The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex (Q34991808)

5 August 2017

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title

The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex (English)

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5 August 2017

Simon A Jones

1

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Stefan Rose-John

object named as

Stefan Rose-John

series ordinal

2

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language of work or name

English

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publication date

1 November 2002

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Biochimica et Biophysica Acta

5 August 2017

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5 August 2017

1592

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5 August 2017

251-263

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5 August 2017

3

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Soluble receptors for cytokines and growth factors: generation and biological function

5 August 2017

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Membrane protein secretases

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Metalloprotease-disintegrins: links to cell adhesion and cleavage of TNF alpha and Notch

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Soluble cytokine receptors are present in normal human urine

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The soluble interleukin 6 receptor: mechanisms of production and implications in disease

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Role of Metalloproteases in the Release of the IL-1 type II Decoy Receptor

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Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist

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The tumor necrosis factor ligand and receptor families.

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Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF.

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Gp130 and the interleukin-6 family of cytokines

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CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex

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Signaling mechanisms through cytokine receptors that share signal transducing receptor components

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The soluble interleukin-6 receptor is generated by shedding

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Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

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The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6.

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gp130 and c-Kit signalings synergize for ex vivo expansion of human primitive hemopoietic progenitor cells

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Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6

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Neural activities of IL-6-type cytokines often depend on soluble cytokine receptors

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Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism

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Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor

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Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor.

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High-level production of alternatively spliced soluble interleukin-6 receptor in serum of patients with adult T-cell leukaemia/HTLV-I-associated myelopathy

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Purification and characterization of the soluble interleukin-6 receptor from human plasma and identification of an isoform generated through alternative splicing

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IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation

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C-reactive protein: a physiological activator of interleukin 6 receptor shedding.

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Retrograde inflammatory signaling from neutrophils to endothelial cells by soluble interleukin-6 receptor alpha

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The IL-6-soluble IL-6Ralpha autocrine loop of endothelial activation as an intermediate between acute and chronic inflammation: an experimental model involving thrombin

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Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

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Released form of CNTF receptor alpha component as a soluble mediator of CNTF responses

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Cardiotrophin-1, a cytokine present in embryonic muscle, supports long-term survival of spinal motoneurons.

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The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine

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Extramedullary expansion of hematopoietic progenitor cells in interleukin (IL)-6-sIL-6R double transgenic mice

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Analysis of interleukin 6 receptor and gp130 expressions and proliferative capability of human CD34+ cells

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Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells

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gp130-stimulating designer cytokine Hyper-interleukin-6 synergizes with murine stroma for long-term survival of primitive human hematopoietic progenitor cells.

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Optimization of retroviral-mediated gene transfer to human NOD/SCID mouse repopulating cord blood cells through a systematic analysis of protocol variables.

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Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver.

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Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration

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Liver regeneration induced by a designer human IL-6/sIL-6R fusion protein reverses severe hepatocellular injury.

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Hyper-IL-6 gene therapy reverses fulminant hepatic failure.

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A possible role for soluble IL-6 receptor in the pathogenesis of systemic onset juvenile chronic arthritis

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Serum levels of interleukin-6 type cytokines and soluble interleukin-6 receptor in patients with rheumatoid arthritis

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Interleukin-6 and its soluble receptor cause a marked induction of collagenase 3 expression in rat osteoblast cultures

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Effects of IL-6 and its soluble receptor on proteoglycan synthesis and NO release by human articular chondrocytes: comparison with IL-1. Modulation by dexamethasone

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IL-6 and its soluble receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage

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Immunoadhesins of interleukin-6 and the IL-6/soluble IL-6R fusion protein hyper-IL-6

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Human herpesvirus 8 encodes a homolog of interleukin-6.

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Human herpes virus 8 interleukin-6 homologue triggers gp130 on neuronal and hematopoietic cells

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IL-6 Receptor Independent Stimulation of Human gp130 by Viral IL-6

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Structure of an extracellular gp130 cytokine receptor signaling complex

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Differential shedding of the two subunits of the interleukin-6 receptor

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Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis

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Identification and Characterization of Two Distinct Truncated Forms of gp130 and a Soluble Form of Leukemia Inhibitory Factor Receptor α-Chain in Normal Human Urine and Plasma

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Identifiers

DOI

1 reference

5 August 2017

1 reference

PubMed ID

12421670