protein transport and shedding

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Structure of the extracellular domains of the human interleukin-6 receptor alpha -chain

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Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6.

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The upper cytokine-binding module and the Ig-like domain of the leukaemia inhibitory factor (LIF) receptor are sufficient for a functional LIF receptor complex

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The soluble interleukin-6 receptor is generated by shedding

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Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation

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Receptor dimerization in GH and erythropoietin action--it takes two to tango, but how?

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Seeing the light: preassembly and ligand-induced changes of the interferon gamma receptor complex in cells

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An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation

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In vitro reconstitution of recognition and activation complexes between interleukin-6 and gp130.

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The family of the IL-6-type cytokines: specificity and promiscuity of the receptor complexes

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Erythropoietin receptor activation by a ligand-induced conformation change

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Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

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The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex

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IL-6 Receptor Independent Stimulation of Human gp130 by Viral IL-6

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Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130

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A structural template for gp130-cytokine signaling assemblies.

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Novel pathogenic mechanism of microbial metalloproteinases: liberation of membrane-anchored molecules in biologically active form exemplified by studies with the human interleukin-6 receptor

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