Activation and regulation of ATM kinase activity in response to DNA double-strand breaks (Q34722727)

4 August 2017

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title

Activation and regulation of ATM kinase activity in response to DNA double-strand breaks (English)

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4 August 2017

Lee JH

1

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4 August 2017

Paull TT

series ordinal

2

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4 August 2017

language of work or name

English

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publication date

1 December 2007

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4 August 2017

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4 August 2017

26

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4 August 2017

56

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4 August 2017

7741-7748

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1210872

4 August 2017

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cites work

Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Adenovirus type 5 E4orf3 protein targets the Mre11 complex to cytoplasmic aggresomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Detection of a tandem BRCT in Nbs1 and Xrs2 with functional implications in the DNA damage response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

FAT: a novel domain in PIK-related kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Chk2 activation dependence on Nbs1 after DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

The Mre11 complex is required for ATM activation and the G2/M checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Active role for nibrin in the kinetics of atm activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

ATR and ATRIP: partners in checkpoint signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Mre11 assembles linear DNA fragments into DNA damage signaling complexes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

DNA repair: The Nijmegen breakage syndrome protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

ATM-dependent phosphorylation of nibrin in response to radiation exposure

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

ATM-dependent dissociation of B55 regulatory subunit from nuclear PP2A in response to ionizing radiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Involvement of human MOF in ATM function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

ATMIN defines an NBS1-independent pathway of ATM signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Involvement of novel autophosphorylation sites in ATM activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Interaction between protein phosphatase 5 and the A subunit of protein phosphatase 2A: evidence for a heterotrimeric form of protein phosphatase 5

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

The rad50 signature motif: essential to ATP binding and biological function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Interaction of FANCD2 and NBS1 in the DNA damage response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

The Mre11 complex and ATM: collaborating to navigate S phase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

The p18 component of the multisynthetase complex shares a protein motif with the beta and gamma subunits of eukaryotic elongation factor 1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Genetic analysis of BRCA1 function in a defined tumor cell line

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

NFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

The ATM-mediated DNA-damage response: taking shape.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Activation of ataxia telangiectasia-mutated DNA damage checkpoint signal transduction elicited by herpes simplex virus infection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Residual ataxia telangiectasia mutated protein function in cells from ataxia telangiectasia patients, with 5762ins137 and 7271T-->G mutations, showing a less severe phenotype.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Requirement of the MRN complex for ATM activation by DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

53BP1, a mediator of the DNA damage checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

SV40 T antigen interacts with Nbs1 to disrupt DNA replication control.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Negative cell cycle regulation and DNA damage-inducible phosphorylation of the BRCT protein 53BP1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Functional analysis of FHA and BRCT domains of NBS1 in chromatin association and DNA damage responses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210872

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1210872

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Dimensions Publication ID

4 August 2017

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1 reference