Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver. (Q38336252)

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English	Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver.	scientific article

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2 January 2020

Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver (English)

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2 January 2020

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Sahng Wook Park

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Jay D Horton

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Young-Ah Moon

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22 September 2004

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9

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Journal of Biological Chemistry

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50630-50638

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2 January 2020

The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis

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The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

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Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

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The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

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Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a

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Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane

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Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins

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Domain map of the LDL receptor: Sequence homology with the epidermal growth factor precursor

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Normal Sorting but Defective Endocytosis of the Low Density Lipoprotein Receptor in Mice with Autosomal Recessive Hypercholesterolemia

1 reference

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SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

1 reference

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Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene

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Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade

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Isolation of cholesterol-requiring mutant Chinese hamster ovary cells with defects in cleavage of sterol regulatory element-binding proteins at site 1.

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Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein.

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Transport-Dependent Proteolysis of SREBP

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Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c

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Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery

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Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene

1 reference

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21 January 2018

Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis

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Receptor-mediated endocytosis: concepts emerging from the LDL receptor system

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Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein

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Characterization of a novel cellular defect in patients with phenotypic homozygous familial hypercholesterolemia

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ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2

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The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits

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10.1074/JBC.M410077200

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2 January 2020

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