Endoplasmic reticulum to nucleus signaling 1 (Q21115427)

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mammalian protein found in Homo sapiens
  • ERN1
  • protein kinase/endoribonuclease
  • ER to nucleus signalling 1
  • ire1-alpha
  • Endoplasmic reticulum-to-nucleus signaling 1
  • inositol-requiring protein 1
  • inositol-requiring 1
  • hIRE1p
  • IRE1a
  • inositol-requiring enzyme 1
  • serine/threonine-protein kinase/endoribonuclease IRE1
edit
Language Label Description Also known as
English
Endoplasmic reticulum to nucleus signaling 1
mammalian protein found in Homo sapiens
  • ERN1
  • protein kinase/endoribonuclease
  • ER to nucleus signalling 1
  • ire1-alpha
  • Endoplasmic reticulum-to-nucleus signaling 1
  • inositol-requiring protein 1
  • inositol-requiring 1
  • hIRE1p
  • IRE1a
  • inositol-requiring enzyme 1
  • serine/threonine-protein kinase/endoribonuclease IRE1

Statements

molecular function
protein binding
determination method
IPI
11 references
retrieved
1 January 2018
stated in
Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis
GOA
curator
UniProt
UniProt protein ID
O75460
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IPI
retrieved
1 January 2018
stated in
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IPI
retrieved
1 January 2018
stated in
USP14 inhibits ER-associated degradation via interaction with IRE1alpha
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IPI
retrieved
1 January 2018
stated in
JAB1 participates in unfolded protein responses by association and dissociation with IRE1
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IPI
retrieved
1 January 2018
stated in
A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IPI
retrieved
1 January 2018
stated in
Yip1A, a novel host factor for the activation of the IRE1 pathway of the unfolded protein response during Brucella infection
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IPI
retrieved
1 January 2018
stated in
Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IPI
retrieved
1 January 2018
stated in
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IPI
retrieved
1 January 2018
stated in
Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IPI
retrieved
1 January 2018
stated in
Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IPI
retrieved
1 January 2018
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IPI
endoribonuclease activity
determination method
IDA
TAS
IEA
7 references
retrieved
16 July 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
TAS
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
IEA
retrieved
16 July 2018
stated in
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
IDA
retrieved
16 July 2018
stated in
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
GOA
curator
UniProt
UniProt protein ID
O75460
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
IDA
retrieved
16 July 2018
stated in
Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
IDA
retrieved
16 July 2018
stated in
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
IDA
retrieved
16 July 2018
stated in
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
IDA
endoribonuclease activity
determination method
IBA
IDA
IEA
TAS
8 references
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
TAS
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
IEA
retrieved
1 January 2018
stated in
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
IDA
retrieved
1 January 2018
stated in
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
GOA
curator
UniProt
UniProt protein ID
O75460
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
IDA
retrieved
1 January 2018
stated in
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
IDA
retrieved
1 January 2018
stated in
Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
IDA
retrieved
1 January 2018
stated in
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
IBA
protein serine/threonine kinase activity
determination method
IBA
IDA
IEA
TAS
6 references
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
TAS
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
O75460
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
IEA
retrieved
1 January 2018
stated in
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
GOA
curator
UniProt
UniProt protein ID
O75460
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
IDA
retrieved
1 January 2018
stated in
Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
IBA
endoribonuclease activity
determination method
IBA
IDA
IEA
7 references
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IEA
retrieved
1 January 2018
stated in
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IDA
retrieved
1 January 2018
stated in
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
GOA
curator
UniProt
UniProt protein ID
O75460
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IDA
retrieved
1 January 2018
stated in
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IDA
retrieved
1 January 2018
stated in
Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IDA
retrieved
1 January 2018
stated in
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IBA
cell component
biological process
IRE1-mediated unfolded protein response
determination method
IDA
IEA
TAS
6 references
retrieved
16 July 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
TAS
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
IEA
retrieved
16 July 2018
stated in
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
IDA
retrieved
16 July 2018
stated in
A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response
GOA
curator
UniProt
UniProt protein ID
O75460
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
IDA
retrieved
16 July 2018
stated in
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
GOA
curator
UniProt
UniProt protein ID
O75460
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
IDA
retrieved
16 July 2018
stated in
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460
determination method
IDA
mRNA splicing, via endonucleolytic cleavage and ligation
determination method
IDA
IMP
TAS
7 references
retrieved
1 January 2018
stated in
The unfolded protein response: integrating stress signals through the stress sensor IRE1α
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
TAS
retrieved
1 January 2018
stated in
Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IMP
retrieved
1 January 2018
stated in
HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IMP
retrieved
1 January 2018
stated in
Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein response
GOA
curator
UniProt
UniProt protein ID
O75460
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IDA
retrieved
1 January 2018
stated in
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
GOA
curator
UniProt
UniProt protein ID
O75460
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IDA
retrieved
1 January 2018
stated in
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IDA
retrieved
1 January 2018
stated in
Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IDA
IRE1-mediated unfolded protein response
determination method
IBA
IDA
IEA
TAS
7 references
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
TAS
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IEA
retrieved
1 January 2018
stated in
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IDA
retrieved
1 January 2018
stated in
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
GOA
curator
UniProt
UniProt protein ID
O75460
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IDA
retrieved
1 January 2018
stated in
A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response
GOA
curator
UniProt
UniProt protein ID
O75460
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IDA
retrieved
1 January 2018
stated in
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460
determination method
IBA

Identifiers

 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21115427&oldid=2022962032"