Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer (Q24298712)

guanyl-nucleotide exchange factor activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Bernardo Ochoa-Montaño

4

0 references

Tom Blundell

10

object named as

Tom L Blundell

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Dimitri Y Chirgadze

7

object named as

Dimitri Y Chirgadze

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author name string

Ravi K Nookala

1

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Lars Langemeyer

2

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Angela Pacitto

3

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Jane C Donaldson

5

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Beata K Blaszczyk

6

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Francis A Barr

8

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J Fernando Bazan

A kinesin-1 binding motif in vaccinia virus that is widespread throughout the human genome

9

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language of work or name

English

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publication date

August 2012

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published in

Open Biology

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volume

2

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issue

8

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page(s)

120071

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cites work

1 reference

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19 March 2017

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Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signaling

19 March 2017

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Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein

19 March 2017

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Progress and challenges in protein structure prediction

19 March 2017

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Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling

19 March 2017

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Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate

19 March 2017

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Dali server: conservation mapping in 3D

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Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2

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Renal tumour suppressor function of the Birt-Hogg-Dubé syndrome gene product folliculin

19 March 2017

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Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia

19 March 2017

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Avl9p, a member of a novel protein superfamily, functions in the late secretory pathway

19 March 2017

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Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators

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Protein homology detection by HMM-HMM comparison

19 March 2017

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Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome

19 March 2017

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Rab proteins as membrane organizers

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19 March 2017

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The human DENN gene: genomic organization, alternative splicing, and localization to chromosome 11p11.21-p11.22

19 March 2017

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Classification and evolution of P-loop GTPases and related ATPases

19 March 2017

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7 April 2017

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Rab5 proteins regulate activation and localization of target of rapamycin complex 1.

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Connecdenn 3/DENND1C binds actin linking Rab35 activation to the actin cytoskeleton

27 September 2017

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Thousands of rab GTPases for the cell biologist

27 September 2017

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Absence of the Birt-Hogg-Dubé gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibility

27 September 2017

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Signaling pathways in renal cell carcinoma

27 September 2017

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EAU guidelines on renal cell carcinoma: the 2010 update

27 September 2017

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The genetic basis of kidney cancer: a metabolic disease

27 September 2017

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27 September 2017

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Germline BHD-mutation spectrum and phenotype analysis of a large cohort of families with Birt-Hogg-Dubé syndrome

27 September 2017

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Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8

27 September 2017

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Definition of general topological equivalence in protein structures. A procedure involving comparison of properties and relationships through simulated annealing and dynamic programming

27 September 2017

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Hereditary Multiple Fibrofolliculomas With Trichodiscomas and Acrochordons

27 September 2017

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The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe.

27 September 2017

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Crossref

https://api.crossref.org/works/10.1098%2FRSOB.120071

An ARF6/Rab35 GTPase cascade for endocytic recycling and successful cytokinesis.

21 January 2018

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Crossref

https://api.crossref.org/works/10.1098%2FRSOB.120071

uDENN, DENN, and dDENN: indissociable domains in Rab and MAP kinases signaling pathways.

21 January 2018

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Crossref

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Inactivation of BHD in sporadic renal tumors.

21 January 2018

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29 November 2018

Identifiers

DOI

10.1098/RSOB.120071

1 reference

1 reference

1 reference

PubMed publication ID

22977732

1 reference