Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells (Q24299207)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1990604

Endoplasmic reticulum to nucleus signaling 1

1 reference

TNF receptor associated factor 2

1 reference

mitogen-activated protein kinase kinase kinase 5

1 reference

Eukaryotic translation initiation factor 2 alpha kinase 3

1 reference

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

1 reference

1 reference

Qing-you Zheng

1

0 references

Ping-ping Li

2

0 references

Feng-suo Jin

3

0 references

Chen Yao

4

0 references

Guo-hui Zhang

5

0 references

Tong Zang

6

0 references

Xing Ai

Induction of apoptotic death by curcumin in human tongue squamous cell carcinoma SCC-4 cells is mediated through endoplasmic reticulum stress and mitochondria-dependent pathways

7

0 references

language of work or name

English

0 references

publication date

January 2013

0 references

published in

Cellular Signalling

0 references

volume

25

0 references

issue

1

0 references

page(s)

206-13

0 references

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2012.09.012

7 January 2021

Triterpenes augment the inhibitory effects of anticancer drugs on growth of human esophageal carcinoma cells in vitro and suppress experimental metastasis in vivo

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2012.09.012

7 January 2021

Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2012.09.012

7 January 2021

Ursolic acid-induced AMP-activated protein kinase (AMPK) activation contributes to growth inhibition and apoptosis in human bladder cancer T24 cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2012.09.012

7 January 2021

ER stress triggers apoptosis by activating BH3-only protein Bim

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2012.09.012

7 January 2021

Targeting the endoplasmic reticulum-stress response as an anticancer strategy

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2012.09.012

7 January 2021

ER-Golgi network--a future target for anti-cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2012.09.012

7 January 2021

Proliferative inhibition, cell-cycle dysregulation, and induction of apoptosis by ursolic acid in human non-small cell lung cancer A549 cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2012.09.012

7 January 2021

Signal transduction by the JNK group of MAP kinases

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2012.09.012

7 January 2021

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2012.09.012

7 January 2021

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2012.09.012

7 January 2021

The protein kinase PKR: a molecular clock that sequentially activates survival and death programs

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2012.09.012

7 January 2021

ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2012.09.012

7 January 2021

Ursolic acid-induced down-regulation of MMP-9 gene is mediated through the nuclear translocation of glucocorticoid receptor in HT1080 human fibrosarcoma cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2012.09.012

7 January 2021

Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2012.09.012

7 January 2021

Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2012.09.012

7 January 2021

Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2012.09.012

7 January 2021

Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2012.09.012

7 January 2021

CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2012.09.012

7 January 2021

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2012.09.012

7 January 2021

Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2012.09.012

7 January 2021

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2012.09.012

7 January 2021

Defects in translational regulation mediated by the alpha subunit of eukaryotic initiation factor 2 inhibit antiviral activity and facilitate the malignant transformation of human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2012.09.012

7 January 2021

Tetrocarcin-A--induced ER stress mediates apoptosis in B-CLL cells via a Bcl-2--independent pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2012.09.012

7 January 2021

Inhibition of proliferation by PERK regulates mammary acinar morphogenesis and tumor formation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2012.09.012

7 January 2021

Clinically useful anticancer, antitumor, and antiwrinkle agent, ursolic acid and related derivatives as medicinally important natural product

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2012.09.012

7 January 2021