Promiscuous DNA synthesis by human DNA polymerase θ (Q24298854)

double-strand break repair

GOA release 2020-03-11

1 reference

Creative Commons Attribution-NonCommercial 3.0 Unported

GOA release 2020-03-11

Matthew Hogg

1

Matthew

Hogg

1 reference

19 October 2023

A Elisabeth Sauer-Eriksson

series ordinal

2

author given names

A Elisabeth

author last names

Sauer-Eriksson

1 reference

19 October 2023

Erik Johansson

series ordinal

3

author given names

Erik

author last names

Johansson

1 reference

19 October 2023

language of work or name

English

0 references

publication date

March 2012

0 references

published in

Nucleic Acids Research

0 references

volume

40

0 references

issue

6

0 references

page(s)

2611-22

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copyright license

start time

11 November 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageQuant

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3315306/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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1 reference

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Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315306

The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315306

High-efficiency bypass of DNA damage by human DNA polymerase Q

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315306

POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315306

End-bridging is required for pol mu to efficiently promote repair of noncomplementary ends by nonhomologous end joining

19 March 2017

1 reference

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Structural and biochemical investigation of the role in proofreading of a beta hairpin loop found in the exonuclease domain of a replicative DNA polymerase of the B family

19 March 2017

1 reference

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Absence of DNA polymerase theta results in decreased somatic hypermutation frequency and altered mutation patterns in Ig genes

19 March 2017

1 reference

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DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes

19 March 2017

1 reference

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A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining

19 March 2017

1 reference

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The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm

19 March 2017

1 reference

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Phenotype-based identification of mouse chromosome instability mutants

19 March 2017

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Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repair

19 March 2017

1 reference

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MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings

19 March 2017

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DNA polymerases and cancer.

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1 reference

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Lesion bypass activity of DNA polymerase θ (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts.

27 September 2017

1 reference

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Overexpression of POLQ confers a poor prognosis in early breast cancer patients

27 September 2017

1 reference

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Polymerases in nonhomologous end joining: building a bridge over broken chromosomes

27 September 2017

1 reference

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DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability

27 September 2017

1 reference

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Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila

27 September 2017

1 reference

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A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown

27 September 2017

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Lack of DNA polymerase theta (POLQ) radiosensitizes bone marrow stromal cells in vitro and increases reticulocyte micronuclei after total-body irradiation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315306

Low-fidelity DNA synthesis by human DNA polymerase theta.

27 September 2017

1 reference

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Reevaluation of the role of DNA polymerase theta in somatic hypermutation of immunoglobulin genes.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315306

Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315306

Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage

27 September 2017

1 reference

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A specific loop in human DNA polymerase mu allows switching between creative and DNA-instructed synthesis

27 September 2017

1 reference

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DNA polymerases and somatic hypermutation of immunoglobulin genes

27 September 2017

1 reference

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Crystallographic snapshots of a replicative DNA polymerase encountering an abasic site

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315306

DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancers

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315306

Polymerase mu is a DNA-directed DNA/RNA polymerase

27 September 2017

1 reference

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Most alpha/beta T cell receptor diversity is due to terminal deoxynucleotidyl transferase

27 September 2017

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Mice lacking terminal deoxynucleotidyl transferase: adult mice with a fetal antigen receptor repertoire

27 September 2017

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Novel non-templated nucleotide addition reactions catalyzed by procaryotic and eucaryotic DNA polymerases

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315306

The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I.

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315306

A comparative analysis of two conserved motifs in bacterial poly(A) polymerase and CCA-adding enzyme

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315306

Strand annealing and terminal transferase activities of a B-family DNA polymerase.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315306

A 'DNA replication' signature of progression and negative outcome in colorectal cancer

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315306

Caenorhabditis elegans POLQ-1 and HEL-308 function in two distinct DNA interstrand cross-link repair pathways.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315306

DNA polymerase theta (POLQ) can extend from mismatches and from bases opposite a (6-4) photoproduct

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315306

Role of DNA polymerase theta in tolerance of endogenous and exogenous DNA damage in mouse B cells

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315306

Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315306

Lesion bypass by human DNA polymerase mu reveals a template-dependent, sequence-independent nucleotidyl transferase activity.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315306

Terminal deoxynucleotidyl transferase indiscriminately incorporates ribonucleotides and deoxyribonucleotides

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315306

DNA polymerases eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22135286

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Deoxynucleotide-polymerizing enzymes of calf thymus gland. II. Properties of the terminal deoxynucleotidyltransferase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22135286

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NAR/GKR1102

1 reference

release_xsamh2ceq5bjpdoqfm4ft66kwy

685280

Fatcat ID

0 references

685280

1 reference

1 reference

1 reference