Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase. (Q40794695)

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English	Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase.	scientific article

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9 November 2019

Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase (English)

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9 November 2019

Simon Lovestone

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A Mudher

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S Chapman

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J Richardson

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A Asuni

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G Gibb

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C Pollard

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R Killick

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T Iqbal

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L Raymond

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I Varndell

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P Sheppard

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A Makoff

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E Gower

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P E Soden

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P Lewis

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M Murphy

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T E Golde

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H T Rupniak

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B H Anderton

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1 July 2001

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9 November 2019

Journal of Neuroscience

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9 November 2019

4987-4995

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9 November 2019

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9 November 2019

Regulation by phorbol esters of amyloid precursor protein release from Swiss 3T3 fibroblasts overexpressing protein kinase C alpha.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of protein kinase C inhibits cellular production of the amyloid beta-protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the Wnt signaling pathway: a molecular mechanism for lithium action.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lithium protects cultured neurons against beta-amyloid-induced neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A molecular mechanism for the effect of lithium on development

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WNT-1 and HGF regulate GSK3 beta activity and beta-catenin signaling in mammary epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of beta-amyloid production by activation of protein kinase C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retroviral expression of Wnt-1 and Wnt-7b produces different effects in mouse mammary epithelium.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: the amyloid cascade hypothesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of RhoA in tissue polarity and Frizzled signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A cytoplasmic inhibitor of the JNK signal transduction pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilins, processing of beta-amyloid precursor protein, and notch signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Angiotensin-converting enzyme and the amyloid precursor protein secretases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dishevelled-1 regulates microtubule stability: a new function mediated by glycogen synthase kinase-3beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of the mouse dishevelled-1 protein inhibits GSK-3beta-mediated phosphorylation of tau in transfected mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid precursor protein secretion and beta A4 amyloid generation are not mutually exclusive

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Does dysregulation of the Notch and wingless/Wnt pathways underlie the pathogenesis of Alzheimer's disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction between Wingless and Notch signaling pathways mediated by dishevelled.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that the beta-catenin nuclear translocation assay allows for measuring presenilin 1 dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein kinase-dependent and protein kinase C-dependent pathways link the m1 muscarinic receptor to beta-amyloid precursor protein secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid precursor protein (APP) and the angiotensin converting enzyme (ACE) secretase are inhibited by hydroxamic acid-based inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

wingless acts through the shaggy/zeste-white 3 kinase to direct dorsal-ventral axis formation in the Drosophila leg.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro phosphorylation of the cytoplasmic domain of the amyloid precursor protein by glycogen synthase kinase-3beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of tau by glycogen synthase kinase-3β in intact mammalian cells: The effects on the organization and stability of microtubules

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of beta-catenin signaling in the Wnt pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C activation increases release of secreted amyloid precursor protein without decreasing Abeta production in human primary neuron cultures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The dishevelled protein is modified by wingless signaling in Drosophila

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of increased glycogen synthase kinase-3 activity upon the maturation of the amyloid precursor protein in transfected cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of amyloid precursor protein cleavage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity of alpha-secretase as the common final effector of protein kinase C-dependent and -independent modulation of amyloid precursor protein metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt-mediated relocalization of dishevelled proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3).

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signalling downstream of activated mammalian Notch

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.21-14-04987.2001

1 reference

Europe PubMed Central

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9 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11438574%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11438574%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

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