Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism (Q24297873)

GOA release 2020-03-11

amyloid-beta binding

1 reference

Journal of Biological Chemistry

GOA release 2020-03-11

author name string

Hidenori Taru

series ordinal

1

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Yutaka Kirino

series ordinal

2

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Toshiharu Suzuki

series ordinal

3

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language of work or name

English

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publication date

26 July 2002

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published in

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volume

277

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issue

30

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page(s)

27567-74

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1 reference

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Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

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Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

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Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

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The presenilins in Alzheimer's disease--proteolysis holds the key.

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Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing

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Beta-amyloid precursor protein cleavage by a membrane-bound protease

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Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

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Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein.

21 January 2018

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A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

1 reference

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A basic amino acid in the cytoplasmic domain of Alzheimer's beta-amyloid precursor protein (APP) is essential for cleavage of APP at the alpha-site.

21 January 2018

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Phosphorylation-induced structural changes in the amyloid precursor protein cytoplasmic tail detected by NMR.

21 January 2018

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Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid

21 January 2018

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Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein

21 January 2018

1 reference

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The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion

21 January 2018

1 reference

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X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion

21 January 2018

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Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein

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Interaction of Alzheimer's beta -amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade

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A cytoplasmic inhibitor of the JNK signal transduction pathway

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A mammalian scaffold complex that selectively mediates MAP kinase activation

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The JIP group of mitogen-activated protein kinase scaffold proteins

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21 January 2018

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Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules

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The function of PTB domain proteins

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The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein

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Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons

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Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein

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Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide

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Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein

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Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport

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Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

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Dynamic regulation of c-Jun N-terminal kinase activity in mouse brain by environmental stimuli

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Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3).

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JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway

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Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3

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Molecular cloning of multiple splicing variants of JIP-1 preferentially expressed in brain

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Identification of Residues within the SHC Phosphotyrosine Binding/Phosphotyrosine Interaction Domain Crucial for Phosphopeptide Interaction

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Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway. Identification of intracellular compartments in which APP cleavage occurs without using toxic agents that int

21 January 2018

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Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42

21 January 2018

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The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells.

21 January 2018

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Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

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Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein.

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Regulation of amyloid precursor protein catabolism involves the mitogen-activated protein kinase signal transduction pathway.

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Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation.

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Dual roles for c-Jun N-terminal kinase in developmental and stress responses in cerebellar granule neurons.

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Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase.

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7 January 2021