Degradation of the LDL receptors by PCSK9 is not mediated by a secreted protein acted upon by PCSK9 extracellularly (Q24298534)

GOA release 2020-03-11

author name string

Øystein L Holla

1

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Jamie Cameron

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Knut Erik Berge

3

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Trine Ranheim

4

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Trond P Leren

https://scigraph.springernature.com/pub.10.1186/1471-2121-8-9

5

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language of work or name

English

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publication date

2007

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published in

BMC Cell Biology

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volume

8

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page(s)

9

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issue

1

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exact match

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cites work

Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice

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The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications

19 March 2017

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Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype

19 March 2017

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Functional characterization of Narc 1, a novel proteinase related to proteinase K

19 March 2017

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Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

19 March 2017

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The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

19 March 2017

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Expression and localization of PCSK9 in rat hepatic cells

19 March 2017

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Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells

19 March 2017

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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

19 March 2017

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Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote

19 March 2017

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Effect of mutations in the PCSK9 gene on the cell surface LDL receptors

27 September 2017

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Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes

27 September 2017

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A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol.

27 September 2017

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Novel mutations of the PCSK9 gene cause variable phenotype of autosomal dominant hypercholesterolemia

27 September 2017

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Additive effect of mutations in LDLR and PCSK9 genes on the phenotype of familial hypercholesterolemia

27 September 2017

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Evidence for effect of mutant PCSK9 on apolipoprotein B secretion as the cause of unusually severe dominant hypercholesterolaemia

27 September 2017

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Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment

27 September 2017

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Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

27 September 2017

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Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver.

27 September 2017

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NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

27 September 2017

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Apolipoprotein B100 metabolism in autosomal-dominant hypercholesterolemia related to mutations in PCSK9.

27 September 2017

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Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia

27 September 2017

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A mutation in PCSK9 causing autosomal-dominant hypercholesterolemia in a Utah pedigree

27 September 2017

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Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice

27 September 2017

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Molecules internalized by clathrin-independent endocytosis are delivered to endosomes containing transferrin receptors

27 September 2017

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Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation

30 May 2018

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Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy.

30 May 2018

1 reference

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Retention of mutant low density lipoprotein receptor in endoplasmic reticulum (ER) leads to ER stress.

29 November 2018

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Effect of osmolarity on LDL binding and internalization in hepatocytes

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17328821

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1471-2121-8-9

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Dimensions Publication ID

913427

1020669391

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913427

1 reference

1 reference

1 reference